Acknowledgments
We are grateful to Dr. Hidetaka Miyauchi for his valuable suggestions. We thank Ms. Sumie Nakagawa for management of blood specimens. We also thank Ms. Noriko Kitayama and Ms. Maki Yoneyama for support of the patients.
Funding
This study (KURAMA cohort study) is supported by a grant from Daiichi Sankyo Co. Ltd. The funder had no role in the design of the study, the collection or analysis of the data, the writing of the manuscript or the decision to submit the manuscript for publication.
Competing interests
M.H., K.M. (Murata), K.N., and M.T. (Tanaka) are members of a department that is financially supported by Nagahama City, Shiga, Japan, Toyooka City, Hyogo, Japan and five pharmaceutical companies (Tanabe-Mitsubishi, Chugai, UCB Japan, Ayumi and Asahi-Kasei). The KURAMA cohort study is supported by a grant from Daiichi Sankyo Co. Ltd. M.H. receives grants and/or speaker fees from Bristol-Meyers, Eisai, Eli Lilly, and Tanabe Mitsubishi. K.N. received a research grant from Asahi-Kasei Pharma. H.I. receives a research grant and/or speaker fee from Bristol-Myers, Kyocera, and Asahi-Kasei. K.O. has received research grants and/or speaker’s fee from Abbvie, Actelion, Asahikasei Pharma, Astellas, AYUMI, Bristol-Myers Squibb, Chugai, Daiichi-Sankyo, Eisai, Eli Lilly, GSK, Janssen, JB, Mitsubishi Tanabe, Nippon Kayaku, Nippon Shinyaku, Novartis, Sanofi and Takeda. S.M. receives grants and/or speaker fees from Daiichi Sankyo, Asahi-Kasei, Chugai, Ayumi, and Tanabe Mitsubishi. A.M. has received speaking fees and/or research grants from Eli Lilly Japan K.K., Ono Pharmaceutical Co., Pfizer Inc., UCB Japan, AbbVie G.K., Asahi Kasei Pharma and Chugai Pharmaceutical Co. Ltd. H.M., M.K., T.Y., Y.F., K.I., N.I., Y.O., W.Y., K.M.(Murakami), H.A., and N.I. declare no conflicts of interest. The sponsors had no role in the design of the study, the collection or analysis of the data, the writing of the manuscript or the decision to submit the manuscript for publication. The authors, their immediate families, and any research foundations with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article.
Author Contributions
H.M., M.H., and Y.F. are responsible for study conception and design. H.M. and M.K contributed to interpretation of the data, drafted the manuscript, and revised the manuscript. T.Y. contributed to acquisition of the data. M.H. and Y.F contributed to interpretation of the data and revised the manuscript. K.I., N.I., Y.O., M.S., W.Y, R.W., K.M.(Murakami), K.M. (Murata), K.N., M.T., H.I., K.O., S.M., N.I., and A.M. contributed to supervision of the manuscript for intellectual content. All authors have approved the final manuscript for publication and have agreed to be personally accountable for the authors’ contributions.
Availability of data and materials
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
This study was conducted according to the Declaration of Helsinki and were approved by the ethics committee of Kyoto University Graduate School and Faculty of Medicine (Approval number: R0357). In all cases, patient consent was obtained prior to sample and data collection
Consent for publication
Not applicable