In this study, we introduce nano-baits that are formed based on the binding of glucose in a silicon nanoparticle. Sila-dodecahedrane has been selected among of four other famous nanostructures, due to its high stability, biocompatibility and its ability to engineer electronic features. Because of the glucose attached to nano-baits, they are attractive to cancer cells that consume high glucose. In this research, two nano-baits have been modeled with the chemical formulas of Si20H19C6H11O6 and Si20H13(C6H11O6)7. Their optimal structures are obtained using density functional theory (DFT). For this, we use the B3LYP hybrid functional and 6-31+g(d,p) basis set. Vibration frequency calculations show that the glucose binding of a sila-dodecahedrane has a stable bond. These nano-baits with photoluminescence determine the location of cancer cells. By adjusting the number of glucoses attached to these nano-baits, the energy required for their excitation and light response can be adjusted. These nano-baits are a viable alternative to radioactive materials for locating cancer cells.