1. Tremblay, R., Lee, S. & Rudy, B. GABAergic interneurons in the neocortex: From cellular properties to circuits. Neuron 91, 260-292 (2016).
2. Fishell, G. & Kepecs, A. Interneuron Types as Attractors and Controllers. Annu. Rev. Neurosci. 43, 1-30 (2020).
3. Hu, H., Gan, J. & Jonas, P. Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function. Science 345, 1255263 (2014)
4. Sohal, V.S., Zhang, F., Yizhar, O. & Deisseroth, K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459, 698-702 (2009)
5. Gonzalez-Burgos, G., Cho, R.Y. & Lewis, D.A. Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia. Biol. Psychiatry. 77,1031-1040 (2015).
6. Sauer, J.F., Strüber, M. & Bartos, M. Impaired fast-spiking interneuron function in a genetic mouse model of depression. eLife doi:10.7554/eLife.04979 (2015).
7. Martin, J.Z.D.S. et al. Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome. eLife doi:10.7554/eLife.58731 (2020).
8. Carlén, M. et al. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol. Psychiatry 17, 537-548 (2012).
9. Korotkova, T., Fuchs, E.C., Ponomarenko, A., von Engelhardt, J. & Monyer, H. NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron 68, 557-569 (2010).
10. Lee, E. et al. Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice. Nat Commun. 12(1):5116 (2021).
11. Nakazawa et al Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia. NPJ Schizophrenia 3, 7 (2017).
12. Hansen, KB. et al. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacol Rev. 73(4):298-487 (2021).
13. Paoletti, P., Bellone, C. & Zhou, Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci. 14, 383-400 (2013).
14. Mothet, J-P., Le Bail, M. & Billard, J-M.Time and space profiling of NMDA receptor co-agonist functions. J Neurochem. 135, 210-225 (2015).
15. Johnson, J.W. & Ascher, P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325, 529-531 (1987).
16. Kleckner, N.W. & Dingledine, R. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 241, 835-837 (1988).
17. Mothet, J-P., et al. d-Serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 97, 4926-4931 (2000).
18. Anastasiades, P.G. & Carter, A.G. Circuit organization of the rodent medial prefrontal cortex. Trends Neurosci. 44, 550-563 (2021).
19. Le Merre, P., Ährlund-Richter, S. & Carlén, M.The mouse prefrontal cortex: unity in diversity. Neuron 109, 1925-1944 (2021).
20. Gao, W.J, et al. Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction. Mol Psychiatry. doi: 10.1038/s41380-021-01196-w. (2021)
21. Paus, T. et al. Why do many psychiatric disorders emerge during adolescence? Nature Reviews Neurosci. 9, 947–957 (2008).
22. Akgül, G. & McBain, C.J. Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain. J Physiol. 594, 5471-5490 (2016).
23. Booker, S.A. & Wyllie, D.J.A. NMDA receptor function in inhibitory neurons.. Neuropharmacology 196:108609 (2021).
24. Chittajallu, R., et al. Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. Nat Commun 8,152 (2017).
25. Nevian, T. & Sakmann, B. Spine Ca2+ signaling in spike-timing-dependent plasticity. J. Neurosci 26, 11001-11013 (2006).
26. Pafundo, D.E., et al. Presynaptic effects of N-methyl-D-aspartate receptors enhance parvalbumin cell-mediated inhibition of pyramidal cells in mouse prefrontal cortex. Biol Psychiatry 84, 460-470 (2018).
27. Wang, H.X. & Gao, W.J. Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex. Neuropsychopharmacology 34, 2028-2040 (2009).
28. Atkinson, B.N. et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol. Pharmacol. 60, 1414–1420 (2001)
29. Papouin, T. et al. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 150, 633–646 (2012).
30. Li, Y. et al. Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat Commun. 4, 1760 (2013). https://doi.org/10.1038/ncomms2779.
31. Le Bail, M. et al. Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus. Proc. Natl. Acad.Sci. USA 112, 204–213 (2015).
32. Ferraris D, et al. Synthesis and biological evaluation of D-amino acid oxidase inhibitors. J Med Chem. 51, 3357-3359 (2008).
33. Hashimoto, K. et al. Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. Biol. Psychiatry 65, 1103–1106 (2009).
34. Pollegioni, L. & Sacchi, S. Metabolism of the neuromodulator d-serine.Cell Mol Life Sci. 67, 2387-2404 (2010).
35. Miyoshi, Y., et al. Alteration of intrinsic amounts of d-serine in the mice lacking serine racemase and D-amino acid oxidase.Amino Acids 43,1919-1931 (2012).
36. Verrall L, et al. he neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry 15, 122-37 (2010).
37. Sasabe, J. et al. Activity of D-amino acid oxidase is widespread in the human central nervous system. Front Synaptic Neurosci. Jun 10;6:14 (2014).
