Batistatou A, Stefanou D, Goussia A, Arkoumani E, Papavassiliou AG, Agnantis NJ (2004) Estrogen receptor beta (ERbeta) is expressed in brain astrocytic tumors and declines with dedifferentiation of the neoplasm. J Cancer Res Clin Oncol 130 (7):405-410. doi:10.1007/s00432-004-0548-9
Buschauer A, Friese-Kimmel A, Baumann G, Schunack W (1992) Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups. European Journal of Medicinal Chemistry 27 (4):321-330. doi:10.1016/0223-5234(92)90145-q
Buu-HoÏ NP, Xuong ND, Rips R (1957) New Fluorine-containing Aromatics as Potential Carcinostats. The Journal of Organic Chemistry 22 (2):193-197. doi:10.1021/jo01353a028
Csuros Z, Deak G, Szolnoki J (1962) Condensation of benzaldehyde and benzyl cyanide catalyzed by ion exchange resins. Preparation of some new ring-substituted α-phenylcinnamonitrile derivatives. . Acta Chimica Academiae Scientiarum Hungaricae 33 (1):341-342
Dann O, Bergen G, Demant E, Volz G (1971) Trypanocide Diamidine des 2-Phenyl-benzofurans, 2-Phenyl-indens und 2-Phenyl-indols. Justus Liebigs Annalen der Chemie 749 (1):68-89. doi:10.1002/jlac.19717490110
Dromard C, Guillon H, Rigau V, Ripoll C, Sabourin JC, Perrin FE, Scamps F, Bozza S, Sabatier P, Lonjon N, Duffau H, Vachiery-Lahaye F, Prieto M, Tran Van Ba C, Deleyrolle L, Boularan A, Langley K, Gaviria M, Privat A, Hugnot JP, Bauchet L (2008) Adult human spinal cord harbors neural precursor cells that generate neurons and glial cells in vitro. Journal of neuroscience research 86 (9):1916-1926. doi:10.1002/jnr.21646
Feldman RD, Limbird LE (2017) GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer. Annu Rev Pharmacol Toxicol 57:567-584. doi:10.1146/annurev-pharmtox-010716-104651
Guichet PO, Bieche I, Teigell M, Serguera C, Rothhut B, Rigau V, Scamps F, Ripoll C, Vacher S, Taviaux S, Chevassus H, Duffau H, Mallet J, Susini A, Joubert D, Bauchet L, Hugnot JP (2013) Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors. Glia 61 (2):225-239. doi:10.1002/glia.22429
Hull EE, Montgomery MR, Leyva KJ (2016) HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases. BioMed research international 2016:8797206. doi:10.1155/2016/8797206
Hsieh CH, Wu CP, Lee HT, Liang JA, Yu CY, Lin YJ (2012) NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme. Free radical biology & medicine 53 (4):649-658. doi:10.1016/j.freeradbiomed.2012.06.009
Jana A, Reddy CB, Maji B (2018) Manganese Catalyzed α-Alkylation of Nitriles with Primary Alcohols. ACS Catalysis 8 (10):9226-9231. doi:10.1021/acscatal.8b02998
Kim RK, Kim MJ, Yoon CH, Lim EJ, Yoo KC, Lee GH, Kim YH, Kim H, Jin YB, Lee YJ, Cho CG, Oh YS, Gye MC, Suh Y, Lee SJ (2012) A new 2-pyrone derivative, 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one, suppresses stemness in glioma stem-like cells. Molecular pharmacology 82 (3):400-407. doi:10.1124/mol.112.078402
Lan YL, Zou S, Wang X, Lou JC, Xing JS, Yu M, Zhang B (2017) Update on the therapeutic significance of estrogen receptor beta in malignant gliomas. Oncotarget 8 (46):81686-81696. doi:10.18632/oncotarget.20970
Lee DH, Ryu HW, Won HR, Kwon SH (2017) Advances in epigenetic glioblastoma therapy. Oncotarget 8 (11):18577-18589. doi:10.18632/oncotarget.14612
Li S, Liu X, Chen X, Zhang L, Wang X (2015) Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling. Tumour Biol 36 (12):9661-9665. doi:10.1007/s13277-015-3747-x
Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin D, Black KL, Yu JS (2006) Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Molecular cancer 5:67. doi:10.1186/1476-4598-5-67
Liu J, Sareddy GR, Zhou M, Viswanadhapalli S, Li X, Lai Z, Tekmal RR, Brenner A, Vadlamudi RK (2018) Differential Effects of Estrogen Receptor beta Isoforms on Glioblastoma Progression. Cancer Res 78 (12):3176-3189. doi:10.1158/0008-5472.CAN-17-3470
Liu L, Zhang Y, Wang Y (2005) Phosphine-free palladium acetate catalyzed Suzuki reaction in water. The Journal of organic chemistry 70 (15):6122-6125. doi:10.1021/jo050724z
Lv D, Hu Z, Lu L, Lu H, Xu X (2017) Three-dimensional cell culture: A powerful tool in tumor research and drug discovery. Oncology letters 14 (6):6999-7010. doi:10.3892/ol.2017.7134
