Blau, O., Hofmann, W. K., Baldus, C. D., Thiel, G., Serbent, V., Schumann, E., . . . Blau, I. W. (2007). Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia. Exp Hematol, 35(2), 221-229. doi:10.1016/j.exphem.2006.10.012
Brown, C. W., Brodsky, A. S., & Freiman, R. N. (2015). Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res, 13(1), 78-85. doi:10.1158/1541-7786.MCR-14-0334
Carter, B. Z., Mak, P. Y., Wang, X., Tao, W., Ruvolo, V., Mak, D., . . . Andreeff, M. (2019). An ARC-Regulated IL1beta/Cox-2/PGE2/beta-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Cancer Res, 79(6), 1165-1177. doi:10.1158/0008-5472.CAN-18-0921
Carter, B. Z., Mak, P. Y., Wang, X., Yang, H., Garcia-Manero, G., Mak, D. H., . . . Andreeff, M. (2017). Focal Adhesion Kinase as a Potential Target in AML and MDS. Mol Cancer Ther, 16(6), 1133-1144. doi:10.1158/1535-7163.MCT-16-0719
Chaudhury, S. S., Morison, J. K., Gibson, B. E., & Keeshan, K. (2015). Insights into cell ontogeny, age, and acute myeloid leukemia. Exp Hematol, 43(9), 745-755. doi:10.1016/j.exphem.2015.05.008
Chen, S., Zambetti, N. A., Bindels, E. M., Kenswill, K., Mylona, A. M., Adisty, N. M., . . . Raaijmakers, M. H. (2016). Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs. Leukemia, 30(9), 1938-1942. doi:10.1038/leu.2016.91
Cheng, J., Li, Y., Liu, S., Jiang, Y., Ma, J., Wan, L., . . . Pang, T. (2019). CXCL8 derived from mesenchymal stromal cells supports survival and proliferation of acute myeloid leukemia cells through the PI3K/AKT pathway. FASEB J, 33(4), 4755-4764. doi:10.1096/fj.201801931R
Chin, C. H., Chen, S. H., Wu, H. H., Ho, C. W., Ko, M. T., & Lin, C. Y. (2014). cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol, 8 Suppl 4, S11. doi:10.1186/1752-0509-8-S4-S11
Cui, G., Cai, F., Ding, Z., & Gao, L. (2019). MMP14 predicts a poor prognosis in patients with colorectal cancer. Hum Pathol, 83, 36-42. doi:10.1016/j.humpath.2018.03.030
Darici, S., Alkhaldi, H., Horne, G., Jorgensen, H. G., Marmiroli, S., & Huang, X. (2020). Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence. J Clin Med, 9(9). doi:10.3390/jcm9092934
Dohner, H., Estey, E. H., Amadori, S., Appelbaum, F. R., Buchner, T., Burnett, A. K., . . . European, LeukemiaNet. (2010). Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood, 115(3), 453-474. doi:10.1182/blood-2009-07-235358
Geyh, S., Rodriguez-Paredes, M., Jager, P., Koch, A., Bormann, F., Gutekunst, J., . . . Schroeder, T. (2018). Transforming growth factor beta1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia. Haematologica, 103(9), 1462-1471. doi:10.3324/haematol.2017.186734
Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., . . . Frenette, P. S. (2014). Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell, 15(3), 365-375. doi:10.1016/j.stem.2014.06.020
Huang, J. C., Basu, S. K., Zhao, X., Chien, S., Fang, M., Oehler, V. G., . . . Becker, P. S. (2015). Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration. Blood Cancer J, 5, e302. doi:10.1038/bcj.2015.17
Jacamo, R., Chen, Y., Wang, Z., Ma, W., Zhang, M., Spaeth, E. L., . . . Andreeff, M. (2014). Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kappaB mediates chemoresistance. Blood, 123(17), 2691-2702. doi:10.1182/blood-2013-06-511527
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017). KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res, 45(D1), D353-D361. doi:10.1093/nar/gkw1092
Kessenbrock, K., Plaks, V., & Werb, Z. (2010). Matrix metalloproteinases: regulators of the tumor microenvironment. Cell, 141(1), 52-67. doi:10.1016/j.cell.2010.03.015
Konopleva, M., Konoplev, S., Hu, W., Zaritskey, A. Y., Afanasiev, B. V., & Andreeff, M. (2002). Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia, 16(9), 1713-1724. doi:10.1038/sj.leu.2402608
Lin, L. I., Lin, D. T., Chang, C. J., Lee, C. Y., Tang, J. L., & Tien, H. F. (2002). Marrow matrix metalloproteinases (MMPs) and tissue inhibitors of MMP in acute leukaemia: potential role of MMP-9 as a surrogate marker to monitor leukaemic status in patients with acute myelogenous leukaemia. Br J Haematol, 117(4), 835-841. doi:10.1046/j.1365-2141.2002.03510.x
Liu, X., Ma, Y., Li, R., Guo, D., Wang, N., Zhao, Y., . . . Ma, X. (2018). Niche TWIST1 is critical for maintaining normal hematopoiesis and impeding leukemia progression. Haematologica, 103(12), 1969-1979. doi:10.3324/haematol.2018.190652
Liu, Y., Zhang, J., Chen, Y., Sohel, H., Ke, X., Chen, J., & Li, Y. X. (2020). The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis. Aging (Albany NY), 12(1), 204-223. doi:10.18632/aging.102610
Love, M. I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol, 15(12), 550. doi:10.1186/s13059-014-0550-8
Mao, M., Alavi, M. V., Labelle-Dumais, C., & Gould, D. B. (2015). Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms. Curr Top Membr, 76, 61-116. doi:10.1016/bs.ctm.2015.09.002
Nepstad, I., Hatfield, K. J., Gronningsaeter, I. S., & Reikvam, H. (2020). The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells. Int J Mol Sci, 21(8). doi:10.3390/ijms21082907
Ries, C., Loher, F., Zang, C., Ismair, M. G., & Petrides, P. E. (1999). Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. Clin Cancer Res, 5(5), 1115-1124.
