Background and Objective: Pregnancy has undesirable effects on women lives which lead to reduction in quality of life. Assessment of Quality of Life is necessary among pregnant women because of association with the various complications. Hence, the present study was conducted to evaluate the patient’s health-related quality of life during complications of pregnancy. Method: A prospective observational single centered study was conducted on 81 pregnant women who were diagnosed with complications (Anemia, UTI, Pre-eclampsia and Hyperemesis gravid arum) in Obstetrics & Gynecology department of NIMS Hospital, Jaipur, (Rajasthan). Result: The mean score of physical component scale (PCS) and mental component scale (MCS) was found to be 58.43±0.70 and 75.8±1.25 respectively. The mean score at the time of discharge were physical functioning 69.8±13.77, role limitation due to physical problems 79.01±16.15, role limitation due to emotional problems 68.00±17.10, vitality 48.68±7.30, mental health 98.64±4.25, social functioning 87.22±18.71, bodily pain 80.61±12.67, general health 72.5±4.06 and reported health transition 82.71±12.89 and overall score at p-value was found to be significant. Conclusion: HRQoL of pregnant women associated with complications has been improved where mental health tends to recover more quickly than physical health. Keywords: Quality of Life; Anemia; UTI; Pre-eclampsia; Hyperemesis gravidarum.