Aims: We aimed to evaluate risk factors influencing adverse short-term outcomes in contrast-induced acute kidney injury (CI-AKI) patients after coronary angiography (CA) or percutaneous coronary intervention (PCI).
Materials and methods: We retrospectively collected 64 consecutive CI-AKI patients after CA/PCI procedure from January 2014 to November 2019. The clinical outcomes were in-hospital mortality and persistent renal dysfunction (RD). Univariable and multivariable analyses were used to identify the risk factors for in-hospital mortality and persistent RD.
Results: The incidence of in-hospital mortality was 7.8% in CI-AKI patients. After adjusting potential confounders, cardiogenic shock (OR=40.5, 95% CI, 4.147–395.494, P=0.001) was the independent risk factor for in-hospital mortality. Persistent RD occurred in 35 (59%) of survival patients. After adjusting potential confounders, eGFR (OR=3.553, 95% CI, 1.497–25.416, P=0.027), duration of procedure (OR=1.037, 95% CI, 1.002–1.073, P=0.038) and contrast media category (OR=7.189, 95% CI, 1.202–42.982, P=0.031) were independent risk factors for persistent RD.
Conclusion: In-hospital mortality of CI-AKI patients was associated with severe systemic hemodynamic alteration. Patients with existing renal impairment before CA/PCI were more likely to develop persistent RD, while reducing CA/PCI procedure time and use of isotonic contrast media (IOCM) might help decreasing the risk.