Dengue fever is one of the most common insect-borne diseases in the world, and epidemics mostly occur in tropical and subtropical regions. In the past, the grey multi-attribute decision-making method has been combined with the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method to predict which areas in southern Tainan may easily trigger dengue epidemics. As many studies have shown that the extent of human communication and active government is crucial in dengue prevention, this study aims to propose dengue prevention and control methods before and after the occurrence of dengue cases. This study found that, when dengue fever cases begin to appear, the relevant county and city government departments must hire vector control companies to carry out regional indoor and outdoor spraying. Before the emergence of dengue cases, the green and sustainable-oriented remediation strategies, as promoted by the Environmental Protection Administration (EPA), can be adopted. Remediation of soil and groundwater pollution sites can reduce the source of vector mosquitoes, in order that the green environment can achieve sustainable development.