Based on the “State Register of Medicines, Medical Devices and Medical Equipment Permitted for Use in Medical Practice of the Republic of Uzbekistan” for 2016-2020 and the “DRUG AUDIT” program from 2016-2020, the numbers of domestically produced packages of antiemetic drugs in all dosage forms of antiemetic drugs of domestic production were counted, as were the numbers manufacturers of in the CIS countries and foreign manufacturers countries.
As can be seen from the data in Table 1, the share number of antiemetic drugs produced in the CIS countries accounteds for from 73,851 to 259,458 the number of imports at its peak in 2017 but, which by 2020 had decreased to 73,851, the. The share of Fforeign manufacturesmanufacturers of antiemetic drugs accounted for from 92,841 to 266,363 imports, which peaking in 2018 at was almost more than 2 times moretwice the number in each of the two previous years. The share number from of domestic producers, in contrast to the numbers the from CIS and foreign suppliers, was significantly increased from 144,372 to 876,989 (2017) (Fig. 1).
Table 1
Information on the total number of antiemetic drugs registered in the Republic of Uzbekistan for 2016-2020
№
|
Manufacturer / year
|
Domestic medicines
|
Medicines produced in CIS countries
|
Foreign medicines
|
Total number of packages, pcs
|
1
|
2016
|
144,372
|
163,450
|
94,388
|
402,210
|
2
|
2017
|
876,989
|
259,458
|
92,841
|
1,229,288
|
3
|
2018
|
758,141
|
180,910
|
266,363
|
1,205,414
|
4
|
2019
|
461,670
|
139,350
|
105,325
|
706,345
|
5
|
2020
|
361,548
|
73,851
|
163,886
|
599,285
|
During the study period, the volume of imports of antiemetic drugs from the CIS countries increased by 3.5 times, that from foreign countries by 2.9 times, and that from domestic manufacturers by 6 times.
The results show that antiemetic drugs in all dosage forms and registered and produced by domestic manufacturers for the five years account for an average of 62% of the total, with the remaining 38% (20% of the production of CIS countries and 18% of foreign countries) imported into the country for consumption for foreign currency accounts (Fig. 2).
Table 2 shows the numbers of antiemetic drugs in the form of tablets registered in the Republic of Uzbekistan for 2016-2020. Among the total imports of antiemetic drugs, the production of CIS countries began at 76211 and peaked at 202358 imports but by 2020 had decreased to 73851. The number from foreign manufacturers of antiemetic drugs ranges from 3300 to 35316 imports, with no imports in 2016. The number of domestically produced antiemetic drugs ranges from 24500 to 67689, but this drug was not domestically produced in the form of tablets over the last 3 years.
Table 2
Information on the number of antiemetic drugs in the form of tablets registered in the Republic of Uzbekistan for 2016-2020
№
|
Manufacturer / year
|
Domestic medicines
|
Medicines produced in CIS countries
|
Foreign medicines
|
Total number of packages, pcs
|
1
|
2016
|
24,500
|
76,211
|
0
|
100,711
|
2
|
2017
|
67,689
|
202,358
|
3,300
|
273,347
|
3
|
2018
|
0
|
179,830
|
24,710
|
204,540
|
4
|
2019
|
0
|
139,350
|
35,316
|
174,666
|
5
|
2020
|
0
|
73,851
|
34,380
|
108,231
|
The numbers of antiemetic drugs in the form of ampoules registered in the Republic of Uzbekistan for 2016-2020 are shown in Table 3. Within this category of antiemetic drugs, there were no imports from CIS countries and no production by domestic manufacturers, and foreign produced antiemetic drugs accounted for 12,065 to 25,740 imports, with no imports in 2017 or 2019.
