Taking Chengdu as the research object, the natural eco-environmental factors such as topography, climate, vegetation, land use and vegetation cover were selected, together with human disturbance factors such as traffic and GDP, and the index weights were calculated by AHP. Based on 3S technology, projection transformation, remote sensing interpretation, information extraction and analysis are carried out, and evaluation model of Chengdu's residential environment adaptability is constructed, which reflects the zoning and spatial distribution characteristics of Chengdu's residential environment adaptability. The results show that: 1) The adaptability index of Chengdu's human settlement environment is between 15.98 and 76.75, and the suitability of human settlement environment is gradually decreasing from the middle to the east and west of Chengdu, and most areas are restricted by human production activities and natural conditions. 2) According to the actual situation, the suitability index can be divided into High-grade suitable areas (284.36 km2, 2.01%), relatively High-grade suitable areas (1802.13 km2, 12.71%), moderately suitable areas (3721.49 km2, 26.24%) and low suitable areas (3731.49 km2, 26.31%). 3) The correlation degree between the spatial distribution of Chengdu population and each index factor is as follows: per capita GDP> topographic relief > temperature and humidity > vegetation coverage > traffic network density > land use > hydrological factors. 4) There is a good correlation between Chengdu human settlements suitability index and the current population density grid layer, and its correlation coefficient is 0.7326. 5) The leading impact indicators of human settlements in different regions are different. The results show that the natural environment conditions in Chengdu are superior and the ecological environment quality is relatively stable, but the human settlement suitability index in the southeast and Longmenshan areas of Chengdu is relatively low. Therefore, in the future development planning of Chengdu, it is necessary to combine the actual environmental conditions and resource carrying capacity, and rationally carry out urban optimization and beautiful countryside construction.