Compound parabolic concentrator (CPC) collector has been used in present study due to its proper performance and lower operating costs per unit of heat increase compared to other tracker concentrators. This type of collector has been given more attention in industrial and domestic applications in the temperature range of 60°C to 300°C. Also, in order to increase the thermal efficiency (TE), nanofluid (NF) containing SiO2 nanoparticles (NPs) in ethylene glycol (EG)-Water hybrid base fluid (10-90 Vol.%) has been used in three different volumetric fractions. The innovations of the present study include the utilization of mentioned NFs for the first time in this collector, which has good stability and cost-effective compared to other NPs. In addition, the experimental measurement of thermal and hydraulic properties of NFs could be considered as one of the new aspects of the present study. The experiments have been performed using three volumetric fractions of 0.5%, 1% and 1.5% under extensive solar radiation. Thermal performance (TP) at various volumetric flow rates (VFRs) in steady-state conditions has been investigated according to ASHRAE standard 93-2010 (RA2014). According to the experimental data, the TE of the collector was improved by 5 to 11.6%, when the NF was utilized. The maximum enhancements of the average Nusselt number of the NF versus the base fluid at the VFR of 1 Lit/min and the volumetric fraction of 1.5% are equal to 7.3%. Besides, NF increased the pressure drop and consequently the pumping power raised by a maximum of 3.58%. Finally, to consider Simultaneous both the impacts of heat transfer and pressure drop, performance evaluation criteria (PEC) and overall efficiency for NF have been analyzed. The results represented that in all volumetric fractions, the values of performance evaluation criteria and overall efficiency enhanced compared to the base fluid. This research provides researchers and engineers with useful information in order to better understand the thermal and hydraulic parameters of the parabolic compound concentrator in the presence of NF to improve its TP. The results also highlight the potential of using SiO2 NPs to improve the TE of solar collectors despite their low thermal conductivity compared to other conventional NPs.