38. Wolosker, H., Blackshaw, S. & Snyder, S.H. Serine racemase: a glial enzyme synthesizing d-serine to regulate glutamate N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci USA 96, 13409-13414 (1999).
39. Raboni, S, et al. The Energy Landscape of Human Serine Racemase. Front Mol Biosci. Jan 9;5:112..(2019).
40. Coyle, JT & Balu, DT. The Role of Serine Racemase in the Pathophysiology of Brain Disorders. Adv Pharmacol. 82:35-56 (2018)
41. Basu, A.C., et al. Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry 14, 719-727 (2009).
42. Balu, D.T. et al. Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. Proc. Natl. Acad.Sci. USA 110, 2400–2409 (2013).
43. Sullivan, S.J., et al. Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells. J Physiol. 589, 5997-6006 (2011).
44. Santini, MA. et al. D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI. Behav Brain Res. 2014 259:242-6 (2014).
45. Labrie, V. et al. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 18(17):3227-43 (2009).
46. Dallerac, G. et al. Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist D-serine. Proc Natl Acad Sci USA 118, e2023750118 (2021).
47. Liu, L., et al. Cell type-differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction. Sci Adv 6(30):eaay4073 (2020).
48. Kawaguchi, Y., et al. Control of excitatory hierarchical circuits by parvalbumin-FS basket cells in layer 5 of the frontal cortex: insights for cortical oscillations. J Neurophysiol. 121, 2222-2236 (2019)
49. Ter Wal, M. & Tiesinga, P.H.E. Comprehensive characterization of oscillatory signatures in a model circuit with PV- and SOM-expressing interneurons. Biol Cybern. 115, 487-517 (2021).
50. Wang, X.J. Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. J Neurosci. 19, 9587-9603 (1999).
51. Chen C, Blitz DM, Regehr WG. Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse. Neuron 33, 779-788 (2002).
52. Nissen, W., et al. Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor. J Neurosci. 30,1337-1347 (2010).
53. Le Roux, N., et al. Input-specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons. J Physiol. 591, 1809-1822 (2013).
54. Szegedi, V., et al. Plasticity in single axon glutamatergic connection to GABAergic interneurons regulates complex events in the human neocortex. PLoS Biol. 14, e2000237 (2016).
55. Lau, P.Y., et al. Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo. Brain Struct Funct. 222, 1809-1827 (2017).
56. He, X. et al. Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons. Neuron 109, 1013-1028.e9 (2021).
57. Capogna, M. et al. The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles. Eur J Neurosci. 54, 6882-6901 (2021).
58. Aguilar, DD. et al. Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction. Sci Rep. 11, 9031.(2021).
59. Balla, A. et al. Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice. Biomark Neuropsychiatry. Jun;2:100019 (2020).
60. Ploux, E. et al. Serine racemase deletion affects the excitatory/inhibitory balance of the hippocampal CA1 network. Int J Mol Sci. 21, 9447. (2020). https://doi.org/10.3390/ijms21249447
61. Jami, S.A. et al. Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction. J Neurophysiol. 126, 11-27 (2021).
62. Miyamae, T., et al. Distinct Physiological Maturation of parvalbumin-positive neuron subtypes in mouse prefrontal cortex. J. Neurosci. 37, 4883-4902 (2017)
63. Henneberger, C. et al. Long-term potentiation depends on release of D-serine from astrocytes. Nature 463,232-236 (2010).
64. Fossat, P. et al. Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex. Cereb Cortex 22, 595-606 (2012).
65. Rosenberg, D. et al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 33, 3533-44 (2013).,
66. Curcio, L. et al. Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity. Brain 136, 1216-30 (2013).
67. Wong, J.M. et al. Postsynaptic Serine Racemase Regulates NMDA Receptor Function.. J Neurosci. 40, 9564-9575 (2020).
68. Li, Y. et al. Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns. J Neurophysiol. 102, 578-589 (2009).
69. Yao, L. et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 9, 4000 (2018).
70. Semyanov, A & Verkhratsky, A. Astrocytic processes: from tripartite synapses to the active milieu. Trends Neurosci. 44, 781-792 (2021).
71. Refaeli, R et al. Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons. Glia 69, 2378-2390 (2021).
72. Pei, J.C. et al. Directly and indirectly targeting the glycine modulatory site to modulate NMDA receptor function to address unmet medical needs of patients with schizophrenia. Front Psychiatry 12, 742058 (2021).
73. Kaiser, T. et al. Transgenic labeling of parvalbumin-expressing neurons with tdTomato. Neuroscience 321, 236-245 (2016).
74. Grover, LM. Evidence for postsynaptic induction and expression of NMDA receptor independent LTP. J Neurophysiol. 79, 1167-1182 (1998).