Table 3
Information on the number of antiemetic drugs in the form of ampoules registered in the Republic of Uzbekistan for 2016-2020
№
|
Manufacturer / year
|
Domestic medicines
|
Medicines produced in CIS countries
|
Foreign medicines
|
Total number of packages, pcs
|
1
|
2016
|
0
|
0
|
25,740
|
25,740
|
2
|
2017
|
0
|
0
|
0
|
0
|
3
|
2018
|
0
|
0
|
18,570
|
18,570
|
4
|
2019
|
0
|
0
|
0
|
0
|
5
|
2020
|
0
|
0
|
12,065
|
12,065
|
Regarding the number of antiemetic drugs in the form of solutions registered in the Republic of Uzbekistan for 2016-2020, among the total imports of antiemetic drugs, the production of CIS countries ranged from 1,080 to 87,239, with no imports in 2019-2020, and the number of foreign produced antiemetic drugs ranged from 68,648 to 223,083 imports. The numbers produced by domestic manufacturers ranged from 119,872 to 809,300.
Table 4
Information on the number of antiemetic drugs in the form of solutions registered in the Republic of Uzbekistan for 2016-2020
№
|
Manufacturer / year
|
Domestic medicines
|
Medicines produced in CIS countries
|
Foreign medicines
|
Total number of packages, pcs
|
1
|
2016
|
119,872
|
87,239
|
68,648
|
275,759
|
2
|
2017
|
809,300
|
57,100
|
212,113
|
1,078,513
|
3
|
2018
|
758,141
|
1,080
|
223,083
|
982,304
|
4
|
2019
|
461,670
|
0
|
70,009
|
531,679
|
5
|
2020
|
361,548
|
0
|
106,710
|
468,258
|
Regarding the number of antiemetic drugs in the form of solution ampoules registered in the Republic of Uzbekistan for 2016-2020, information on the total imports of antiemetic drugs and the number produced by CIS countries and domestic manufacturers was not available; for foreign manufacturers, there were no imports from 2016 to 2019, while in 2020, 10,731 drugs were imported (Table 5).
Table 5
Information on the number of antiemetic drugs in the form of solution ampoules registered in the Republic of Uzbekistan for 2016-2020
№
|
Manufacturer / year
|
Domestic medicines
|
Medicines produced in CIS countries
|
Foreign medicines
|
Total number of packages, pcs
|
1
|
2016
|
0
|
0
|
0
|
0
|
2
|
2017
|
0
|
0
|
0
|
0
|
3
|
2018
|
0
|
0
|
0
|
0
|
4
|
2019
|
0
|
0
|
0
|
0
|
5
|
2020
|
0
|
0
|
10,731
|
10,731
|
|
|
The aim of this work was to study the domestic production of different dosage forms of antiemetic drugs registered in the Republic of Uzbekistan, depending on their manufacturers [11].
As seen from the data in Table 6, the analysis of domestically produced dosage forms of antiemetic drugs, based on information from the DRUG AUDIT program for 2016-2020, shows that 2,602,720 packages were produced by local manufacturers; of this total, a significant number were produced by Merrimed Farm, Uzbekistan (2,010,770 packages or 77%), all of them preparations in the form of solutions.
Table 6
The number of domestically produced medicinal products registered in the Republic of Uzbekistan for 2016 - 2020 by country and manufacturing firm
№
|
Company manufacturer
|
Dosage form / quantity, pcs
|
Total amount
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Merrimed Farm, Uzbekistan
|
0
|
0
|
2,040,770
|
0
|
2,010,770
|
2
|
Radiks, Uzbekistan
|
0
|
0
|
469,761
|
0
|
469,761
|
3
|
Gufik-Avitsenna, Uzbekistan
|
92,189
|
0
|
0
|
0
|
92,189
|
The total number of packages, pcs
|
92,189
|
0
|
2,510,531
|
0
|
2,602,720
|
Figure 3 shows the numbers of domestically produced antiemetic drugs produced in various dosage forms. As seen from Figure 3, a total of 2,602,720 packages were produced, of which 92,189 packages were in the form of tablets, 2,510,531 in the form of solutions, and none in the form of ampoules or ampoule solutions.
