1 Hoste EAJ, Kellum JA, Selby NM, Zarbock A, Palevsky PM, Bagshaw SM, Goldstein SL, Cerdá J, Chawla LS: Global epidemiology and outcomes of acute kidney injury. Nat Rev Nephrol 2018;14(10):607-25. DOI: 10.1038/s41581-018-0052-0.
2 Bonventre JV, Weinberg JM: Recent advances in the pathophysiology of ischemic acute renal failure. J Am Soc Nephrol 2003;14(8):2199-210. DOI: 10.1097/01.asn.0000079785.13922.f6.
3 Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011;121(11):4210-21. DOI: 10.1172/jci45161.
4 Chawla LS, Eggers PW, Star RA, Kimmel PL: Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 2014;371(1):58-66. DOI: 10.1056/NEJMra1214243.
5 Smith MJ, Simmons KM, Cambier JC: B cells in type 1 diabetes mellitus and diabetic kidney disease. Nat Rev Nephrol 2017;13(11):712-20. DOI: 10.1038/nrneph.2017.138.
6 Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME: Diabetic kidney disease. Nat Rev Dis Primers 2015;1:15018. DOI: 10.1038/nrdp.2015.18.
7 Yu SM, Bonventre JV: Acute Kidney Injury and Progression of Diabetic Kidney Disease. Adv Chronic Kidney Dis 2018;25(2):166-80. DOI: 10.1053/j.ackd.2017.12.005.
8 Hertzberg D, Sartipy U, Holzmann MJ: Type 1 and type 2 diabetes mellitus and risk of acute kidney injury after coronary artery bypass grafting. Am Heart J 2015;170(5):895-902. DOI: 10.1016/j.ahj.2015.08.013.
9 Kim NY, Hong JH, Koh DH, Lee J, Nam HJ, Kim SY: Effect of Diabetes Mellitus on Acute Kidney Injury after Minimally Invasive Partial Nephrectomy: A Case-Matched Retrospective Analysis. J Clin Med 2019;8(4). DOI: 10.3390/jcm8040468.
10 Yang J, Lee JY, Na YJ, Lim SY, Kim MG, Jo SK, Cho W: Risk factors and outcomes of acute renal infarction. Kidney Res Clin Pract 2016;35(2):90-5. DOI: 10.1016/j.krcp.2016.04.001.
11 Venot M, Weis L, Clec'h C, Darmon M, Allaouchiche B, Goldgran-Tolédano D, Garrouste-Orgeas M, Adrie C, Timsit JF, Azoulay E: Acute Kidney Injury in Severe Sepsis and Septic Shock in Patients with and without Diabetes Mellitus: A Multicenter Study. PLoS One 2015;10(5):e0127411. DOI: 10.1371/journal.pone.0127411.
12 Thakar CV, Christianson A, Himmelfarb J, Leonard AC: Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol 2011;6(11):2567-72. DOI: 10.2215/CJN.01120211.
13 Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, Deftereos S, Tousoulis D: The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives. Eur Cardiol 2019;14(1):50-59. DOI: 10.15420/ecr.2018.33.1.
14 Ponce BA, Menendez ME, Oladeji LO, Soldado F: Diabetes as a risk factor for poorer early postoperative outcomes after shoulder arthroplasty. J Shoulder Elbow Surg 2014;23(5):671-8. DOI: 10.1016/j.jse.2014.01.046.
15 Ardeshiri M, Faritus Z, Ojaghi-Haghighi Z, Bakhshandeh H, Kargar F, Aghili R: Impact of metabolic syndrome on mortality and morbidity after coronary artery bypass grafting surgery. Res Cardiovasc Med 2014;3(3):e20270. DOI: 10.5812/cardiovascmed.20270.
16 Muroya Y, He X, Fan L, Wang S, Xu R, Fan F, Roman RJ: Enhanced renal ischemia-reperfusion injury in aging and diabetes. Am J Physiol Renal Physiol 2018;315(6):F1843-F54. DOI: 10.1152/ajprenal.00184.2018.
17 Gong DJ, Wang L, Yang YY, Zhang JJ, Liu XH: Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis. Ren Fail 2019;41(1):750-61. DOI: 10.1080/0886022X.2019.1643737.
