Livestock contributes to 14.5 percent of global greenhouse gas emissions, with ruminants being the largest contributor through enteric methane emissions. Although several mitigation strategies are available to reduce livestock methane, no consensus exists on which methods are the most effective. Here, the mitigation impact of the most pragmatic strategies to reduce enteric methane has been projected to 2050, using cattle emissions as a model. The projection shows that supplementing ruminant feed with anti-methanogenic seaweed and converting grassland into silvopasture offer the greatest potential to reduce emissions. With a synergic combination of strategies, the livestock sector in Europe and most of Asia can reach carbon neutrality by 2035 and 2038, respectively. However, global cattle CO2-eq emissions will be reduced by no more than 34 percent by 2050, remaining far above the carbon neutrality target. Mitigation strategies alone are insufficient to lower emissions, and reducing the demand for ruminant products is also necessary – particularly in Africa and Western Asia.