As seen from the data in Table 7, the analysis of dosage forms of antiemetic drugs produced in CIS countries, according to the DRUG AUDIT program for 2016-2020, shows that 2,602,720 packages were imported from manufacturers in CIS countries; a significant number of this total were produced by Borisovskiy, Belarus (659,609 packages or 97%), in the form of tablets and solutions.
Table 7
The number of medicines produced in CIS countries registered in the Republic of Uzbekistan for 2016 - 2020 by country and manufacturing firm
№
|
Company manufacturer
|
Dosage form / quantity, pcs
|
Total
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Yuria-Farm, Ukraine
|
0
|
0
|
1,260
|
0
|
1,260
|
2
|
Darnitsya, Ukraine
|
0
|
0
|
15,000
|
|
15,000
|
3
|
Borshagovskiy, Ukraine
|
0
|
0
|
1,800
|
0
|
1,800
|
4
|
Borisovskiy, Belarus
|
532,250
|
0
|
127,359
|
0
|
659,609
|
Total number of packages, pcs
|
532,250
|
0
|
145,419
|
0
|
677,669
|
Figure 4 shows the number of antiemetic drugs produced in CIS countries in various dosage forms. As seen from Figure 4, a total of 677,669 packages were produced, of which 532,250 packages were in the form of tablets and 145,419 in the form of solutions, while drugs in the form of ampoules and solution ampoules were not produced.
Table 8 The number of medicines produced in foreign countries registered in the Republic of Uzbekistan from 2016 to 2020 by country and manufacturing firm
№
|
Company manufacturer
|
Dosage form / quantity, pcs
|
Total
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Serena Healthcare, India
|
83,734
|
0
|
69,600
|
0
|
153,334
|
2
|
Cadila, India
|
13,972
|
0
|
41,659
|
0
|
55,631
|
3
|
Agio, India
|
0
|
56,375
|
0
|
0
|
56,375
|
4
|
Dr. Reddy's, India
|
0
|
0
|
190,008
|
0
|
190,008
|
5
|
Baxter Pharmaceuticals, India
|
0
|
0
|
40,256
|
0
|
40,256
|
6
|
Zieva Farm, India
|
0
|
0
|
25,000
|
0
|
25,000
|
7
|
Samarth Life Sciences, India
|
0
|
0
|
16,000
|
0
|
16,000
|
8
|
Mefar Ilac Sanayii, Turkey
|
0
|
0
|
1,000
|
0
|
1,000
|
9
|
Karan Healthcare, India
|
0
|
0
|
32,314
|
0
|
32,314
|
10
|
Claris, India
|
0
|
0
|
10,448
|
0
|
10,448
|
11
|
Elda International DMCC, India
|
0
|
0
|
2,179
|
0
|
2,179
|
12
|
Ultra Laboratories, India
|
0
|
0
|
31,931
|
0
|
31,931
|
13
|
LN Pharma, India
|
0
|
0
|
19,436
|
0
|
19,436
|
14
|
Mankind Pharma, India
|
0
|
0
|
28,000
|
0
|
28,000
|
15
|
Hebei Tiancheng Pharm, China
|
0
|
0
|
30,480
|
0
|
30,480
|
16
|
Zhangjiakou Kaiwei Pharmaceutical, China
|
0
|
0
|
19,680
|
0
|
19,680
|
17
|
Demo, Greece
|
0
|
0
|
0
|
10,731
|
10,731
|
Total number of packages, pcs
|
97,706
|
56,375
|
557,991
|
10,731
|
722,803
|
Figure 5 shows the number of antiemetic drugs produced abroad in various dosage forms. A total of 722,803 packages were produced, of which 97,706 packages were in the form of tablets, 56,375 in the form of ampoules, 557,991 in the form of solutions, and 10,731 in the form of solution ampoules.
