1 Bedford, P. D. Adverse cerebral effects of anaesthesia on old people. Lancet 269, 259-263, doi:10.1016/s0140-6736(55)92689-1 (1955).
2 Cibelli, M. et al. Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol 68, 360-368, doi:10.1002/ana.22082 (2010).
3 Terrando, N. et al. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A 107, 20518-20522, doi:10.1073/pnas.1014557107 (2010).
4 Tian, A. et al. Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering beta-Amyloid Accumulation via the Transforming Growth Factor-beta (TGFbeta)/Smad Signaling Pathway. PLoS One 10, e0141596, doi:10.1371/journal.pone.0141596 (2015).
5 Hu, N. et al. Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane. Neurotoxicology 49, 94-103, doi:10.1016/j.neuro.2015.05.010 (2015).
6 Jia, M. et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, attenuates postoperative cognitive dysfunction in aging mice. Front Mol Neurosci 8, 52, doi:10.3389/fnmol.2015.00052 (2015).
7 Rundshagen, I. Postoperative cognitive dysfunction. Dtsch Arztebl Int 111, 119-125, doi:10.3238/arztebl.2014.0119 (2014).
8 Monk, T. G. et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 108, 18-30, doi:10.1097/01.anes.0000296071.19434.1e (2008).
9 Shultz, C. L. et al. Multimodal Analgesia in Orthopaedic Surgery and Presentation of a Comprehensive Postoperative Pain Protocol: A Review. UNM Orthopaedic Research Journal 8, 34-44 (2019).
10 Rodger, K. T., Greasley-Adams, C., Hodge, Z. & Reynish, E. Expert opinion on the management of pain in hospitalised older patients with cognitive impairment: a mixed methods analysis of a national survey. BMC Geriatr 15, 56, doi:10.1186/s12877-015-0056-6 (2015).
11 Ara, K. & Ahmad, K. Uptake of paracetamol into brain and liver of rats. Bangladesh Med Res Counc Bull 6, 39-44 (1980).
12 Courad, J. P. et al. Acetaminophen distribution in the rat central nervous system. Life Sci 69, 1455-1464, doi:10.1016/s0024-3205(01)01228-0 (2001).
13 Kumpulainen, E. et al. Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration. Pediatrics 119, 766-771, doi:10.1542/peds.2006-3378 (2007).
14 Flower, R. J. & Vane, J. R. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240, 410-411, doi:10.1038/240410a0 (1972).
15 Ottani, A., Leone, S., Sandrini, M., Ferrari, A. & Bertolini, A. The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors. Eur J Pharmacol 531, 280-281, doi:10.1016/j.ejphar.2005.12.015 (2006).
16 Zygmunt, P. M., Chuang, H., Movahed, P., Julius, D. & Hogestatt, E. D. The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396, 39-42, doi:10.1016/s0014-2999(00)00207-7 (2000).
17 Bisaglia, M. et al. Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation. Neurochem Int 41, 43-54, doi:10.1016/s0197-0186(01)00136-x (2002).
18 Pitchaimani, V. et al. Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats. J Clin Biochem Nutr 50, 241-244, doi:10.3164/jcbn.11-73 (2012).
19 Dent, E. W. Of microtubules and memory: implications for microtubule dynamics in dendrites and spines. Mol Biol Cell 28, 1-8, doi:10.1091/mbc.E15-11-0769 (2017).
20 Callaghan, C. K. et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology 63, 890-897, doi:10.1016/j.neuropharm.2012.06.034 (2012).
21 Li Hegner, Y., Lee, Y., Grodd, W. & Braun, C. Comparing tactile pattern and vibrotactile frequency discrimination: a human FMRI study. J Neurophysiol 103, 3115-3122, doi:10.1152/jn.00940.2009 (2010).
22 Culley, D. J., Baxter, M. G., Crosby, C. A., Yukhananov, R. & Crosby, G. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg 99, 1393-1397; table of contents, doi:10.1213/01.ANE.0000135408.14319.CC (2004).
23 Su, D. et al. Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil. PLoS One 6, e27632, doi:10.1371/journal.pone.0027632 (2011).
24 Rosczyk, H. A., Sparkman, N. L. & Johnson, R. W. Neuroinflammation and cognitive function in aged mice following minor surgery. Exp Gerontol 43, 840-846, doi:10.1016/j.exger.2008.06.004 (2008).
25 Goecke, J. C., Awad, H., Lawson, J. C. & Boivin, G. P. Evaluating postoperative analgesics in mice using telemetry. Comp Med 55, 37-44 (2005).
