Caffeine in the intensive care unit
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Caffeine withdrawal and administration on the incidence of post-operative headache or delirium
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2015
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USA
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Prospective survey
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25 intensive care units across 17 institutions
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Caffeine intake minimisation was used in 32% of intensive care units as a pharmacological method to reduce delirium
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20
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Caffeine withdrawal and administration on induction and emergence from sedation
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2017
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Iran
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Prospective RCT
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80 patients;
40 coffee, 40 placebo
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3.5 g coffee given via nasogastric tube in the mechanically ventilated patients increases the spontaneous respiratory rate and tidal volume but does not significantly affect other respiratory indicators.
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21
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Safety and changes associated with caffeine administration
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1987
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Germany
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Prospective observational
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12 male patients
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Quinolones can inhibit the metabolism of caffeine and may cause higher levels of circulating caffeine and side effects
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22
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1995
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Spain
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Prospective cohort
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Liver impaired 33; normal liver 40
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healthy individuals metabolise 3 mg IV caffeine faster than those with liver disease
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23
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Caffeine in the peri-operative period
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Caffeine withdrawal and administration on the incidence of post-operative headache or delirium
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2017
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Greece
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Prospective cohort
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446 elective surgery patients
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In patients with no previous history of headache, caffeine consumption was an additional independent factor for postoperative headache
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24
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1994
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Denmark
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Prospective observational
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219 elective patients
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The risk of post-operative headache was significantly greater in individuals with a daily caffeine intake > 400 mg/day
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25
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2003
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United Kingdom
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Prospective observational
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208 day patients
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Caffeine is not a risk factor for peri-operative headache
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26
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1989
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New Zealand
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Prospective survey
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150 day case patients
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Patient who consume > 200 mg caffeine/day were 3-fold more likely to have a headache post-operatively compared to those who did not
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27
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1990
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Netherlands
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Prospective survey
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334 GA + 75 LA
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There was no difference between incidence of headache between GA or LA alone. Caffeine intake was not a risk factor for developing headache postoperatively.
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28
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1991
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New Zealand
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Prospective survey
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287 patients undergoing minor elective surgery
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postoperative headache is related to caffeine intake and that this relationship is explained at least in part, by a perioperative caffeine withdrawal syndrome
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29
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1993
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USA
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Prospective survey
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233 surgical outpatients
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Among daily caffeine drinkers, those who drank caffeinated beverages on the day of the surgical procedure had a lower incidence of postoperative headaches than did those who abstained (17% versus 28%; P < 0.04)
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30
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1994
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Switzerland
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Case report
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Elective open abdominal surgery for oophorectomy
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28F with post-operative headache, hemihypaesthesia, cerebral oedema on CT-Head which resolved with caffeine/ergometrine
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31
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1995
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Switzerland
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Prospective RCT
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40 patients;
20 caffeine, 20 placebo
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Surgical patients who have high caffeine intake were randomised to taking oral caffeine tablets or placebo. No patients on caffeine supplements develop headaches while 10 (50%) on placebo developed headaches which lasted up to 7 days.
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32
|
1997
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USA
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Prospective RCT
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234 elective surgical patients
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prophylactic postoperative 200 mg IV caffeine decreased the incidence of headache
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33
|
Caffeine withdrawal and administration on induction and emergence from anaesthesia
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2019
|
United Kingdom
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Prospective observational
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40 ASA 1 individuals
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high daily caffeine intake is associated with lower propofol requirements for induction. We hypothesise that those with high daily caffeine intake have lower arousal levels before surgery, because of a relative caffeine deficit secondary to being nil-by-mouth
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38
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1984
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USA
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Prospective RCT
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60 patients undergoing CABG
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Patients who drank > 3 cups of coffee/day, smoke > 40 cigarettes/day and drank 1–3 ounces of alcohol required more fentanyl at induction for their CABG operation
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39
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1984
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Australia
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Prospective observational
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23 patients + 23 controls
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High caffeine intake resulted in worse cognitive functioning post anaesthetic compared to low caffeine intake
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45
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2011
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USA
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Case report
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Elective tumour resection
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The use of 500 mg IV caffeine intra-operatively to ensure the patient is responsive enough to perform intraoperative language mapping. Frequent stimulation-induced seizures thereafter limited further testing.
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40
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2017
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USA
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Case report
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Elective dental procedure
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Use of 60 mg IV caffeine in an 16yo male with trisomy 10 with a history of slow emergence from anaesthesia to speed up emergence from anaesthesia and as a respiratory stimulant
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41
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2010
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Egypt
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Prospective RCT
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60 patients
30 caffeine, 30 control
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Administration of 500 mg IV caffeine decreases the number of patients who developed adverse post extubation respiratory events and hastens recovery from sevoflurane anaesthesia.
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44
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2018
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USA
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Prospective RCT
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8 males patients
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15 mg/kg IV caffeine is able to accelerate emergence from isoflurane anaesthesia in healthy males without any apparent adverse effects
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42
|
2018
|
USA
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Retrospective observational
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151 heavily sedated patients in the post-anaesthesia recovery area
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Median of 150 mg IV caffeine may enhance the speed of recovery following general anaesthesia without any respiratory or cardiovascular changes
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43
|
Safety and changes associated with caffeine administration
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1996
|
USA
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Prospective survey
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882 nurses surveyed
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85% of responders would withhold caffeine in patients after an acute myocardial infarction as a part of coronary precautions
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34
|
2013
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USA
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Prospective RCT
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30 patients
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Ingestion of 102 mg of caffeine (drip coffee) can increase spontaneous voiding post indwelling bladder catheter removal
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35
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2013
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USA
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Prospective RCT
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62 patients
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500 mg IV caffeine given intra-operatively resulted in increased nausea, and there was no difference in post-operative headache, fatigue, time to discharge
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36
|
2018
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France
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Prospective RCT
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110 patients booked for heart valve surgery
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400 mg caffeine q8h does not affect postoperative AF but does increase the risk of nausea and vomiting
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37
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