Carcinoma cervix is a type of cancer that occurs in the cells of the cervix, the lower part of the uterus that connects it to the vagina. The incidence and mortality rate due to this cancer have declined in the developed countries over past few decades but still remains to be the most common gynecological cancer and fourth most common malignancy in women across developing countries [1]. In India, it is second most common cancer in females after breast cancer, with around a lakh new cases identified annually [2]. The highest incidence was recorded in Papumpare, Aizawl, Mizoram, accounting for a total of 27% of cancer cases amongst female in India [3, 4]. It accounted for 0.3% of all cancer patients and 27% of all female cancer patients seen [4]. Infection with human papillomavirus (HPV) is associated with more than 90% cases of cervix cancer [5]. Surgery, radiotherapy or chemotherapy, alone or in combination [6], can be used as therapeutic modalities for carcinoma cervix [7]. Malignant melanoma is the most dangerous form of skin cancer [8], being fifth most common tumor type among men and sixth in women in the United States [9]. In addition, malignant melanoma is 1.4 times more common among men than in women. The incidence of both non-melanoma and melanoma skin cancers have been increasing over the past decades and are reported maximum in Australia, New Zealand, Switzerland, Denmark and Norway [10]. Ultraviolet (UV) radiation and number of moles more than 100 is the greater risk for melanoma [11].
Surgery is the definitive treatment depending on number of factors, including the type of cancer, size of the lesion, anatomic location, available resources and patient preferences for early-stage melanoma, keeping or leaving medical management generally reserved as adjuvant treatment for advanced melanoma [12]. Moreover, nowadays doctors are exploring plant extracts to treat cancer, hypothesizing their traditional use because they can be used even in palliative care as well as to reduce the side effects associated with cancer treatment. The National Cancer Institute (NCI) has collected about 35,000 plant samples from 20 countries and has screened around 114,000 extracts for anticancer activity. Over 3000 species of plants with potential antitumor activity have been reported [13]. Approximately 60% of anticancer compounds and 75% drugs for infectious disease come from natural products or their derivatives [14]. One of them is Musa × paradisiaca L. commonly known as Plantain belonging to family musaceae (banana family) [15]. Native to the Mediterranean region. It possesses several medicinal properties which include antilithiatic, antibacterial, antidiabetic, antiulcer, anti-diarrheal, hypocholesterolaemic, hepatoprotective, anti-snake venom, wound healing, hair growth promoting, anti-fungal and anti-menorrhagia activity [16]. due to the presence of anti-cancer activity Musa × paradisiaca L can be prove effective against cervical carcinoma and malignant melanoma [17].