Acknowledgements
We acknowledge the contribution of all staff who participated in the present study as well as the study participants who shared their time with us.
Authors’ contributions
Concept and design of this study: Dr. Ping Li and Xiping Xu; Manuscript composition: Dr. Huan Hu, and Ping Li; Data acquisition and collation: Lishun Liu; Statistical analysis: Huan Hu, Ping Wang and Ziyi Zhou; Reviewed and revised the manuscript: Ping Li, Xiao Huang, Huihui, Bao, and Xiping Xu. The other authors coordinated this analysis. All authors read and approved the final manuscript.
Funding
The study was supported by funding from the following: the National Key Research and Development Program [2016YFE0205400, 2018ZX09739010, 2018ZX09301034003], the Science and Technology Planning Project of Guangzhou, China [201707020010]; the Science, Technology and Innovation Committee of Shenzhen [GJHS20170314114526143, JSGG20180703155802047]; the Economic, Trade and Information Commission of Shenzhen Municipality [20170505161556110, 20170505160926390]; the National Natural Science Foundation of China [81960074, 81860058, 81500233, 81560079]; the Jiangxi Outstanding Person Foundation [20192BCBL23024], the Major Projects of the Science and Technology Department, Jiangxi [20171BAB205008, 20152ACB20022], the Funding Scheme for Academic and Technical Leaders of Major Disciplines, Jiangxi [20172BCB22027], and Special Funds for Guiding Local Scientific and Technological Development by the Central Government of China (S2019CXSFG0016).
Conflict of Interest Disclosures:
Dr. Xiping Xu reports grants from the National Key Research and Development Program [2016YFE0205400, 2018ZX09739010, 2018ZX09301034003), the Science and Technology Planning Project of Guangzhou, China (201707020010), the Science, Technology and Innovation Committee of Shenzhen [GJHS20170314114526143, JSGG20180703155802047), and the Economic, Trade and Information Commission of Shenzhen Municipality [20170505161556110, 20170505160926390].
Dr. Xiao Huang reports grants from the National Natural Science Foundation of China [81960074, 81500233], the Jiangxi Outstanding Person Foundation [20192BCBL23024], and Major projects of the Science and Technology Department, Jiangxi [20171BAB205008].
Dr. Ping Li reports grants from the National Natural Science Foundation of China [81560079, 81860058], Major Projects of the Science and Technology Department, Jiangxi, [20152ACB20022], Funding Scheme for Academic and Technical Leaders of Major Disciplines, Jiangxi [20172BCB22027], and Special Funds for Guiding Local Scientific and Technological Development by the Central Government of China (S2019CXSFG0016). No other disclosures were reported.
Availability of data and materials
All data are available from the corresponding author upon request.
Ethics approval and consent to participate
The protocol of the present study was approved by the the Ethics Committee of the Institute of Biomedicine, Anhui Medical University, Hefei, China. All participants signed an approved written consent form.
Competing interests
The authors declare that they have no competing interests.
Author details
1Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi Province, China. 2Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang, No. 1 Minde Road, Nanchang, Jiangxi Province, China. 3People's Hospital of Rongcheng, No. 298 Chengshan Avenue, Rongcheng, Shandong Province, China. 4Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua East Road, Beijing, China. 5Institute of Biomedicine, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui Province, China. 6Shenzhen Evergreen Medical Institute, No. 16 Gaoxin Middle 1 Road, Shenzhen, China. 7School of Public Health (Shenzhen), Sun Yat-Sen University, No. 135 Xingang West Road, Guangzhou, Guangdong Province, China. 8Health and Family Planning Commission, No. 688 Qingshan East Road, Rongcheng, Shandong Province, China. 9 Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Beijing, China. 10Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 3400 N. Charles Street, Baltimore, MD, 21205, USA