1. Katsuyama T, Tsokos GC, Moulton VR (2018) Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus. Front Immunol 9:1088.
2. Perl A (2017) Metabolic Control of Immune System Activation in Rheumatic Diseases. Arthritis Rheumatol 69:2259-2270.
3. Menk AV, Scharping NE, Moreci RS, Zeng X, Guy C, Salvatore S, Bae H, Xie J, Young HA, Wendell SG et al (2018) Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell reports, 22:1509-1521.
4. Shin B, Benavides GA, Geng J, Koralov SB, Hu H, Darley-Usmar VM, Harrington LE (2020) Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells. Cell reports, 30:1898-1909 e1894.
5. Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
6. Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Science's STKE : signal transduction knowledge environment 2007:cm8.
7. Kuschel A, Simon P, Tug S (2012) Functional regulation of HIF-1alpha under normoxia--is there more than post-translational regulation? J Cell Physiol 227:514-524.
8. Palazon A, Goldrath AW, Nizet V, Johnson RS (2014) HIF transcription factors, inflammation, and immunity. Immunity 41:518-528.
9. Larbi A, Zelba H, Goldeck D, Pawelec G (2010) Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells. J Leukoc Biol 87:265-273.
10. Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR et al (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146:772-784.
11. Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208:1367-1376.
12. Sharabi A, Tsokos GC: T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy. (2020) Nat Rev Rheumatol 16:100-112.
13. Islam SMT, Won J, Khan M, Mannie MD, Singh I (2021) Hypoxia-inducible factor-1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases. Immunology 164:31-42.
14. Shan K, Pang R, Zhao C, Liu X, Gao W, Zhang J, Zhao D, Wang Y, Qiu W (2017) IL-17-triggered downregulation of miR-497 results in high HIF-1alpha expression and consequent IL-1beta and IL-6 production by astrocytes in EAE mice. Cell Mol Immunol 14:909-923.
15. Zhao W, Wu C, Li LJ, Fan YG, Pan HF, Tao JH, Leng RX, Ye DQ (2018) RNAi Silencing of HIF-1alpha Ameliorates Lupus Development in MRL/lpr Mice. Inflammation, 41(5):1717-1730.
16. Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W et al (2009) Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol, 182:2063-2073.
17. Clough E, Barrett T (2016) The Gene Expression Omnibus Database. Methods Mol Biol 1418:93-110.
18. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725.
19. Gladman DD, Ibanez D, Urowitz MB (2002) Systemic lupus erythematosus disease activity index 2000. J Rheumatol 29:288-291.
20. Del Rey MJ, Valin A, Usategui A, Garcia-Herrero CM, Sanchez-Arago M, Cuezva JM, Galindo M, Bravo B, Canete JD, Blanco FJ et al (2017) Hif-1alpha Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions. Sci Rep 7:3644.
21. Graumann U, Reynolds R, Steck AJ, Schaeren-Wiemers N (2003) Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol 13:554-573.
22. Ivan M, Huang X (2014) miR-210: fine-tuning the hypoxic response. Adv Exp Med Biol 772:205-227.
23. Mimouna S, Goncalves D, Barnich N, Darfeuille-Michaud A, Hofman P, Vouret-Craviari V (2011) Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses. Gut Microbes 2:335-346.
24. Loukovaara S, Koivunen P, Ingles M, Escobar J, Vento M, Andersson S (2014) Elevated protein carbonyl and HIF-1alpha levels in eyes with proliferative diabetic retinopathy. Acta ophthalmologica 92:323-327.
25. Tsokos GC, Lo MS, Costa Reis P, Sullivan KE (2016) New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol 12:716-730.
26. Vukelic M, Kono M, Tsokos GC (2020) T cell Metabolism in Lupus. Immunometabolism 2:e200009.
27. Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC (2008) Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol 180:4476-4486.
28. Garchow B, Maque Acosta Y, Kiriakidou M (2021) HIF-1alpha and miR-210 differential and lineage-specific expression in systemic lupus erythematosus. Mol Immunol 133:128-134.
29. Kono M, Yoshida N, Maeda K, Suarez-Fueyo A, Kyttaris VC, Tsokos GC (2019) Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis. Arthritis Rheumatol 71:1869-1878.
30. Wong CK, Lit LC, Tam LS, Li EK, Wong PT, Lam CW (2008) Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 127:385-393.
31. Moulton VR, Tsokos GC (2011) Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther 13:207.
32. Morel L: Immunometabolism in systemic lupus erythematosus. Nature reviews Rheumatology 2017, 13(5):280-290.
33. Caielli S, Cardenas J, de Jesus AA, Baisch J, Walters L, Blanck JP, Balasubramanian P, Stagnar C, Ohouo M, Hong S et al (2021) Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell 184:4464-4479 e4419.
34. Caielli S, Veiga DT, Balasubramanian P, Athale S, Domic B, Murat E, Banchereau R, Xu Z, Chandra M, Chung CH et al (2019) A CD4(+) T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med 25:75-81.
35. Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L (2015) Normalization of CD4+ T cell metabolism reverses lupus. Sci Transl Med 2015 7:274ra218.