Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries, the major prognostic factors in PSCC are Pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, these factors are hard to precisely obtain before the operation. Besides, intermediate-risk patients with clinically non-palpable inguinal lymph nodes , only about 30% of them are able to detect micro-metastases after ILND. That means the rest of patients approximately 70% have no benefit from ILND and suffered from the complications of surgery, so we hope to find some biomarkers that help us to predict the outcome before surgery and reflect the inguinal lymph nodes metastatic.
Methods: A total of 349 consecutive patients of penile cancer at Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results.
Results: Multivariate analysis reveal NLR, LMR, PLR was significant independent factors was associated with inferior OS; Only PLR was associated with inferior PFS; LDH was not associated with inferior OS and PFS. Anatomic stage and lymph node status remained significant for OS and PFS as NCCN and EAU Guidelines indicated;The tumor type and primary treatment was not significant for OS and PFS. In logistic regression analyses NLR, LMR, PLR was corresponded to N stage which divided into the Node-negative group and Node-positive groups, however the LDH was not associated with the N stage. However Kendall’s tau-b evaluated the correlations, NLR, LMR, PLR were weakly correlated to the N stage.
Conclusions: NLR and LMR was significant independent factors for OS, PLR was significant independent factors both for OS and PFS. NLR, LMR, PLR was significant corresponded to N stage.