18 Shi H, Patschan D, Epstein T, Goligorsky MS, Winaver J: Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury. Am J Physiol Renal Physiol 2007;293(5):F1512-7. DOI: 10.1152/ajprenal.00215.2007.
19 Idris-Khodja N, Ouerd S, Mian MOR, Gornitsky J, Barhoumi T, Paradis P, Schiffrin EL: Endothelin-1 Overexpression Exaggerates Diabetes-Induced Endothelial Dysfunction by Altering Oxidative Stress. Am J Hypertens 2016;29(11):1245-51. DOI: 10.1093/ajh/hpw078.
20 Snelgrove SL, Lo C, Hall P, Lo CY, Alikhan MA, Coates PT, Holdsworth SR, Hickey MJ, Kitching AR: Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury. Transplantation 2017;101(5):1013-24. DOI: 10.1097/TP.0000000000001427.
21 de Ponte MC, Casare FAM, Costa-Pessoa JM, Cardoso VG, Malnic G, Mello-Aires M, Volpini RA, Thieme K, Oliveira-Souza M: The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury. Kidney Blood Press Res 2017;42(6):1277-89. DOI: 10.1159/000485931.
22 Oakley BR, Kirsch DR, Morris NR: A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal Biochem 1980;105(2):361-3. DOI: 10.1016/0003-2697(80)90470-4.
23 de Araújo L, Costa-Pessoa JM, de Ponte MC, Oliveira-Souza M: Sodium Oxalate-Induced Acute Kidney Injury Associated With Glomerular and Tubulointerstitial Damage in Rats. Front Physiol 2020;11:1076. DOI: 10.3389/fphys.2020.01076.
24 Casare FA, Thieme K, Costa-Pessoa JM, Rossoni LV, Couto GK, Fernandes FB, Casarini DE, Oliveira-Souza M: Renovascular remodeling and renal injury after extended angiotensin II infusion. Am J Physiol Renal Physiol 2016:ajprenal.00471.2015. DOI: 10.1152/ajprenal.00471.2015.
25 Yu B, Ma J, Li J, Wang D, Wang Z, Wang S: Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. Nat Commun 2020;11(1):2549. DOI: 10.1038/s41467-020-16312-7.
26 Rodríguez C, Contreras C, Sáenz-Medina J, Muñoz M, Corbacho C, Carballido J, García-Sacristán A, Hernandez M, López M, Rivera L, Prieto D: Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation. Redox Biol 2020;34:101575. DOI: 10.1016/j.redox.2020.101575.
27 Bao C, Yang Z, Cai Q, Li Q, Li H, Shu B: Incremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice. Int J Mol Med 2019;44(5):1677-86. DOI: 10.3892/ijmm.2019.4344.
28 Choi HJ, Jang HJ, Park E, Tingskov SJ, Nørregaard R, Jung HJ, Kwon TH: Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct. Cells 2020;9(5). DOI: 10.3390/cells9051208.
29 Miao S, Lv C, Liu Y, Zhao J, Li T, Wang C, Xu Y, Wang X, Xiao X, Zhang H: Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice. Front Physiol 2020;11:138. DOI: 10.3389/fphys.2020.00138.
30 Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 2009;20(1):223-8. DOI: 10.1681/ASN.2007080837.
31 Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, Suzuki Y, Yahagi N, Nishiyama A, Gunaratnam L, Takano T, Miyazaki T: Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice. Nat Med 2016;22(2):183-93. DOI: 10.1038/nm.4012.
32 Levey AS, Coresh J, Tighiouart H, Greene T, Inker LA: Measured and estimated glomerular filtration rate: current status and future directions. Nat Rev Nephrol 2020;16(1):51-64. DOI: 10.1038/s41581-019-0191-y.
33 Garg P: A Review of Podocyte Biology. Am J Nephrol 2018;47 Suppl 1:3-13. DOI: 10.1159/000481633.
34 Greka A, Mundel P: Cell biology and pathology of podocytes. Annu Rev Physiol 2012;74:299-323. DOI: 10.1146/annurev-physiol-020911-153238.
