1. Becker JC. Merkel cell carcinoma. Ann Oncol. 2010;21 Suppl 7:vii81-85.https://doi.org/10.1093/annonc/mdq366
2. Garrett GL, Blanc PD, Boscardin J, et al. Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States. JAMA Dermatol.2017;153(3):296-303.https://doi.org/10.1001/jamadermatol.2016.4920
3. Agelli M, Clegg LX. Epidemiology of primary Merkel cell carcinoma in the United States. Journal of the American Academy of Dermatology.2003;49(5):832-841.https://doi.org/10.1016/s0190-9622(03)02108-x
4. Tadmor T, Liphshitz I, Aviv A, Landgren O, Barchana M, Polliack A. Increased incidence of chronic lymphocytic leukaemia and lymphomas in patients with Merkel cell carcinoma - a population based study of 335 cases with neuroendocrine skin tumour. Br J Haematol.2012;157(4):457-462.https://doi.org/10.1111/j.1365-2141.2012.09087.x
5. DeCaprio JA. Merkel cell polyomavirus and Merkel cell carcinoma. Philos Trans R Soc Lond B Biol Sci.2017;372(1732).https://doi.org/10.1098/rstb.2016.0276
6. Álvarez-Argüelles ME, Melón S, Rojo S, et al. Detection and quantification of Merkel cell polyomavirus. Analysis of Merkel cell carcinoma cases from 1977 to 2015. J Med Virol.2017;89(12):2224-2229.https://doi.org/10.1002/jmv.24896
7. Wang L, Harms PW, Palanisamy N, et al. Age and Gender Associations of Virus Positivity in Merkel Cell Carcinoma Characterized Using a Novel RNA In Situ Hybridization Assay. Clin Cancer Res.2017;23(18):5622-5630.https://doi.org/10.1158/1078-0432.Ccr-17-0299
8. Toker C. Trabecular carcinoma of the skin. Arch Dermatol.1972;105(1):107-110.https://doi.org/10.1001/archderm.1972.01620040075020
9. Youlden DR, Soyer HP, Youl PH, Fritschi L, Baade PD. Incidence and survival for Merkel cell carcinoma in Queensland, Australia, 1993-2010. JAMA Dermatol.2014;150(8):864-872.https://doi.org/10.1001/jamadermatol.2014.124
10. Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L. Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival. Br J Dermatol.2011;165(5):1051-1057.https://doi.org/10.1111/j.1365-2133.2011.10493.x
11. Jacobs D, Huang H, Olino K, et al. Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States. JAMA Dermatol.2021;157(1):59-65.https://doi.org/10.1001/jamadermatol.2020.4102
12. Zaar O, Gillstedt M, Lindelöf B, Wennberg-Larkö AM, Paoli J. Merkel cell carcinoma incidence is increasing in Sweden. J Eur Acad Dermatol Venereol.2016;30(10):1708-1713.https://doi.org/10.1111/jdv.13698
13. Scott MP, Helm KF. Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol.1999;21(1):16-20.https://doi.org/10.1097/00000372-199902000-00003
14. Paulson KG, Park SY, Vandeven NA, et al. Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics. J Am Acad Dermatol.2018;78(3):457-463.e452.https://doi.org/10.1016/j.jaad.2017.10.028
15. Fitzgerald TL, Dennis S, Kachare SD, Vohra NA, Wong JH, Zervos EE. Dramatic Increase in the Incidence and Mortality from Merkel Cell Carcinoma in the United States. Am Surg.2015;81(8):802-806.https://doi.org/10.1177/000313481508100819
16. Houben R, Schrama D, Becker JC. Molecular pathogenesis of Merkel cell carcinoma. Exp Dermatol.2009;18(3):193-198.https://doi.org/10.1111/j.1600-0625.2009.00853.x
17. Grotz TE, Tarantola TI, Otley CC, Weaver AL, McGree ME, Jakub JW. Natural history of merkel cell carcinoma following locoregional recurrence. Ann Surg Oncol.2012;19(8):2556-2562.https://doi.org/10.1245/s10434-011-2161-x
18. Harms KL, Healy MA, Nghiem P, et al. Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System. Ann Surg Oncol.2016;23(11):3564-3571.https://doi.org/10.1245/s10434-016-5266-4
19. Bichakjian CK, Olencki T, Aasi SZ, et al. Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw.2018;16(6):742-774.https://doi.org/10.6004/jnccn.2018.0055
20. Fields RC, Busam KJ, Chou JF, et al. Recurrence and survival in patients undergoing sentinel lymph node biopsy for merkel cell carcinoma: analysis of 153 patients from a single institution. Ann Surg Oncol.2011;18(9):2529-2537.https://doi.org/10.1245/s10434-011-1662-y
21. Hitchcock CL, Bland KI, Laney RG, 3rd, Franzini D, Harris B, Copeland EM, 3rd. Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment. Ann Surg.1988;207(2):201-207.https://doi.org/10.1097/00000658-198802000-00015
22. Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol.2001;8(3):204-208.https://doi.org/10.1007/s10434-001-0204-4
