We provide a rudimentary insight into the influence of heattransfer on the transport characteristics of a second-grade dusty fluid flownin a flexible tube with walls subjected to the peristaltic motion. Both dust particles and fluid movements were modeled using the coupled differential equations. The derived equations were solved analytically via the standard perturbation method to determine the fluid temperature, streamline patternand velocity of the dust particles as well as fluid. The values in the increase of pressure and frictional forces were calculated numerically using DSolver of the Mathematica software. In addition, the trapping mechanisms were ascertainedby computing the streamlines and various physical parameters. The achievedtransport properties were shown be significantly determined by the parameterslike Reynolds, Prendental, Grashof, wave number as well as nature of the heatsource and sink. The obtained results were validated with the state-of-the-artliterature reports. It was claimed that our systematic approach may constitute a basis for accurately examining the impact of heat transfer on the peristaltic transport of a complex fluid through narrow tubes, useful for diverse medicalapplications such as the gastric fluid flow through the small intestine during endoscopy.