1 Treede, R. D. et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70, 1630-1635, doi:10.1212/01.wnl.0000282763.29778.59 (2008).
2 van Hecke, O., Austin, S. K., Khan, R. A., Smith, B. H. & Torrance, N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain 155, 654-662, doi:10.1016/j.pain.2013.11.013 (2014).
3 Baliki, M. N. & Apkarian, A. V. Nociception, Pain, Negative Moods, and Behavior Selection. Neuron 87, 474-491, doi:10.1016/j.neuron.2015.06.005 (2015).
4 Bushnell, M. C., Ceko, M. & Low, L. A. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci 14, 502-511, doi:10.1038/nrn3516 (2013).
5 Dworkin, R. H. et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132, 237-251, doi:10.1016/j.pain.2007.08.033 (2007).
6 Finnerup, N. B. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. The Lancet Neurology 14, 162-173, doi:10.1016/s1474-4422(14)70251-0 (2015).
7 Attal, N. & Bouhassira, D. Pharmacotherapy of neuropathic pain: which drugs, which treatment algorithms? Pain 156 Suppl 1, S104-114, doi:10.1097/01.j.pain.0000460358.01998.15 (2015).
8 Attal, N. et al. Assessing symptom profiles in neuropathic pain clinical trials: can it improve outcome? Eur J Pain 15, 441-443, doi:10.1016/j.ejpain.2011.03.005 (2011).
9 Polydefkis, M. & Raja, S. N. What can we learn from failed neuropathic pain trials? Neurology 70, 250-251, doi:10.1212/01.wnl.0000298088.76718.18 (2008).
10 Majithia, N. et al. Scrambler Therapy for the management of chronic pain. Support Care Cancer 24, 2807-2814, doi:10.1007/s00520-016-3177-3 (2016).
11 Marineo, G. Inside the Scrambler Therapy, a Noninvasive Treatment of Chronic Neuropathic and Cancer Pain: From the Gate Control Theory to the Active Principle of Information. Integr Cancer Ther 18, 1534735419845143, doi:10.1177/1534735419845143 (2019).
12 Marineo, G. Untreatable pain resulting from abdominal cancer: new hope from biophysics? Jop 4, 1-10 (2003).
13 Compagnone, C. & Tagliaferri, F. Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis. Acta Biomed 86, 149-156 (2015).
14 Loprinzi, C. et al. Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial. Support Care Cancer 28, 1183-1197, doi:10.1007/s00520-019-04881-3 (2020).
15 Marineo, G., Iorno, V., Gandini, C., Moschini, V. & Smith, T. J. Scrambler therapy may relieve chronic neuropathic pain more effectively than guideline-based drug management: results of a pilot, randomized, controlled trial. J Pain Symptom Manage 43, 87-95, doi:10.1016/j.jpainsymman.2011.03.015 (2012).
16 Ricci, M. et al. Scrambler therapy: what's new after 15 years? The results from 219 patients treated for chronic pain. Medicine (Baltimore) 98, e13895, doi:10.1097/MD.0000000000013895 (2019).
17 Moon, J. Y. et al. Predictive factors associated with success and failure for Calmare (Scrambler) therapy: a multicenter analysis. Clin J Pain 31, 750-756, doi:10.1097/AJP.0000000000000155 (2015).
18 Ricci, M. et al. Managing chronic pain: results from an open-label study using MC5-A Calmare(R) device. Support Care Cancer 20, 405-412, doi:10.1007/s00520-011-1128-6 (2012).
19 Baron, R., Förster, M. & Binder, A. Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach. The Lancet Neurology 11, 999-1005, doi:10.1016/s1474-4422(12)70189-8 (2012).
20 Baron, R. et al. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 158, 261-272, doi:10.1097/j.pain.0000000000000753 (2017).
21 Bouhassira, D. et al. Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: data from the randomized, double-blind, COMBO-DN study. Pain 155, 2171-2179, doi:10.1016/j.pain.2014.08.020 (2014).
22 Demant, D. T. et al. The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: a randomised, double-blind, placebo-controlled phenotype-stratified study. Pain 155, 2263-2273, doi:10.1016/j.pain.2014.08.014 (2014).
23 Freeman, R., Baron, R., Bouhassira, D., Cabrera, J. & Emir, B. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain 155, 367-376, doi:10.1016/j.pain.2013.10.023 (2014).
24 Soler, D., Morina, D., Kumru, H., Vidal, J. & Navarro, X. Transcranial direct current stimulation and visual illusion effect according to sensory phenotypes in patients with spinal cord injury and neuropathic pain. J Pain, doi:10.1016/j.jpain.2020.06.004 (2020).
25 von Hehn, C. A., Baron, R. & Woolf, C. J. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron 73, 638-652, doi:10.1016/j.neuron.2012.02.008 (2012).
26 Baron, R., Tolle, T. R., Gockel, U., Brosz, M. & Freynhagen, R. A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms. Pain 146, 34-40, doi:10.1016/j.pain.2009.06.001 (2009).
27 Forstenpointner, J., Rehm, S., Gierthmuhlen, J. & Baron, R. Stratification of neuropathic pain patients: the road to mechanism-based therapy? Curr Opin Anaesthesiol 31, 562-568, doi:10.1097/ACO.0000000000000642 (2018).
28 Attal, N. et al. Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomised, double-blind, placebo-controlled trial. The Lancet Neurology 15, 555-565, doi:10.1016/s1474-4422(16)00017-x (2016).
29 Attal, N., Rouaud, J., Brasseur, L., Chauvin, M. & Bouhassira, D. Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. 62, 218-225, doi:10.1212/01.WNL.0000103237.62009.77 %J Neurology (2004).
