Research Article
Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit
https://doi.org/10.21203/rs.3.rs-1284972/v1
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The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.
No competing interests reported.
Editorial decision: Major revision
02 Mar, 2022
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11 Feb, 2022
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11 Feb, 2022
Editor invited by journal
11 Feb, 2022
Submission checks completed at journal
11 Feb, 2022
First submitted to journal
21 Jan, 2022
You are reading this latest preprint version