The clinicopathological effects of E. coli infected Psittaculakrameri (ring necked parrots) supplemented with N. sativa seeds in feed were evaluated. Faecal samples from “psittacine” species parrots were collected and E. coli was isolated for cultural, morphological, biochemical and in-vitro studies. A total of 27 parrots were selected and divided into 03 groups (A= control, B= no treatment and C= treatment+ infection) having 09 parrots in each and were fed with N. Sativa seeds @100mg/kg from 3rd day. The parrots of group B and C were challenged with 0.1ml pathogenic E. coli @106CFU/ml/bird subcutaneously on day 9th. Clinical signs, mortality and morbidity rates were observed during the trial. For haematology, histopathology and CRP in sera, three birds were slaughtered weekly from each group. Significant decreased in feed consumption, haematological values like red blood cells, haemoglobin and pack cell volume while significant increase in clinical signs, morbidity, mortality, liver, heart, kidneys weights and white blood cell were recorded in group B. C-Reactive protein values was significantly decreased in group C as compared to group B while degenerative changes were seen in liver, heart and kidneys of group B.