26 Curtin, L. I. et al. Evaluation of buprenorphine in a postoperative pain model in rats. Comp Med 59, 60-71 (2009).
27 Bianchi, M. & Panerai, A. E. The dose-related effects of paracetamol on hyperalgesia and nociception in the rat. Br J Pharmacol 117, 130-132, doi:10.1111/j.1476-5381.1996.tb15164.x (1996).
28 Mintzer, M. Z., Correia, C. J. & Strain, E. C. A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers. Drug Alcohol Depend 74, 205-209, doi:10.1016/j.drugalcdep.2003.12.008 (2004).
29 Messinis, L. et al. Neuropsychological functioning in buprenorphine maintained patients versus abstinent heroin abusers on naltrexone hydrochloride therapy. Hum Psychopharmacol 24, 524-531, doi:10.1002/hup.1050 (2009).
30 Pickering, G., Macian, N., Dubray, C. & Pereira, B. Paracetamol sharpens reflection and spatial memory: a double-blind randomized controlled study in healthy volunteers. Drug Des Devel Ther 10, 3969-3976, doi:10.2147/DDDT.S111590 (2016).
31 Al-Mousawi, A. M. et al. Impact of anesthesia, analgesia, and euthanasia technique on the inflammatory cytokine profile in a rodent model of severe burn injury. Shock 34, 261-268, doi:10.1097/shk.0b013e3181d8e2a6 (2010).
32 Groth, M., Kristensen, A., Ovlisen, K. & Tranholm, M. Buprenorphine does not impact the inflammatory response in haemophilia A mice with experimentally-induced haemarthrosis. Lab Anim 48, 225-236, doi:10.1177/0023677214524381 (2014).
33 Zhang, S. et al. Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption. Behav Brain Res 298, 158-166, doi:10.1016/j.bbr.2015.11.003 (2016).
34 McCoy, M. K. & Tansey, M. G. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5, 45, doi:10.1186/1742-2094-5-45 (2008).
35 Rizzo, F. R. et al. Tumor Necrosis Factor and Interleukin-1beta Modulate Synaptic Plasticity during Neuroinflammation. Neural Plast 2018, 8430123, doi:10.1155/2018/8430123 (2018).
36 Wall, A. M., Mukandala, G., Greig, N. H. & O'Connor, J. J. Tumor necrosis factor-alpha potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia. J Neurosci Res 93, 815-829, doi:10.1002/jnr.23540 (2015).
37 Pettigrew, L. C., Kryscio, R. J. & Norris, C. M. The TNFalpha-Transgenic Rat: Hippocampal Synaptic Integrity, Cognition, Function, and Post-Ischemic Cell Loss. PLoS One 11, e0154721, doi:10.1371/journal.pone.0154721 (2016).
38 Hogestatt, E. D. et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem 280, 31405-31412, doi:10.1074/jbc.M501489200 (2005).
39 Ghanem, C. I., Perez, M. J., Manautou, J. E. & Mottino, A. D. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol Res 109, 119-131, doi:10.1016/j.phrs.2016.02.020 (2016).
40 Rossi, S. et al. Cannabinoid CB1 receptors regulate neuronal TNF-alpha effects in experimental autoimmune encephalomyelitis. Brain Behav Immun 25, 1242-1248, doi:10.1016/j.bbi.2011.03.017 (2011).
41 Glass, G. E. et al. TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells. Proc Natl Acad Sci U S A 108, 1585-1590, doi:10.1073/pnas.1018501108 (2011).
42 Takatsu, K. Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci 87, 463-485, doi:10.2183/pjab.87.463 (2011).
43 Junttila, I. S. Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes. Front Immunol 9, 888, doi:10.3389/fimmu.2018.00888 (2018).
44 Lochmatter, P., Beeler, A., Kawabata, T. T., Gerber, B. O. & Pichler, W. J. Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity. Allergy 64, 1269-1278, doi:10.1111/j.1398-9995.2009.01985.x (2009).
45 Mori, S., Maher, P. & Conti, B. Neuroimmunology of the Interleukins 13 and 4. Brain Sci 6, doi:10.3390/brainsci6020018 (2016).
46 Yu, J. T. et al. Maintenance of anti-inflammatory cytokines and reduction of glial activation in the ischemic hippocampal CA1 region preconditioned with lipopolysaccharide. J Neurol Sci 296, 69-78, doi:10.1016/j.jns.2010.06.004 (2010).