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., . . . Ideker, T. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res, 13(11), 2498-2504. doi:10.1101/gr.1239303
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., . . . Dick, J. E. (2014). Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature, 506(7488), 328-333. doi:10.1038/nature13038
Sorokina, T., Shipounova, I., Bigildeev, A., Petinati, N., Drize, N., Turkina, A., . . . Savchenko, V. (2016). The ability of multipotent mesenchymal stromal cells from the bone marrow of patients with leukemia to maintain normal hematopoietic progenitor cells. Eur J Haematol, 97(3), 245-252. doi:10.1111/ejh.12713
Stawowczyk, M., Wellenstein, M. D., Lee, S. B., Yomtoubian, S., Durrans, A., Choi, H., . . . Mittal, V. (2017). Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia, 19(2), 55-64. doi:10.1016/j.neo.2016.11.005
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., . . . von Mering, C. (2015). STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res, 43(Database issue), D447-452. doi:10.1093/nar/gku1003
Vaniotis, G., Rayes, R. F., Qi, S., Milette, S., Wang, N., Perrino, S., . . . Brodt, P. (2018). Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis. Oncogene, 37(28), 3790-3805. doi:10.1038/s41388-018-0242-z
Vardiman, J. W., Thiele, J., Arber, D. A., Brunning, R. D., Borowitz, M. J., Porwit, A., . . . Bloomfield, C. D. (2009). The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood, 114(5), 937-951. doi:10.1182/blood-2009-03-209262
Vedi, A., Santoro, A., Dunant, C. F., Dick, J. E., & Laurenti, E. (2016). Molecular landscapes of human hematopoietic stem cells in health and leukemia. Ann N Y Acad Sci, 1370(1), 5-14. doi:10.1111/nyas.12981
Walter, R. B., Othus, M., Burnett, A. K., Lowenberg, B., Kantarjian, H. M., Ossenkoppele, G. J., . . . Estey, E. H. (2013). Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients. Blood, 121(13), 2424-2431. doi:10.1182/blood-2012-10-462440
Wang, C., Chen, Z., Li, Z., & Cen, J. (2010). The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. Leuk Res, 34(8), 1083-1090. doi:10.1016/j.leukres.2010.01.016
Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., . . . Carlesso, N. (2014). Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kappaB-dependent manner. Cell Stem Cell, 15(1), 51-65. doi:10.1016/j.stem.2014.04.021
Winkler, I. G., Barbier, V., Nowlan, B., Jacobsen, R. N., Forristal, C. E., Patton, J. T., . . . Levesque, J. P. (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med, 18(11), 1651-1657. doi:10.1038/nm.2969
Yan, T., Lin, Z., Jiang, J., Lu, S., Chen, M., Que, H., . . . Zheng, Q. (2015). MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. Am J Transl Res, 7(5), 950-958.
Yehudai-Resheff, S., Attias-Turgeman, S., Sabbah, R., Gabay, T., Musallam, R., Fridman-Dror, A., & Zuckerman, T. (2019). Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells. Int J Cancer, 144(9), 2279-2289. doi:10.1002/ijc.32063
Yu, G., Wang, L. G., Han, Y., & He, Q. Y. (2012). clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS, 16(5), 284-287. doi:10.1089/omi.2011.0118
Zhang, L., Chi, Y., Wei, Y., Zhang, W., Wang, F., Zhang, L., . . . Han, Z. (2021). Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality. Stem Cell Res Ther, 12(1), 365. doi:10.1186/s13287-021-02444-0
Zhou, C., Li, C., Peng, S., Zhou, L., & Li, H. (2020). Comprehensive Analysis of the Relationships Between Tumor Mutation Burden With Immune Infiltrates in Cervical Cell Carcinoma. Front Mol Biosci, 7, 582911. doi:10.3389/fmolb.2020.582911