Acknowledgments
The authors thanks the members who helped to collect data in community study.
Authors’ contributions
YRL, YCJ, and THW conceived the project and wrote the manuscript. AMY, SLP, and SLC processed and analyzed the data. YRL, SLP, and HHC collected data. WYL, WCH, YCC, HHC, and HHL contributed to the data interpretation. All authors read and approved the final manuscript.
Funding Sources
Study Funding: This study was supported by China Medical University Hospital, Taiwan (CMU No. DMR-103-051) and the Ministry of Science and Technology (MOST 107-3017-F-002-003) and Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (grant number NTU-107L9003).
Availability of data and materials
The data generated during this study are included in this article. All raw data used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
This study was approved by National Taiwan University Hospital (NTUH) Research Ethics Committee
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
Authors’ information
Department of Neurology, China Medical University Hospital, No. 360, Neihu Road, Sec 2, Taipei, 114, Taiwan
Yun-Ru Lu
Department of Family Medicine, Taipei Medical University Hospital, No. 250 Wu-Hsing Street, Taipei,100, Taiwan
Ya-Chung Jeng,
Department of Neurology, China Medical University Hospital , No. 2, Yude Road, Taichung, 40447, Taiwan
Wen-Yuan Lee
Department of Neurology, Shin-Kong WHS Memorial Hospital, No. 95 Wen Chang Road, Taipei, 100, Taiwan
Wei-Chih Hsu
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei, 100, Taiwan
Amy Ming-Fang Yen, Sam Li-Sheng Chen
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, No. 1, Jen-Ai Road, Sec 1, Taipei, 100, Taiwan
Shin-Liang Pan
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17, Hsu Chow Road, Zhongzheng Dist., Taipei, 100, Taiwan
Yen-Ching Chen, Hsiu-Hsi Chen
Department of Neurology, National Taiwan University Hospital, No. 1, Jen-Ai Road, Sec 1, Taipei, 100, Taiwan
Horng-Huei Liou
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, No. 1, Jen-Ai Road, Sec 1, Taipei, 100, Taiwan
Tzy-Haw Wu, MD