47 O'Garra, A. & Vieira, P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 7, 425-428, doi:10.1038/nri2097 (2007).
48 Hemshekhar, M., Anaparti, V., Hitchon, C. & Mookherjee, N. Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis. Mediators Inflamm 2017, 2515408, doi:10.1155/2017/2515408 (2017).
49 Lobo-Silva, D., Carriche, G. M., Castro, A. G., Roque, S. & Saraiva, M. Balancing the immune response in the brain: IL-10 and its regulation. J Neuroinflammation 13, 297, doi:10.1186/s12974-016-0763-8 (2016).
50 Balasingam, V. & Yong, V. W. Attenuation of astroglial reactivity by interleukin-10. J Neurosci 16, 2945-2955 (1996).
51 Ledeboer, A. et al. Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells. Eur J Neurosci 16, 1175-1185, doi:10.1046/j.1460-9568.2002.02200.x (2002).
52 Zhou, Z., Peng, X., Insolera, R., Fink, D. J. & Mata, M. IL-10 promotes neuronal survival following spinal cord injury. Exp Neurol 220, 183-190, doi:10.1016/j.expneurol.2009.08.018 (2009).
53 Zhou, Z., Peng, X., Insolera, R., Fink, D. J. & Mata, M. Interleukin-10 provides direct trophic support to neurons. J Neurochem 110, 1617-1627, doi:10.1111/j.1471-4159.2009.06263.x (2009).
54 Pereira, L. et al. IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity. Front Cell Neurosci 9, 57, doi:10.3389/fncel.2015.00057 (2015).
55 Barra, H. S., Arce, C. A. & Argarana, C. E. Posttranslational tyrosination/detyrosination of tubulin. Mol Neurobiol 2, 133-153, doi:10.1007/BF02935343 (1988).
56 Ersfeld, K. et al. Characterization of the tubulin-tyrosine ligase. J Cell Biol 120, 725-732, doi:10.1083/jcb.120.3.725 (1993).
57 Bianchi, M. & Baulieu, E. E. 3beta-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders. Proc Natl Acad Sci U S A 109, 1713-1718, doi:10.1073/pnas.1121485109 (2012).
58 Ladurelle, N. et al. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 221, 493-509, doi:10.1007/s00213-011-2597-5 (2012).
59 Gundersen, G. G., Kalnoski, M. H. & Bulinski, J. C. Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo. Cell 38, 779-789, doi:10.1016/0092-8674(84)90273-3 (1984).
60 Kreis, T. E. Microtubules containing detyrosinated tubulin are less dynamic. EMBO J 6, 2597-2606 (1987).
61 Cumming, R., Burgoyne, R. D. & Lytton, N. A. Immunofluorescence distribution of alpha tubulin, beta tubulin and microtubule-associated protein 2 during in vitro maturation of cerebellar granule cell neurones. Neuroscience 12, 775-782, doi:10.1016/0306-4522(84)90169-6 (1984).
62 Paturle-Lafanechere, L. et al. Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. J Cell Sci 107 ( Pt 6), 1529-1543 (1994).
63 Bianchi, M. et al. Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus. Eur J Neurosci 24, 2894-2902, doi:10.1111/j.1460-9568.2006.05170.x (2006).
64 Zhang, F. et al. Posttranslational modifications of alpha-tubulin in alzheimer disease. Transl Neurodegener 4, 9, doi:10.1186/s40035-015-0030-4 (2015).
65 Erck, C. et al. A vital role of tubulin-tyrosine-ligase for neuronal organization. Proc Natl Acad Sci U S A 102, 7853-7858, doi:10.1073/pnas.0409626102 (2005).
66 Janke, C. & Kneussel, M. Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci 33, 362-372, doi:10.1016/j.tins.2010.05.001 (2010).
67 Minville, V., Fourcade, O., Mazoit, J. X., Girolami, J. P. & Tack, I. Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain. Br J Anaesth 106, 112-118, doi:10.1093/bja/aeq277 (2011).
68 Zhang, J., Jiang, W. & Zuo, Z. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor kappaB. Neuroscience 261, 1-10, doi:10.1016/j.neuroscience.2013.12.034 (2014).
69 Harry, L. E. et al. Comparison of the healing of open tibial fractures covered with either muscle or fasciocutaneous tissue in a murine model. J Orthop Res 26, 1238-1244, doi:10.1002/jor.20649 (2008).
70 Vizcaychipi, M. P. et al. Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. PLoS One 6, e26394, doi:10.1371/journal.pone.0026394 (2011).