The present research is generally related to a system and method for predicting an infectious disease such as COVID-19 transmitted by a virulent respiratory virus. Disclosed are a system and method for predicting an infectious disease transmitted by a virulent respiratory virus. The system includes a plurality of Internet of Things (IoT) sensors, a plurality of fog node devices, and a plurality of computing devices in cloud data centers. The IoT sensors are configured to be coupled to a plurality of human beings to generate a health dataset. The fog node devices are associated with a fog layer to receive the health dataset from the IoT sensors to process and to store the health dataset over a blockchain network. The fog node devices process the health dataset at the fog layer by performing a fog computing. The computing devices and cloud data centers receive the processed health dataset from the of fog node devices over the blockchain network. This research is also filed for patent in Indian Patent Office with application number – 202011021969.