The study used structural equation modelling (SEM) techniques to examine the mediation analysis of entrepreneurship development on the economic growth of women entrepreneurs in Nigeria. The study assumes the existence of three null hypotheses; entrepreneurship development does not mediate business performance, psychological, and knowledge of business practice indicators for economic growth. Data were collected from 500 randomly selected women entrepreneurs in Nigeria. Our results suggest that separating household and business income, maintaining a separate business account, stock-keeping, record-keeping among other were the knowledge of business practice indicators; openness to change, desire for self-independent among others were the psychological indicators, and reduced inactivity, increase in the size of the inventory among others were the business performance indicators that stimulate entrepreneurship development. The aforementioned catalyzed higher formalization, increases in capital investment among others as entrepreneurship development indices, which stimulate economic growth of contribution to personal and children school fare, reduction in financial dependence, and increase in affordable health care fee among others. We also established that entrepreneurship development mediates knowledge of business practice to economic growth.