23. Santamaria-Barria JA, Boland GM, Yeap BY, Nardi V, Dias-Santagata D, Cusack JC, Jr. Merkel cell carcinoma: 30-year experience from a single institution. Ann Surg Oncol.2013;20(4):1365-1373.https://doi.org/10.1245/s10434-012-2779-3
24. Chen S, Liu Y, Yang J, et al. Development and Validation of a Nomogram for Predicting Survival in Male Patients With Breast Cancer. Front Oncol.2019;9:361.https://doi.org/10.3389/fonc.2019.00361
25. Wang Y, Li J, Xia Y, et al. Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol.2013;31(9):1188-1195.https://doi.org/10.1200/jco.2012.41.5984
26. Wang X, Mao M, He Z, et al. Development and Validation of a Prognostic Nomogram in AFP-negative hepatocellular carcinoma. Int J Biol Sci.2019;15(1):221-228.https://doi.org/10.7150/ijbs.28720
27. Wang S, Yang L, Ci B, et al. Development and Validation of a Nomogram Prognostic Model for SCLC Patients. J Thorac Oncol.2018;13(9):1338-1348.https://doi.org/10.1016/j.jtho.2018.05.037
28. Tang X, Zhou X, Li Y, et al. A Novel Nomogram and Risk Classification System Predicting the Cancer-Specific Survival of Patients with Initially Diagnosed Metastatic Esophageal Cancer: A SEER-Based Study. Ann Surg Oncol.2019;26(2):321-328.https://doi.org/10.1245/s10434-018-6929-0
29. Bhatia S, Storer BE, Iyer JG, et al. Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base. J Natl Cancer Inst.2016;108(9).https://doi.org/10.1093/jnci/djw042
30. Conic RRZ, Ko J, Saridakis S, et al. Sentinel lymph node biopsy in Merkel cell carcinoma: Predictors of sentinel lymph node positivity and association with overall survival. J Am Acad Dermatol.2019;81(2):364-372.https://doi.org/10.1016/j.jaad.2019.03.027
31. Tam M, Luu M, Barker CA, et al. Improved survival in women versus men with merkel cell carcinoma. J Am Acad Dermatol.2021;84(2):321-329.https://doi.org/10.1016/j.jaad.2020.02.034
32. Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol.2016;16(10):626-638.https://doi.org/10.1038/nri.2016.90
33. Wang S, Cowley LA, Liu XS. Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy. Molecules.2019;24(18).https://doi.org/10.3390/molecules24183214
34. Sridharan V, Muralidhar V, Margalit DN, et al. Merkel Cell Carcinoma: A Population Analysis on Survival. J Natl Compr Canc Netw.2016;14(10):1247-1257.https://doi.org/10.6004/jnccn.2016.0134
35. Iyer JG, Storer BE, Paulson KG, et al. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. J Am Acad Dermatol.2014;70(4):637-643.https://doi.org/10.1016/j.jaad.2013.11.031
36. Nguyen AT, Luu M, Lu DJ, et al. Quantitative metastatic lymph node burden and survival in Merkel cell carcinoma. J Am Acad Dermatol.2021;84(2):312-320.https://doi.org/10.1016/j.jaad.2019.12.072
37. Ghadjar P, Kaanders JH, Poortmans P, et al. The essential role of radiotherapy in the treatment of Merkel cell carcinoma: a study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys.2011;81(4):e583-591.https://doi.org/10.1016/j.ijrobp.2011.05.028
38. Leonard JH, Ramsay JR, Kearsley JH, Birrell GW. Radiation sensitivity of Merkel cell carcinoma cell lines. Int J Radiat Oncol Biol Phys.1995;32(5):1401-1407.https://doi.org/10.1016/0360-3016(94)00610-w
39. Pape E, Rezvoy N, Penel N, et al. Radiotherapy alone for Merkel cell carcinoma: a comparative and retrospective study of 25 patients. J Am Acad Dermatol.2011;65(5):983-990.https://doi.org/10.1016/j.jaad.2010.07.043
40. Veness M, Howle J. Radiotherapy alone in patients with Merkel cell carcinoma: the Westmead Hospital experience of 41 patients. Australas J Dermatol.2015;56(1):19-24.https://doi.org/10.1111/ajd.12263
41. Green MD, Hayman JA. Radiotherapy in the Multidisciplinary Management of Merkel Cell Carcinoma. J Natl Compr Canc Netw.2018;16(6):776-781.https://doi.org/10.6004/jnccn.2018.7045
42. Cowey CL, Mahnke L, Espirito J, Helwig C, Oksen D, Bharmal M. Real-world treatment outcomes in patients with metastatic Merkel cell carcinoma treated with chemotherapy in the USA. Future Oncol.2017;13(19):1699-1710.https://doi.org/10.2217/fon-2017-0187
43. Iyer JG, Blom A, Doumani R, et al. Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma. Cancer Med.2016;5(9):2294-2301.https://doi.org/10.1002/cam4.815
44. Voog E, Biron P, Martin JP, Blay JY. Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma. Cancer.1999;85(12):2589-2595.https://doi.org/10.1002/(sici)1097-0142(19990615)85:12<2589::aid-cncr15>3.0.co;2-f