Soil structure interaction (SSI) may considerably affect the seismic vulnerability of subsea high pressure/high temperature (HP/HT) pipelines. Numerical simulations are herein proposed to study the effects of soil deformability on failure of an unburied pipeline with D/t = 20, laid on the seabed and resting on a sleeper. OpenSees is used to assess an earthquake scenario imposed on a laterally buckled pipeline by considering the effects of non-linear soil behaviour on the mechanisms that induce damage on the soil-pipeline system. Uncertainties in the case study were considered by applying a probabilistic-based approach and by developing analytical fragility curves that allow estimation of the probability of exceedance of the selected failure criteria.