Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, Ferrara N, King GL, Smith LE (1995) Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 92:10457–10461
Alitalo K, Carmeliet P (2002) Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1:219–227
Belem MA, Lee BH (1998) Production of bioingredients from Kluyveromyces marxianus grown on whey; an alternative. Crit Rev Food Sci Nutr 38:565–598
Bonekamp FJ, Oosterom J (1994) On the safety of Kluyveromyces lactis: a review. Appl Microbiol Biotechnol 41:1–3
Boocock CA, Charnock-Jones DS, Sharkey AM, McLaren J, Barker PJ, Wright KA, Twentyman PR, Smith SK (1995) Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 87(7):506–516
Catena R, Larzabal L, Larrayoz M, Molina E, Hermida J, Agorreta J, Montes R, Pio R, Montuenga L, Calvo A (2010) VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A. Mol Cancer 9:320
Chen X, Gao B, Shi W, Li Y (1992) Expression and secretion of human interferon alpha A in yeast Kluyveromyces lactis. Yi Chuan Xue Bao 19:284–288
Chintalgattu V, Nair DM, Katwa LC (2003) Cardiac myofibroblasts: A novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR. J Mol Cell Cardiol 35:277–286
Chung ND, Kim NS, Giap do V, Jang SH, Oh SM, Jang SH, Kim TG, Jang YS, Yang MS (2014) Production of functional human vascular endothelial growth factor (165) in transgenic rice cell suspension cultures. Enzyme Microb Technol 63:58–63
Colussi PA, Specht CA, Taron CH (2005) Characterization of a nucleus-encoded chitinase from the yeast Kluyveromyces lactis. Appl Environ Microbiol 71:2862–2869
Dujon B, Sherman D, Fisher G (2004) Genome evolution in yeasts. Nature 430:35–44
Dvorak HF, Detmar M, Claffey KP, Nagy JA, van de Water L, Senger DR (1995) Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int Arch Allergy Immunol 107:233–235.
Dvorak HF (2006) Discovery of vascular permeability factor (VPF). Exp Cell Res 312:522–526
Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161(2):851–858
Ferrara N, Houck KA, Jakeman LB, Winer J, Leung DW (1991) The vascular endothelial growth factor family of polypeptides. J Cell Biochem 47:211–218
Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380(6573):439–442
Ferrara N (2004) Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25:581–611
Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438:967–974
Gardner V, Madu C, Lu Y (2017) In Physiologic and Pathologic Angiogenesis. Signaling Mechanisms and Targeted Therapy In: Simionescu D (ed) Anti-VEGF Therapy in Cancer: A Double-Edged Sword, InTechOpen, London
Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N (1999) VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5(6):623–628
Ghaly AE, Kamal M & Correia LR (2005) Kinetic modeling of continuous submerged fermentation of cheese whey for single cell protein production. Bioresour Technol 96: 1143–1152
Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59:3374–3378
Feng YM, Zhang BY, Zhang YS, Hiroshi F (1997) Secretory Expression of Porcine Insulin Precursor in Kluyveromyces lactis and Its Conversion into Human Insulin. Sheng wu hua xue yu Sheng wu wu li xue bao Acta Biochimica et Biophysica Sinica 29(2):129–134
Fiebich BL, Jager B, Schollmann C, Weindel K, Wilting J, Kochs G, Marme D, Hug H, Weich HA (1993) Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells. Eur J Biochem 211:19–26
Fleer R, Chen XJ, Amellal N, Yeh P, Fournier A, Guinet F, Gault N, Faucher D, Folliard F & Fukuhara H (1991a) High-level secretion of correctly processed recombinant human interleukin-1 beta in Kluyveromyces lactis. Gene 107:25–295
Frank S, Hübner G, Breier G, Longaker MT, Greenhalgh DG, Werner S (1995) Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem 270(21):12607–12613
Harju S, Fedosyuk H, Peterson KR (2004) Rapid isolation of yeast genomic DNA: Bust n' Grab. BMC Biotechnol 4:8
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA (2004) Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 56:549–580
Holmes DI, Zachary I (2005) The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 6(2):209
Hua Z, Liang X, Zhu D (1994) Expression and purification of a truncated macrophage colony stimulating factor in Kluyveromyces lactis. Biochem Mol Biol Int 34(2):419–427
Iijima K, Yoshikawa N, Connolly DT, Nakamura H (1993) Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor. Kidney Int 44(5):959–966
Kang WK, Lee MH, Kim YH, Kim MY, Kim JY (2013) Enhanced secretion of biologically active, non-glycosylated VEGF from Saccharomyces cerevisiae. J Biotechnol 164(4):441–448
Keck RG, Berleau L, Harris R, Keyt BA (1997) Disulfide structure of the heparin binding domain in vascular endothelial growth factor: characterization of posttranslational modifications in VEGF. Arch Biochem Biophys 344(1):103–113
Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R, Ferrara N (1996) The carboxyl-terminal domain (111–165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 271:7788–7795
Kim HJ, Kim, HJ (2016) Yeast as an expression system for producing virus-like particles: What factors do we need to consider? Letters in Applied Microbiology 64:111–123
Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685
Lauer G, Sollberg S, Cole M, Krieg T, Eming SA (2002) Generation of a novel proteolysis resistant VEGF165 variant by a site-directed mutation at the plasmin sensitive cleavage site. FEBS Lett 531:309–313