Macias Perez ME, Hernandez Rodriguez M, Cabrera Perez LC, Fragoso-Vazquez MJ, Correa-Basurto J, Padilla M, II, Mendez Luna D, Mera Jimenez E, Flores Sandoval C, Tamay Cach F, Rosales-Hernandez MC (2017) Aromatic Regions Govern the Recognition of NADPH Oxidase Inhibitors as Diapocynin and its Analogues. Archiv der Pharmazie 350 (10). doi:10.1002/ardp.201700041
Martinez-Archundia M, Garcia-Vazquez JB, Colin-Astudillo B, Bello M, Prestegui-Martel B, Chavez-Blanco A, Duenas-Gonzalez A, Fragoso-Vazquez MJ, Mendieta-Wejebe J, Abarca-Rojano E, Ordaz-Rosado D, Garcia-Becerra R, Castillo-Bautista D, Correa Basurto J (2018) Computational Study of the Binding Modes of Diverse DPN Analogues on Estrogen Receptors (ER) and the Biological Evaluation of a New Potential Antiestrogenic Ligand. Anticancer Agents Med Chem 18 (11):1508-1520. doi:10.2174/1871520618666171129152953
Martinez-Munoz A, Prestegui-Martel B, Mendez-Luna D, Fragoso-Vazquez MJ, Garcia-Sanchez JR, Bello M, Martinez-Archundia M, Chavez-Blanco A, Duenas-Gonzalez A, Mendoza-Lujambio I, Trujillo-Ferrara J, Correa-Basurto J (2018) Selection of a GPER1 Ligand via Ligand-based Virtual Screening Coupled to Molecular Dynamics Simulations and Its Anti-proliferative Effects on Breast Cancer Cells. Anti-cancer agents in medicinal chemistry 18 (11):1629-1638. doi:10.2174/1871520618666180510121431
Meitzler JL, Antony S, Wu Y, Juhasz A, Liu H, Jiang G, Lu J, Roy K, Doroshow JH (2014) NADPH oxidases: a perspective on reactive oxygen species production in tumor biology. Antioxidants & redox signaling 20 (17):2873-2889. doi:10.1089/ars.2013.5603
Mendéz-Luna D (2019) Rational in silico design, chemical synthesis and in vitro evaluation of new ligands targeting the GPER1 / GPR30 receptor with possible anti-cancer activity. Insituto Politécnico Nacional, Mexico
Méndez-Luna D, Morelos-Garnica LA, García-Vázquez JB, Bello M, Padilla-Martínez II, Fragoso-Vázquez MJ, Dueñas González A, De Pedro N, Gómez-Vidal JA, Mendoza-Figueroa HL, Correa-Basurto J. Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells. Pharmaceuticals (Basel). 2021 Jan 10;14(1):49. doi: 10.3390/ph14010049.
Miyaura N, Yamada K, Suzuki A (1979) A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides. Tetrahedron Letters 20 (36):3437-3440. doi:10.1016/s0040-4039(01)95429-2
Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1-2):55-63. doi:10.1016/0022-1759(83)90303-4
Munoz AM, Fragoso-Vazquez MJ, Martel BP, Chavez-Blanco A, Duenas-Gonzalez A, Garcia-Sanchez JR, Bello M, Romero-Castro A, Correa-Basurto J (2020) Targeting Breast Cancer Cells with G4 PAMAM Dendrimers and Valproic Acid Derivative Complexes. Anticancer Agents Med Chem. doi:10.2174/1871520620666200423073812
Munson J, Bonner M, Fried L, Hofmekler J, Arbiser J, Bellamkonda R (2013) Identifying new small molecule anti-invasive compounds for glioma treatment. Cell cycle 12 (14):2200-2209. doi:10.4161/cc.25334
Nakada M, Kita D, Watanabe T, Hayashi Y, Teng L, Pyko IV, Hamada J (2011) Aberrant signaling pathways in glioma. Cancers 3 (3):3242-3278. doi:10.3390/cancers3033242
Nayernia Z, Jaquet V, Krause KH (2014) New insights on NOX enzymes in the central nervous system. Antioxidants & redox signaling 20 (17):2815-2837. doi:10.1089/ars.2013.5703
Rajak H, Singh A, Raghuwanshi K, Kumar R, Dewangan PK, Veerasamy R, Sharma PC, Dixit A, Mishra P (2013) A Structural Insight into Hydroxamic Acid Based Histone Deacetylase Inhibitors for the Presence of Anticancer Activity. Current Medicinal Chemistry 21 (23):2642-2664. doi:10.2174/09298673113209990191
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille J, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot JP, Duffau H, Bauchet L, Cornu D, Bakalara N (2019) A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-beta1 expression. Scientific reports 9 (1):14612. doi:10.1038/s41598-019-51108-w
Santos-Barriopedro I, Li Y, Bahl S, Seto E (2019) HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Genes Cancer 10 (5-6):119-133. doi:10.18632/genesandcancer.197