Regarding the prices of antiemetic drugs produced by domestic manufacturers in 2016-2020, the value for tablets amounted to 93,249 USD and for solutions to 1,478,945 USD, while ampoules and solution ampoules were not produced (Table 9) [2].
Table 9 Prices of domestically produced medicines registered in the Republic of Uzbekistan for 2016-2020
№
|
Company manufacturer
|
Dosage form / price ($)
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Merrimed Farm, Uzbekistan
|
0
|
0
|
1,124,274
|
0
|
2
|
Radiks, Uzbekistan
|
0
|
0
|
354,671
|
0
|
3
|
Gufik-Avitsenna, Uzbekistan
|
93,249
|
0
|
0
|
0
|
Total cost ($)
|
93,249
|
0
|
1,478,945
|
0
|
Regarding the prices of manufactured antiemetic drugs in CIS countries imported for 2016-2020, the value of drugs in the form of tablets was 342,704 USD and of solutions 259,977 USD, while ampoules and solution ampoules were not produced (Table 10) [2].
Table 10 Prices of medicines produced in CIS countries registered in the Republic of Uzbekistan for 2016-2020
№
|
Company manufacturer
|
Dosage form / price ($)
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Yuria-Farm, Ukraine
|
0
|
0
|
6,762
|
0
|
2
|
Darnitsya, Ukraine
|
0
|
0
|
27,900
|
|
3
|
Borshagovskiy, Ukraine
|
0
|
0
|
2,970
|
0
|
4
|
Borisovskiy, Belarus
|
342,704
|
0
|
222,345
|
0
|
Total cost ($)
|
342,704
|
0
|
259,977
|
0
|
Regarding the prices of antiemetic drugs manufactured in foreign countries for 2016-2020, the value of drugs in the form of tablets amounted to 265,996 USD, of ampoules to 507,187 USD, of solutions to 1,478,945 USD and of solution ampoules to 52,434 USD (Table 11) [2].
Table 11 Prices of medicines produced in foreign countries registered in the Republic of Uzbekistan for 2016-2020
№
|
Company manufacturer
|
Dosage form / price ($)
|
Tablets
|
Ampoules
|
Solutions
|
Solution ampoules
|
1
|
Serena Healthcare, India
|
189,438
|
0
|
174,000
|
0
|
2
|
Cadila, India
|
76,558
|
0
|
260,913
|
0
|
3
|
Agio, India
|
0
|
507,187
|
0
|
0
|
4
|
Dr. Reddy's, India
|
0
|
0
|
1,244,180
|
0
|
5
|
Baxter Pharmaceuticals, India
|
0
|
0
|
328,662
|
0
|
6
|
Zieva Farm, India
|
0
|
0
|
112,500
|
0
|
7
|
Samarth Life Sciences, India
|
0
|
0
|
85,980
|
0
|
8
|
Mefar Ilac Sanayii, Turkey
|
0
|
0
|
21,300
|
0
|
9
|
Karan Healthcare, India
|
0
|
0
|
412,496
|
0
|
10
|
Claris, India
|
0
|
0
|
583,639
|
0
|
11
|
Elda International DMCC, India
|
0
|
0
|
152,530
|
0
|
12
|
Ultra Laboratories, India
|
0
|
0
|
127,972
|
0
|
13
|
LN Pharma, India
|
0
|
0
|
118,124
|
0
|
14
|
Mankind Pharma, India
|
0
|
0
|
151,200
|
0
|
15
|
Hebei Tiancheng Pharm, China
|
0
|
0
|
27,432
|
0
|
16
|
Zhangjiakou Kaiwei Pharmaceutical, China
|
0
|
0
|
17,712
|
0
|
17
|
Demo, Greece
|
0
|
0
|
0
|
52,434
|
Total cost ($)
|
265,996
|
507,187
|
3,818,640
|
52,434
|
A comparison of the prices for 2016-2020 of medicines produced by domestic manufacturers and manufacturers in CIS and foreign countries registered in the Republic of Uzbekistan can be seen in Figure 7.