1. Zhu N, Zhang D, Wang W, et al, A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. https://doi:10.1056/NEJMoa2001017
2. Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426(6965):450-454. https://doi:10.1038/nature02145
3. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel
coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS
coronavirus. J Virol. 2020;94(7), e00127-20. https://doi:10.1128/JVI.00127-20
4. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280. https://doi.org/10.1016/j.cell.2020.02.052
5. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi:10.1016/S0140-6736(20)30183-5
6. Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821), 430-436. https://doi:10.1038/s41586-020-2521-4
7. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529-539. https://doi:10.1007/s00281-017-0629-x
8. Gao YM, Xu G, Wang B, Liu BC. Cytokine storm syndrome in coronavirus disease 2019: A narrative review. J Intern Med. 2021;289(2):147-161. https://doi:10.1111/joim.13144
9. Ye Q, Wang B, Mao J. The pathogenesis and treatment of the ‘Cytokine Storm' in COVID-19. J Infect. 2020;80(6):607-613. https://doi:10.1016/j.jinf.2020.03.037
10. Li N, Zhu L, Sun L, Shao G. The effects of novel coronavirus (SARS-CoV-2) infection on cardiovascular diseases and cardiopulmonary injuries. Stem Cell Res.2021;51:102168. https://doi.org/10.21037/tlcr-21-663
11. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. https://doi:10.1056/NEJMoa2002032
12. Lee KY. Pneumonia, acute respiratory distress syndrome, and early immune-modulator therapy. Int J Mol Sci. 2017;18(2):388. https://doi:10.3390/ijms18020388
13. Zuo Y, Yalavarthi S, Shi H, et al. Neutrophil extracellular traps in COVID-19. JCI Insight. 2020;5(11):e138999. https://doi:10.1172/jci.insight.138999
14. Veras FP, Pontelli MC, Silva CM, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J Exp Med. 2020;217(12):e20201129. https://doi:10.1084/jem.20201129
15. Kadomatsu K, Tomomura M, Muramatsu T. cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun. 1988;151(3):1312-1318. https://doi:10.1016/s0006-291x(88)80505-9
16. Weckbach LT, Preissner KT, Deindl E. The role of midkine in arteriogenesis, involving mechanosensing, endothelial cell proliferation, and vasodilation. Int J Mol Sci. 2018;19(9):2559. https://doi:10.3390/ijms19092559
17. Filippou PS, Karagiannis GS, Constantinidou A. Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target. Oncogene. 2020;39(10):2040-2054. https://doi:10.1038/s41388-019-1124-8
18. Muramatsu T. Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem. 2002;132(3):359-371. https://doi:10.1093/oxfordjournals.jbchem.a003231
19. Muramatsu T. Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(4):410-425. https://doi:10.2183/pjab.86.410
20. Takada T, Toriyama K, Muramatsu H, Song XJ, Torii S, Muramatsu T. Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J Biochem. 1997;122(2):453-458. https://doi:10.1093/oxfordjournals.jbchem.a021773
21. Krzystek-Korpacka M, Diakowska D, Neubauer K, Gamian A. Circulating midkine in malignant and non-malignant colorectal diseases. Cytokine. 2013;64(1):158-164. https://doi:10.1016/j.cyto.2013.07.008
22. Shindo E, Nanki T, Kusunoki N, et al, The growth factor midkine may play a pathophysiological role in rheumatoid arthritis. Mod Rheumatol. 2017;27(1):54-59. https://doi.org/10.1080/14397595.2016.1179860
23. Zhang R, Pan Y, Fanelli V, et al. Mechanical stress and the induction of lung fibrosis via the midkine signaling pathway. Am J Respir Crit Care Med. 2015;192(3):315-323. https://doi.org/10.1164/rccm.201412-2326OC
24. Misa K, Tanino Y, Wang X, et al. Involvement of midkine in the development of pulmonary fibrosis. Physiol Rep. 2017;5(16):e13383. https://doi.org/10.14814/phy2.13383
25. Ketenci S, Aynacıoğlu AŞ. The growth factor/cytokine midkine may participate in cytokine storm and contribute to the pathogenesis of severe acute respiratory syndrome coronavirus 2-infected patients. Egypt J Bronchol. 2021;15(1), 1-6. https://doi.org/10.1186/s43168-021-00087-6
26. Arcanjo A, Logullo J, Menezes CCB, et al. The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19). Sci Rep. 2020;10(1):19630. https://doi.org/10.1038/s41598-020-76781-0
27. Reshi ML, Su YC, Hong JR. RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol. 2014;2014:467452. https://doi:10.1155/2014/467452
28. Laforge M, Elbim C, Frère C, et al. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nat Rev Immunol. 2020;20(9):515-516. https://doi.org/10.1038/s41577-020-0407-1
29. Yoshida Y, Sakakima H, Matsuda F, Ikutomo M. Midkine in repair of the injured nervous system. Br J Pharmacol. 2014;171(4):924-930. https://doi.org/10.1111/bph.12497
30. Horiba M, Kadomatsu K, Yasui K, et al. Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction. Circulation. 2006;114(16):1713-1720. https://doi.org/10.1161/CIRCULATIONAHA.106.632273
31. Kang HC, Kim IJ, Park HW, et al. Regulation of MDK expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance. Cancer Lett. 2007;247(1):40-47. https://doi.org/10.1016/j.canlet.2006.03.017
32. Weckbach LT, Gola A, Winkelmann M, et al. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18). Blood. 2014;123(12):1887-1896. https://doi.org/10.1182/blood-2013-06-510875
33. Kojima S, Muramatsu H, Amanuma H, Muramatsu T. Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem. 1995;270(16):9590-9596. https://doi.org/10.1074/jbc.270.16.9590
34. Weckbach LT, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer. Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. J Exp Med. 2019;216(2):350-368. https://doi.org/10.1084/jem.20181102
35. Kadomatsu K. Midkine regulation of the renin-angiotensin system. Curr Hypertens Rep. 2010;12(2):74-79. https://doi.org/10.1007/s11906-010-0092-8
36. Hobo A, Yuzawa Y, Kosugi T, et al. The growth factor midkine regulates the renin-angiotensin system in mice. J Clin Invest. 2009;119(6):1616-1625. https://doi.org/10.1172/JCI37249
37. Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med. 2011;364(7):656-665. https://doi.org/10.1056/NEJMra0910283
38. Jahani M, Dokaneheifard S, Mansouri K. Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm. J Inflamm (Lond). 2020;17:33. https://doi.org/10.1186/s12950-020-00263-3
39. Serebrovska ZO, Chong EY, Serebrovska TV, Tumanovska LV, Xi L. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin. 2020;41(12):1539-1546. https://doi.org/10.1038/s41401-020-00554-8
40. Taniguchi-Ponciano K, Vadillo E, Mayani H, et al, (2021) Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients. Ann Med. 2021;53(1):197-207. https://doi.org/10.1080/07853890.2020.1858234
41. Reynolds PR, Mucenski ML, Le Cras TD, Nichols WC, Whitsett JA. Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J Biol Chem. 2004;279(35):37124-37132. https://doi.org/10.1074/jbc.M405254200
42. Zhang R, Pan Y, Fanelli V, et al. Mechanical stress and the induction of lung fibrosis via the midkine signaling pathway. Am J Respir Crit Care Med. 2015;192(3):315-323. https://doi.org/10.1164/rccm.201412-2326OC
43. Chen W. A potential treatment of COVID-19 with TGF-β blockade. Int J Biol Sci. 2020;16(11), 1954–1955. https://doi.org/10.7150/ijbs.46891