Ethics approval and consent to participate
All patient data collected in NEPOS were generated during routine care. The data collected were anonymous. No direct patient survey or sampling took place within NEPOS. No human samples were collected and send to the RKI. The Ethics Committee of the Berlin Chamber of Physicians reviewed the project and waived the need for ethical approval or informed consent, as it involves only retrospective anonymous data (Eth-KB 03/20). We confirm that all methods were performed in accordance with the relevant guidelines and regulations.
Consent for publication
Not applicable
Availability of data and materials
The datasets generated and/or analyzed during the current study are not publicly available due to data protection and confidentiality but are available from the corresponding author on reasonable request.
Competing interests
DS, MF, BB, VB, TS, MB, RR, KS, and NH declare that they have no competing interests. CK is small shareholder in companies manufacturing antiretroviral drugs. SS has received honoraria for lectures, conference sponsorship and participation on advisory boards from Abbvie, Gilead, Janssen, GSK, MSD, ViiV Healthcare, Theratechnologies. SVS has received honoraria and study compensation from companies developing and marketing antiretroviral drugs and is shareholder of various pharmaceutical companies including ones developing and marketing antiretroviral drugs.
Funding
The PrEP evaluation (EvE-PrEP) was funded by the Federal Ministry of Health, Germany. We acknowledge the financial support of the German Federal Ministry of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Authors' contributions
DS was responsible for the study design, performed the data analysis and statistical analysis, interpreted the data and drafted the manuscript. CK contributed to the conception of the study and interpretation of the data and was responsible for the data management. KS, RR and NH contributed to the conception and coordination of the study and interpretation of the data and to draft the manuscript. MF and TS supported the management and coordination of the study and contributed to improving the data quality and coverage. SS, SVS, MB are site principal investigators, contributed data and supported the interpretation of the data. VB and BB supported the management and coordination of the study and the overall study design and analysis approach. All authors participated in the critical discussion of the results, and all read and approved the final manuscript.
Acknowledgements
The authors are grateful to the PrEP users and to all collaborative NEPOS centers for the data collection and study management in the centers. The authors would like to thank Andrea Sailer for her assistance in the preparation of figure 1 and Matthias an der Heiden for his support with the logistic regression analyses. We thank all cooperating partners in EvE-PrEP.
The NEPOS study group
Aachen: Heribert Knechten, Petra Panstruga (Praxis Dr. Knechten, Aachen);
Berlin: Axel Baumgarten, Bianca Reisenweber (Zentrum für Infektiologie Berlin Prenzlauer Berg, ZIBP, Berlin); Heribert Hillenbrand, Kai Zucker (MVZ Praxis City Ost, Berlin); Siegfried Köppe, Marc Da Silva Ribeiro, (Internistische GP Dres. Köppe und Kreckel, Berlin); Ivanka Krznaric, Denis Pitan (Praxis an der Kulturbrauerei, Berlin); Christian Lieb, Hussen Yasin (Praxis Goldstein, Berlin); Ingo Ochlast, Irina Shnurenko (Praxisteam Friedrichshain, Berlin); Michael Rausch, Svetlana Krasov (MVZ Praxis Schöneberg, Berlin); Sven Schellberg, Peter Stueber (Novopraxis, Berlin); Dietmar Schranz, Michael Rittweger (Praxis Wilmersdorfer Dres. Schranz, Fischer und Rittweger, Berlin); Hubert Schulbin, Adam Smiley (Praxis Kreuzberg, Berlin); Kevin Ummard-Berger, Andreas Berger (UBN Praxis, Berlin); Johannes Lenz (Praxis Turmstraße, Berlin);
