Article
Metabolic engineering for provitamin D3 biosynthesis in tomato
https://doi.org/10.21203/rs.3.rs-1403571/v1
This work is licensed under a CC BY 4.0 License
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Providing adequate vitamin D3 for the human diet is a long-standing goal of crop breeding because most plants have relatively low levels of this nutrient naturally. Using CRISPR-Cas9 editing of the tomato genome, we increased provitamin D3 levels in tomato fruits to up to 1 mg per 100 grams dry weight. Use of this provitamin D3 tomato could ameliorate widespread vitamin D deficiencies around the world.
CRISPR-Cas9
Non-GMO
Vegetarian
Vitamin D deficiency
COVID-19
Yes there is potential Competing Interest.
S.Choe is a founder of the two biotech companies, G+FLAS Life Sciences, Inc. and Naturegenic Inc. S.Choi, Ji.K., and Je.K. are employees of G+FLAS Life Sciences. J.P. is an employee of Naturegenic Inc. Authors are inventors on a patent application covering the genome editing method for plant-based vitamin D3 production described in this manuscript.
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