The accuracy of the pitch angle deviation directly affects the guidance accuracy of the laser seeker. During the guidance process, the abnormal pitch angle deviation data will be produced when the seeker is affected by interference sources. In this paper, aiming to detect abnormal data in seeker pitch angle deviation data, a method based on Smooth Multi-Kernel Polarization Support Vector Data Description (SMP-SVDD) is proposed to detect abnormal data in guidance angle data. On the one hand, the polarization value is used to determine the weight of the multi-kernel combination coefficient to obtain the multi-kernel polarization function, and the particle swarm optimization is used to find the optimal kernel, which improves the detection accuracy. On the other hand, the constrained quadratic programming problem is smooth and differentiable, and the conjugate gradient method can be applied to reduce the complexity of problem solving. Through simulation experiments, it is verified that the SMP-SVDD method has higher detection accuracy and faster calculation speed compared with different detection methods in different guidance stages.