Lee SS, Joo YS, Kim WU, Min DJ, Min JK, Park SH, Cho CS, Kim HY (2001) Vascular endothelial growth factor levels in the serum and synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol 19:321–324
Lee GY, Jung WW, Kang CS, Bang IS (2006) Expression and characterization of human vascular endothelial growth factor (VEGF165) in insect cells. Protein Expr Purif 46(2):503–509
Lee SB, Park JS, Lee S, Park J, Yu S, Kim H, Kim D, Byun TH, Baek K, Ahn YJ, Yoon J (2008) Overproduction of recombinant human VEGF (vascular endothelial growth factor) in Chinese hamster ovary cells. J Microbiol Biotechnol 18(1):183–187
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306–1309
Li X, Eriksson U (2001) Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D. Int J Biochem Cell Biol 33:421–426
Mohanraj D, Olson T, Ramakrishnan S (1995) Expression of biologically active human vascular endothelial growth factor in yeast. Growth Factors 12(1):17–27
Nguyen MT, Krupa M, Koo B-K, Song J-A, Vu TTT, Do BH, Nguyen AG, Seo T, Yoo J, Jeong B, Jin J, Lee KJ, Oh HB, Choe H (2016) Correction: Prokaryotic Soluble Overexpression and Purification of Human VEGF165 by Fusion to a Maltose Binding Protein Tag. PloS ONE 11(5):e0156296
Oishi H, Morimoto T,Watanabe Y, Tamai Y (1999) Purification and characterization of phospholipase B from Kluyveromyces lactis, and cloning of phospholipase B. Biosci Biotechnol Biochem 63:83–90
Peretz D, Gitay-Goren H, Safran M, Kimmel N, Gospodarowicz D, Neufeld G (1992) Glycosylation of vascular endothelial growth factor is not required for its mitogenic activity. Biochem Biophys Res Commun 182:1340–1347
Pizarro SA, Gunson J, Field MJ, Dinges R, Khoo S, Dalal M, Lee M, Kaleas KA, Moiseff K, Garnick S, Reilly DE, Laird MW, Schmelzer CH (2010) High-yield expression of human vascular endothelial growth factor VEGF165 in Escherichia coli and purification for therapeutic applications. Protein Expr Purif 72:184–193
Porro D, Bianchi MM, Brambilla L (1999) Replacement of a metabolic pathway for large-scale production of lactic acid from engineered yeasts. Appl Environ Microbiol 65:4211–4215
Reichardt LF, Tomaselli KJ (1991) Extracellular matrix molecules and their receptors: Functions in neural development. Annu Rev Neurosci 14:531–570
Riedel F, Gotte K, Goessler U, Sadick H, Hormann K (2004) Targeting chemotherapy-induced VEGF up-regulation by VEGF antisense oligonucleotides in HNSCC cell lines. Anticancer Res 24:2179–2183
Rocha TL, Paterson G, Crimmins K, Boyd A, Sawyer L, Fothergill-Gilmore LA (1996) Expression and secretion of recombinant ovine beta-lactuglobulin in Saccharomyces cerevisiae and Kluyveromyces lactis. Biochem J 313:927–932
Rocha S, Abrahao-Neto J, Cerdan M, Gombert A, Gonzalez-Siso M (2011) Heterologous expression of a thermophilic esterase in Kluyveromyces yeasts. Appl Microbiol Biotechnol 89(2):375–385
Rosa J, Colombo L, Alvim M, Avonce N, van Dijck P, Passos F (2013) Metabolic engineering of Kluyveromyces lactis for l-ascorbic acid (vitaminC) biosynthesis. Microb Cell Fact 12, 59
Scott PA, Gleadle JM, Bicknell R, Harris AL (1998) Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines. Int J Cancer 75:706–712
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983–985
Shibuya M (1995) Role of VEGF-Flt receptor system in normal and tumor angiogenesis. Adv Cancer Res 67:281–316
Shibuya M (2003) Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E. Cancer Sci 94:751–756
Shibuya M, Claesson-Welsh L (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 312:549–560
Spohner SC, Schaum V, Quitmann H, Czermak P (2016) Kluyveromyces lactis: An emerging tool in biotechnology. Journal of Biotechnology 222:104–116
Sunderkötter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C (1994) Macrophages and angiogenesis. J Leukoc Biol 55(3):410–422
Swennen D, Paul M, Vernis L, Beckerich J, Fournier A, Gaillardin C (2002) Secretion of active anti-Ras single-chain Fv antibody by the yeasts Yarrowia ipolytica and Kluyveromyces lactis. Microbiology 148(Pt 1):41–50
Takahashi H, Shibuya M (2005) The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci 109:227–241
Taktak-BenAmar A, Morjen M, Ben Mabrouk H, Abdelmaksoud-Dammak R, Guerfali M, Fourati-Masmoudi N, Marrakchi N, Gargouri A (2017) Expression, purification and functionality of bioactive recombinant human vascular endothelial growth factor VEGF165 in E. coli. AMB Express 7(1):33
Tammela T, Enholm B, Alitalo K, Paavonen K (2005) The biology of vascular endothelial growth factors. Cardiovasc Res 65:550–563
Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA (1991) The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266:11947–11954
Verheul HM, Hoekman K, Luykx-de Bakker S, Eekman CA, Folman CC, Broxterman HJ, Pinedo HM (1997) Platelet: transporter of vascular endothelial growth factor. Clin Cancer Res. 3(12 Pt 1):2187–2190
Wu X, Yin Z, Cao C, Huang L, Lu X, Liu J, Cui W (2004) Expression of human VEGF165 in silkworm (Bombyx mori L.) by using a recombinant baculovirus and its bioactivity assay. J Biotechnol 111(3):253–61
Xia Y-P, Li B, Hylton D, Detmar M, Yancopoulos GD, Rudge JS (2003) Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 102:161–168