30 Edwards, R. R., Haythornthwaite, J. A., Tella, P., Max, M. B. & Raja, S. Basal heat pain thresholds predict opioid analgesia in patients with postherpetic neuralgia. Anesthesiology 104, 1243-1248, doi:10.1097/00000542-200606000-00020 (2006).
31 Finnerup, N. B., Sindrup, S. H., Bach, F. W., Johannesen, I. L. & Jensen, T. S. Lamotrigine in spinal cord injury pain: a randomized controlled trial. Pain 96, 375-383, doi:10.1016/s0304-3959(01)00484-5 (2002).
32 Freynhagen, R., Baron, R., Gockel, U. & Tolle, T. R. painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 22, 1911-1920, doi:10.1185/030079906X132488 (2006).
33 Bouhassira, D. et al. Development and validation of the Neuropathic Pain Symptom Inventory. Pain 108, 248-257, doi:10.1016/j.pain.2003.12.024 (2004).
34 Cleeland, C. S. & Ryan, K. M. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore 23, 129-138 (1994).
35 Kassambara, A. Practical Guide to Cluster Analysis in R: Unsupervised Machine Learning. (STHDA, 2017).
36 Monti, S., Tamayo, P., Mesirov, J. & Golub, T. J. M. l. Consensus clustering: a resampling-based method for class discovery and visualization of gene expression microarray data. 52, 91-118 (2003).
37 Wilkerson, M. D. & Hayes, D. N. ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinformatics 26, 1572-1573, doi:10.1093/bioinformatics/btq170 (2010).
38 Mealy, M. A. et al. Scrambler therapy improves pain in neuromyelitis optica: A randomized controlled trial. Neurology 94, e1900-e1907, doi:10.1212/WNL.0000000000009370 (2020).
39 Coyne, P. J., Wan, W., Dodson, P., Swainey, C. & Smith, T. J. A trial of Scrambler therapy in the treatment of cancer pain syndromes and chronic chemotherapy-induced peripheral neuropathy. J Pain Palliat Care Pharmacother 27, 359-364, doi:10.3109/15360288.2013.847519 (2013).
40 Pachman, D. R. et al. Pilot evaluation of Scrambler therapy for the treatment of chemotherapy-induced peripheral neuropathy. Support Care Cancer 23, 943-951, doi:10.1007/s00520-014-2424-8 (2015).
41 Sabato, A. F., Marineo, G. & Gatti, A. Scrambler therapy. Minerva Anestesiol 71, 479-482 (2005).
42 Smith, T. J., Coyne, P. J., Parker, G. L., Dodson, P. & Ramakrishnan, V. Pilot trial of a patient-specific cutaneous electrostimulation device (MC5-A Calmare(R)) for chemotherapy-induced peripheral neuropathy. J Pain Symptom Manage 40, 883-891, doi:10.1016/j.jpainsymman.2010.03.022 (2010).
43 Tomasello, C. et al. Scrambler therapy efficacy and safety for neuropathic pain correlated with chemotherapy-induced peripheral neuropathy in adolescents: A preliminary study. Pediatr Blood Cancer 65, e27064, doi:10.1002/pbc.27064 (2018).
44 Ko, Y. K., Lee, H. Y. & Lee, W. Y. Clinical experiences on the effect of scrambler therapy for patients with postherpetic neuralgia. Korean J Pain 26, 98-101, doi:10.3344/kjp.2013.26.1.98 (2013).
45 Smith, T. J. et al. A Pilot Randomized Sham-Controlled Trial of MC5-A Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN). J Palliat Care 35, 53-58, doi:10.1177/0825859719827589 (2020).
46 Truini, A. et al. Mechanisms of pain in distal symmetric polyneuropathy: a combined clinical and neurophysiological study. Pain 150, 516-521, doi:10.1016/j.pain.2010.06.006 (2010).
47 Truini, A. et al. Pathophysiology of pain in postherpetic neuralgia: a clinical and neurophysiological study. Pain 140, 405-410, doi:10.1016/j.pain.2008.08.018 (2008).
48 Truini, A., Garcia-Larrea, L. & Cruccu, G. Reappraising neuropathic pain in humans--how symptoms help disclose mechanisms. Nat Rev Neurol 9, 572-582, doi:10.1038/nrneurol.2013.180 (2013).
49 Truini, A. et al. Differential involvement of A-delta and A-beta fibres in neuropathic pain related to carpal tunnel syndrome. Pain 145, 105-109, doi:10.1016/j.pain.2009.05.023 (2009).
50 Wong, M. L., Fleming, L., Robayo, L. E. & Widerstrom-Noga, E. Utility of the Neuropathic Pain Symptom Inventory in people with spinal cord injury. Spinal Cord 58, 35-42, doi:10.1038/s41393-019-0338-5 (2020).
51 Galosi, E. et al. A pain in the skin. Regenerating nerve sprouts are distinctly associated with ongoing burning pain in patients with diabetes. Eur J Pain 22, 1727-1734, doi:10.1002/ejp.1259 (2018).
52 Kleggetveit, I. P. et al. High spontaneous activity of C-nociceptors in painful polyneuropathy. Pain 153, 2040-2047, doi:10.1016/j.pain.2012.05.017 (2012).
53 Mahn, F. et al. Sensory symptom profiles and co-morbidities in painful radiculopathy. PLoS One 6, e18018, doi:10.1371/journal.pone.0018018 (2011).
54 Ochoa, J. L., Campero, M., Serra, J. & Bostock, H. Hyperexcitable polymodal and insensitive nociceptors in painful human neuropathy. Muscle Nerve 32, 459-472, doi:10.1002/mus.20367 (2005).
55 Vlcková-Moravcová, E., Bednarík, J., Dusek, L., Toyka, K. V. & Sommer, C. Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Muscle Nerve 37, 50-60, doi:10.1002/mus.20889 (2008).