Consent for Publication The patient’s parents provided written informed consent for research-related analyses and for publication of all elements included in this manuscript, including videos.
Ethics approval and consent to participate This work was overseen at all times by representatives of the Phoenix Children’s IRB #2. Portions of the work considered research as determined by am IRB representative were performed as specified in protocol #15-080.
Availability of Data and Materials Raw data, relevant code, and additional details are available from the corresponding author upon reasonable request.
Funding Portions of this work were supported by NIH 1R01 grant NS106298 to MCK.
Competing Interests The authors declare no relevant conflicts of interest related to the conduct of this work.
Authors Contributions
SAL oversaw the study’s data collection and analysis and co-wrote the manuscript.
SS performed statistical analyses and provide important conceptual input.
SG provided important contributions to study design and conduct.
JH contributed to study conduct, data analysis and interpretation.
NZ provided to data analysis and interpretation and provided conceptual contributions to the manuscript.
GS contributed to study design and data analysis and provided conceptual contributions to the manuscript.
MP contributed to study design and data analysis.
TM contributed to study design and conduct and to interpretation of results.
IM contributed to study design and conduct and to interpretation of results.
RBB contributed to study design and conduct and to interpretation of results.
AAW provided important intellectual contributions to the study’s interpretation.
MCF contributed to study design and data analysis and interpretation.
SK designed and performed the electrophysiology experiments, conducted data analysis and contributed to interpretation.
SJM oversaw electrophysiology experiments, data analysis, contributed to interpretation of findings and provided important intellectual contributions to the manuscript.
BA oversaw study design and implementation, and oversaw the multimodal neurophysiology analysis.
MCK oversaw study design, implementation, and data collection, co-wrote the manuscript, and oversaw the analysis and interpretation of results.
Acknowledgements
We thank the patient’s remarkable parents and the CureGRIN Foundation for their support and guidance during the study period.