Bonn: Chistoph Boesecke, Martha Oberschlep (Uniklilnik Bonn, Ambulanz für Infektiologie & Immunologie Med. Klinik und Poliklinik, Bonn);
Bremen: Susann Koch, Mareen Monsees (Praxis für Onkologie und Infektiologie, Bremen);
Chemnitz: Thomas Heuchel, Manuela Richter (Praxis Dr. Heuchel, Chemnitz);
Dortmund: Andreas Bellmunt-Zschäpe, Jutta Hahn (Praxis Bellmunt Zschäpe, Dortmund);
Dresden: Andreas Jenke, Stefan Pursche (Praxis Dr. Jenke, Dresden);
Düsseldorf: Stefan Mauss, Florian Berger (MVZ für Leber-, Magen-, Darm, Infektions- und Krebserkrankungen, Düsseldorf);
Frankfurt: Marcus Bickel, Monja Rößler, (Infektiologikum Frankfurt, Frankfurt); Anette Haberl, Peter Schott (HIVCENTER Klinikum der Johann Wolfgang-Goethe-Universität Zentrum der Inneren Med. II, Frankfurt), Pavel Khaykin, Michaela Bracone (GP Dres. Manfred Mösch und Pavel Khaykin, Frankfurt);
Freiburg: Susanne Usadel, Tina Mattmüller (Zweigpraxis der MVZ Clotten GbR, Freiburg)
Gießen: Georg Friese, Ulrike Kratz (Dr. med. Cseke und Dr. med. Friese Hausärztlich Internistische GP, Gießen)
Hamburg: Sandra Hertling, Dirk Berzow (Praxisgemeinschaft Dr.Dirk Berzow, Andreas Christl und Dr. Sandra Hertling, Hamburg); Knud Schewe, Constantin Rickassel ICH Hamburg–Stendal GbR/ ICH Stadtmitte, Hamburg);
Hannover: Hans Heiken (Praxis Georgstraße, Hannover)
Koblenz: Ansgar Rieke, Petra Becker (Gemeinschaftsklinikum Mittelrhein gGmbH, Akademisches Lehrkrankenhaus der Universitätsmedizin der Johannes Gutenberg-Universität Mainz Kemperhof, Immunologische Ambulanz, Koblenz);
Köln: Katja Römer, (GP Gotenring, Köln); Stefan Scholten, Andreas Roder (Praxis Hohenstaufenring Dr. Scholten & Schneeweiß GbR, Köln); Christoph Wyen, Kerstin Lammersmann (Praxis am Ebertplatz, Köln);
Leipzig: Ines Ruck (Praxis Dr.med. Ines Ruck, Leipzig);
Mainz: Burkhard Schappert (Allgemeinmedizinische Praxis Prof. Dr. B. Schappert, O. Gangaev, Mainz);
München: Ulrich Kastenbauer (Praxis Dr. Ulrich Kastenbauer, München); Ramona Pauli, Oskar Mikazans (Isarpraxis Dres. Becker, Pauli, Lee und Dialer, München); Farhad Schabaz (MVZ München am Goetheplatz, München); Christoph Spinner, Stefanie Gladis (Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der TUM, München);
Münster: Stefan Christensen, Sabine Offermann (Infektiologische Praxisgemeinschaft Dr. med. H. W. Busch, Dr. med. St. Christensen, Münster);
Neuss: Robert Baumann (GP Dr. med. R. Baumann und Dr. med. Florian Sels, Neuss);
Osnabrück: Niels Schübel, Anja Lüssenheide, (Klinikum Osnabrück, infektiologisches Zentrum, Osnabrück);
Regensburg: Franz Audebert, Elisabeta Sepsy (Praxiszentrum Alte Mälzerei, Regensburg);
Saarbrücken: Beatrice Gospodinov, Aynur Bulut (GP für Allgemeinmedizin Béatrice Gospodinov & Katarina Projsner, Saarbrücken);
Stuttgart: Patrick Beck, Jennifer Weida (GP Schwabstrasse 59, Stuttgart);
Ulm: Georg Härter, Petra Schütz (Medicover Ulm MVZ, Ulm);
Weimar: Thomas Seidel (MEDCENTER Weimar, Dr. med. Seidel Innere Medizin, hausärztl. Versorgung, Infektiologie, Weimar);
Wuppertal: Sabine Mauruschat (Praxis für Allgemein- und Suchtmedizin, Substitutionsbehandlungen und Infektiologie, Wuppertal)
Zwickau: Steve Rößler; (Arztpraxis Steve Rößler, Zwickau)