AMBADIPUDI, S., BIERNAT, J., RIEDEL, D., MANDELKOW, E. & ZWECKSTETTER, M. 2017. Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nat Commun, 8, 275.
APICCO, D. J., ASH, P. E. A., MAZIUK, B., LEBLANG, C., MEDALLA, M., AL ABDULLATIF, A., FERRAGUD, A., BOTELHO, E., BALLANCE, H. I., DHAWAN, U., BOUDEAU, S., CRUZ, A. L., KASHY, D., WONG, A., GOLDBERG, L. R., YAZDANI, N., ZHANG, C., UNG, C. Y., TRIPODIS, Y., KANAAN, N. M., IKEZU, T., COTTONE, P., LESZYK, J., LI, H., LUEBKE, J., BRYANT, C. D. & WOLOZIN, B. 2018. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci, 21, 72-80.
ARONOV, S., ARANDA, G., BEHAR, L. & GINZBURG, I. 2002. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. J Cell Sci, 115, 3817-27.
ARRIAGADA, P. V., GROWDON, J. H., HEDLEY-WHYTE, E. T. & HYMAN, B. T. 1992. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology, 42, 631-9.
ASAI, H., IKEZU, S., TSUNODA, S., MEDALLA, M., LUEBKE, J., HAYDAR, T., WOLOZIN, B., BUTOVSKY, O., KUGLER, S. & IKEZU, T. 2015. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci, 18, 1584-93.
BRAAK, H., ALAFUZOFF, I., ARZBERGER, T., KRETZSCHMAR, H. & DEL TREDICI, K. 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol, 112, 389-404.
BRAAK, H. & BRAAK, E. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol, 82, 239-59.
BRAAK, H. & BRAAK, E. 1996. Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis. Acta Neuropathol, 92, 197-201.
BRUNDIN, P., LI, J. Y., HOLTON, J. L., LINDVALL, O. & REVESZ, T. 2008. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci, 9, 741-5.
BUTTSTEDT, A., WINTER, R., SACKEWITZ, M., HAUSE, G., SCHMID, F. X. & SCHWARZ, E. 2010. Influence of the stability of a fused protein and its distance to the amyloidogenic segment on fibril formation. PLoS One, 5, e15436.
COLBY, D. W. & PRUSINER, S. B. 2011. De novo generation of prion strains. Nat Rev Microbiol, 9, 771-7.
CONGDON, E. E., LIN, Y., RAJAMOHAMEDSAIT, H. B., SHAMIR, D. B., KRISHNASWAMY, S., RAJAMOHAMEDSAIT, W. J., RASOOL, S., GONZALEZ, V., LEVENGA, J., GU, J., HOEFFER, C. & SIGURDSSON, E. M. 2016. Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy. Mol Neurodegener, 11, 62.
DEVOS, S. L., MILLER, R. L., SCHOCH, K. M., HOLMES, B. B., KEBODEAUX, C. S., WEGENER, A. J., CHEN, G., SHEN, T., TRAN, H., NICHOLS, B., ZANARDI, T. A., KORDASIEWICZ, H. B., SWAYZE, E. E., BENNETT, C. F., DIAMOND, M. I. & MILLER, T. M. 2017. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med, 9.
FITZPATRICK, A. W. P., FALCON, B., HE, S., MURZIN, A. G., MURSHUDOV, G., GARRINGER, H. J., CROWTHER, R. A., GHETTI, B., GOEDERT, M. & SCHERES, S. H. W. 2017. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 185-190.
FROST, B., JACKS, R. L. & DIAMOND, M. I. 2009. Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem, 284, 12845-52.
FURMAN, J. L. & DIAMOND, M. I. 2017. FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples. Methods Mol Biol, 1523, 349-359.
GASKIN, F., CANTOR, C. R. & SHELANSKI, M. L. 1975. Biochemical studies on the in vitro assembly and disassembly of microtubules. Ann N Y Acad Sci, 253, 133-46.
GOEDERT, M., JAKES, R., SPILLANTINI, M. G., HASEGAWA, M., SMITH, M. J. & CROWTHER, R. A. 1996. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature, 383, 550-3.
