Soilless cultivation systems that provide plant management in soilless conditions in which the supply of water and of minerals is carried out by nutrient solution, with or without a growing medium. The main aim of this paper was to investigate the possibility of growing basil under three soilless systems (aeroponic, hydroponic and peatmoss slab systems). A model was developed to predict the nutrients consumption by basil plants. Shoot and root height, fresh and dry mass of whole plant, nutrients uptake, and oil content were studied during the growth period (after 4 and 7 weeks from transplanting). The results indicated that the shoot lengths of basil plants were 62.00 ± 2.65, 57.83 ± 7.42 and 48.77 ± 2.89 cm after 4 weeks and 71.67 ± 2.89, 65.67 ± 1.15 and 62.33 ± 2.31cm after 7 weeks from transplanting for aeroponic, hydroponic and peatmoss slabs, respectively. The highest value of root height of basil plants was 37.67 ± 6.66 cm for aeroponic system. The dry mass of shoot of basil plants ranged from 28.48 ± 0.91 to 44.77 ± 0.97 and 72.98 ± 0.83 to 117.93 ± 1.40 g plant-1 after 4 and 7weeks from transplanting, respectively. The highest values of the N, P, K, Ca and Mg uptakes were 262.50 ± 6.84, 74.34 ± 2.90, 195.13 ± 4.09, 132.41 ± 1.54 and 41.81 ± 0.83 mg plant-1 and 753.99 ± 5.65, 224.88 ± 3.05, 449.75 ± 4.59, 529.12 ± 6.63 and 112.44 ± 1.67 mg plant-1 after 4 and 7 weeks from transplanting, respectively. The basil oil content ranged from 1.129 ± 0.020 to 2.520 ± 0.021 and 2.664 ± 0.291 to 6.318 ± 0.375 g plant-1 after 4 and 7weeks from transplanting, respectively at the same pervious order. The production costs of basil plant were 2.93, 5.27 and 6.24 EGP kg-1 of plant. The model results were in a reasonable agreement with the experimental ones.