Background
Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying and change in stool consistency. We compared the effectiveness of dietary treatment of three different diet plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome.
Methods
73 female patients diagnosed with mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with dietitian. Patients from group 3 (G3-K) received nutrition advice from a gastroenterologist.
Results
Significant differences in reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group, while in the G1-FM group, some of the IBS symptoms significantly improved. In group G3-K no significant improvement was seen.
Conclusion
Based on the results of this open study it was found that the different dietary intervention in the treatment of patients with IBS-M was unlikely effective. The G2-IP IgG based elimination-rotation-diet demonstrating a significant overall superior result compared to the others.
Trial registration
The clinical trial was retrospective registered at ClinicalTrials.gov, March 12, 2020, ClinicalTrials.gov ID: NCT04307368.