Sareddy GR, Li X, Liu J, Viswanadhapalli S, Garcia L, Gruslova A, Cavazos D, Garcia M, Strom AM, Gustafsson JA, Tekmal RR, Brenner A, Vadlamudi RK (2016) Selective Estrogen Receptor beta Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep 6:24185. doi:10.1038/srep24185
Shan F, Close DA, Camarco DP, Johnston PA (2018) High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer. Assay and drug development technologies 16 (1):27-50. doi:10.1089/adt.2017.812
Shea A, Harish V, Afzal Z, Chijioke J, Kedir H, Dusmatova S, Roy A, Ramalinga M, Harris B, Blancato J, Verma M, Kumar D (2016) MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics. Cancer medicine 5 (8):1917-1946. doi:10.1002/cam4.775
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB (2004) Identification of human brain tumour initiating cells. Nature 432 (7015):396-401. doi:10.1038/nature03128
Sixto-Lopez Y (2013) Computational design, synthesis and biological evaluation of bifunctional histone deacetylase 8 and 6 inhibitors with double action at the catalytic and hydrophobic site. Instituto Politécnico Nacional,
Sixto-Lopez Y, Gómez-Vidal JA, de Pedro N, Bello M, Rosales-Hernandez MC, Correa-Basurto J (2020) Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines. Scientific reports:18. doi:https://doi.org/10.1038/s41598-020-67112-4
Vaccaro W, Amore C, Berger J, Burrier R, Clader J, Davis H, Domalski M, Fevig T, Salisbury B, Sher R (1996) Inhibitors of acyl CoA:cholesterol acyltransferase. Journal of medicinal chemistry 39 (8):1704-1719. doi:10.1021/jm950833d
Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P, Maggi A (2003) Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proceedings of the National Academy of Sciences of the United States of America 100 (16):9614-9619. doi:10.1073/pnas.1531957100
Verjans ET, Doijen J, Luyten W, Landuyt B, Schoofs L (2018) Three-dimensional cell culture models for anticancer drug screening: Worth the effort? Journal of cellular physiology 233 (4):2993-3003. doi:10.1002/jcp.26052
Wan S, Jiang J, Zheng C, Wang N, Zhai X, Fei X, Wu R, Jiang X (2018) Estrogen nuclear receptors affect cell migration by altering sublocalization of AQP2 in glioma cell lines. Cell death discovery 4:49. doi:10.1038/s41420-018-0113-y
Wan S, Jiang J, Zheng C, Wang N, Zhai X, Fei X, Wu R, Jiang X (2018) Estrogen nuclear receptors affect cell migration by altering sublocalization of AQP2 in glioma cell lines. Cell death discovery 4:49. doi:10.1038/s41420-018-0113-y
Wang D (2009) Computational Studies on the Histone Deacetylases and the Design of Selective Histone Deacetylase Inhibitors. Current Topics in Medicinal Chemistry 9 (3):241-256. doi:10.2174/156802609788085287
Was H, Krol SK, Rotili D, Mai A, Wojtas B, Kaminska B, Maleszewska M (2019) Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells. Clin Epigenetics 11 (1):11. doi:10.1186/s13148-018-0598-5
Yang CC, Hsiao LD, Tseng HC, Kuo CM, Yang CM (2020) Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-kappaB Activation in Rat Brain Astrocytes Challenged with LPS. Journal of inflammation research 13:325-341. doi:10.2147/JIR.S252659
Yelton CJ, Ray SK (2018) Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma. Neuroimmunology and neuroinflammation 5. doi:10.20517/2347-8659.2018.58
Zacarias-Lara OJ, Mendez-Luna D, Martinez-Ruiz G, Garcia-Sanchez JR, Fragoso-Vazquez MJ, Bello M, Becerra-Martinez E, Garcia-Vazquez JB, Correa-Basurto J (2018) Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting The GPER. Anti-cancer agents in medicinal chemistry. doi:10.2174/1871520618666181119094144
Zacarias-Lara OJ, Mendez-Luna D, Martinez-Ruiz G, Garcia-Sanchez JR, Fragoso-Vazquez MJ, Bello M, Becerra-Martinez E, Garcia-Vazquez JB, Correa-Basurto J (2019) Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting the GPER. Anticancer Agents Med Chem 19 (6):760-771. doi:10.2174/1871520618666181119094144
Zhou M, Sareddy GR, Li M, Liu J, Luo Y, Venkata PP, Viswanadhapalli S, Tekmal RR, Brenner A, Vadlamudi RK (2019) Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways. Sci Rep 9 (1):6124. doi:10.1038/s41598-019-42313-8