35 Serafini-Cessi F, Malagolini N, Cavallone D: Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 2003;42(4):658-76. DOI: 10.1016/s0272-6386(03)00829-1.
36 Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, Schaeffer C, Olinger E, Peng J, Santambrogio S, Perrier R, Li S, Bokhove M, Bachi A, Hummler E, Devuyst O, Wu Q, Jovine L, Rampoldi L: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. Elife 2015;4:e08887. DOI: 10.7554/eLife.08887.
37 Fairley JK, Owen JE, Birch DF: Protein composition of urinary casts from healthy subjects and patients with glomerulonephritis. Br Med J (Clin Res Ed) 1983;287(6408):1838-40. DOI: 10.1136/bmj.287.6408.1838.
38 Perazella MA, Coca SG, Kanbay M, Brewster UC, Parikh CR: Diagnostic value of urine microscopy for differential diagnosis of acute kidney injury in hospitalized patients. Clin J Am Soc Nephrol 2008;3(6):1615-9. DOI: 10.2215/CJN.02860608.
39 Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV: KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest 2015;125(4):1620-36. DOI: 10.1172/JCI75417.
40 Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 2002;62(1):237-44. DOI: 10.1046/j.1523-1755.2002.00433.x.
41 Ichimura T, Asseldonk EJ, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV: Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 2008;118(5):1657-68. DOI: 10.1172/JCI34487.
42 Maeshima Y, Kashihara N, Sugiyama H, Makino H, Ota Z: Antisense oligonucleotides to proliferating cell nuclear antigen and Ki-67 inhibit human mesangial cell proliferation. J Am Soc Nephrol 1996;7(10):2219-29.
43 Li F, Guo H, Yang Y, Feng M, Liu B, Ren X, Zhou H: Autophagy modulation in bladder cancer development and treatment (Review). Oncol Rep 2019;42(5):1647-55. DOI: 10.3892/or.2019.7286.
44 Bernard A, Klionsky DJ: Autophagosome formation: tracing the source. Dev Cell 2013;25(2):116-7. DOI: 10.1016/j.devcel.2013.04.004.
45 Kim J, Kundu M, Viollet B, Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011;13(2):132-41. DOI: 10.1038/ncb2152.
46 Bach M, Larance M, James DE, Ramm G: The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J 2011;440(2):283-91. DOI: 10.1042/BJ20101894.
47 Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL: Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013;152(1-2):290-303. DOI: 10.1016/j.cell.2012.12.016.
48 Inoki K, Zhu T, Guan KL: TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115(5):577-90. DOI: 10.1016/s0092-8674(03)00929-2.
49 Döring T, Zeyen L, Bartusch C, Prange R: Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation. J Virol 2018;92(7). DOI: 10.1128/JVI.01513-17.
50 Johansen T, Lamark T: Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011;7(3):279-96.
51 Kaushal GP, Chandrashekar K, Juncos LA, Shah SV: Autophagy Function and Regulation in Kidney Disease. Biomolecules 2020;10(1). DOI: 10.3390/biom10010100.
52 Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine B: Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007;128(5):931-46. DOI: 10.1016/j.cell.2006.12.044.
53 Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS: Interleukin-1. J Am Soc Nephrol 2018;29(6):1690-705. DOI: 10.1681/ASN.2017121283.
54 Lee SB, Kalluri R: Mechanistic connection between inflammation and fibrosis. Kidney Int Suppl 2010(119):S22-6. DOI: 10.1038/ki.2010.418.
55 Meng XM, Nikolic-Paterson DJ, Lan HY: TGF-β: the master regulator of fibrosis. Nat Rev Nephrol 2016;12(6):325-38. DOI: 10.1038/nrneph.2016.48.
56 Rao K B, Malathi N, Narashiman S, Rajan ST: Evaluation of myofibroblasts by expression of alpha smooth muscle actin: a marker in fibrosis, dysplasia and carcinoma. J Clin Diagn Res 2014;8(4):ZC14-7. DOI: 10.7860/JCDR/2014/7820.4231.
57 Naylor RW, Morais MRPT, Lennon R: Complexities of the glomerular basement membrane. Nat Rev Nephrol 2020. DOI: 10.1038/s41581-020-0329-y.