Big data analysis and Artificial Intelligence have received significant attention recently in creating more opportunities in the health sector for aggregating or collecting large-scale data. Today, our genomes and microbiomes can be sequenced i.e., all information exchanged between physicians and patients in Electronic Health Records (EHR) can be collected and traced at least theoretically. Social media and mobile devices today obviously provide many health-related data regarding activity, diets, social contacts, and so on. However, it is increasingly difficult to use this information to answer health questions and, in particular, because the data comes from various domains and lives in different infrastructures and of course it also is very variable quality. The massive collection and aggregation of personal data come with a number of ethical policy, methodological, technological challenges. It should be acknowledged that large-scale clinical evidence remains to confirm the promise of Big Data and Artificial Intelligence (AI) in health care. This paper explores the complexities of big data & artificial intelligence in healthcare as well as the benefits and prospects.