GOMEZ-RAMOS, A., DIAZ-HERNANDEZ, M., RUBIO, A., MIRAS-PORTUGAL, M. T. & AVILA, J. 2008. Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol Cell Neurosci, 37, 673-81.
GORLOVOY, P., LARIONOV, S., PHAM, T. T. & NEUMANN, H. 2009. Accumulation of tau induced in neurites by microglial proinflammatory mediators. FASEB J, 23, 2502-13.
GU, J., CONGDON, E. E. & SIGURDSSON, E. M. 2013. Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology. J Biol Chem, 288, 33081-95.
GUSTKE, N., TRINCZEK, B., BIERNAT, J., MANDELKOW, E. M. & MANDELKOW, E. 1994. Domains of tau protein and interactions with microtubules. Biochemistry, 33, 9511-22.
HERNANDEZ-VEGA, A., BRAUN, M., SCHARREL, L., JAHNEL, M., WEGMANN, S., HYMAN, B. T., ALBERTI, S., DIEZ, S. & HYMAN, A. A. 2017. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Rep, 20, 2304-2312.
HOLMES, B. B., DEVOS, S. L., KFOURY, N., LI, M., JACKS, R., YANAMANDRA, K., OUIDJA, M. O., BRODSKY, F. M., MARASA, J., BAGCHI, D. P., KOTZBAUER, P. T., MILLER, T. M., PAPY-GARCIA, D. & DIAMOND, M. I. 2013. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A, 110, E3138-47.
HOLMES, B. B. & DIAMOND, M. I. 2017. Cellular Models for the Study of Prions. Cold Spring Harb Perspect Med, 7.
HOLMES, B. B., FURMAN, J. L., MAHAN, T. E., YAMASAKI, T. R., MIRBAHA, H., EADES, W. C., BELAYGOROD, L., CAIRNS, N. J., HOLTZMAN, D. M. & DIAMOND, M. I. 2014. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A, 111, E4376-85.
HOLTZMAN, D. M., CARRILLO, M. C., HENDRIX, J. A., BAIN, L. J., CATAFAU, A. M., GAULT, L. M., GOEDERT, M., MANDELKOW, E., MANDELKOW, E. M., MILLER, D. S., OSTROWITZKI, S., POLYDORO, M., SMITH, S., WITTMANN, M. & HUTTON, M. 2016. Tau: From research to clinical development. Alzheimers Dement, 12, 1033-1039.
HUTTON, M., LENDON, C. L., RIZZU, P., BAKER, M., FROELICH, S., HOULDEN, H., PICKERING-BROWN, S., CHAKRAVERTY, S., ISAACS, A., GROVER, A., HACKETT, J., ADAMSON, J., LINCOLN, S., DICKSON, D., DAVIES, P., PETERSEN, R. C., STEVENS, M., DE GRAAFF, E., WAUTERS, E., VAN BAREN, J., HILLEBRAND, M., JOOSSE, M., KWON, J. M., NOWOTNY, P., CHE, L. K., NORTON, J., MORRIS, J. C., REED, L. A., TROJANOWSKI, J., BASUN, H., LANNFELT, L., NEYSTAT, M., FAHN, S., DARK, F., TANNENBERG, T., DODD, P. R., HAYWARD, N., KWOK, J. B., SCHOFIELD, P. R., ANDREADIS, A., SNOWDEN, J., CRAUFURD, D., NEARY, D., OWEN, F., OOSTRA, B. A., HARDY, J., GOATE, A., VAN SWIETEN, J., MANN, D., LYNCH, T. & HEUTINK, P. 1998. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature, 393, 702-5.
ISING, C., VENEGAS, C., ZHANG, S., SCHEIBLICH, H., SCHMIDT, S. V., VIEIRA-SAECKER, A., SCHWARTZ, S., ALBASSET, S., MCMANUS, R. M., TEJERA, D., GRIEP, A., SANTARELLI, F., BROSSERON, F., OPITZ, S., STUNDEN, J., MERTEN, M., KAYED, R., GOLENBOCK, D. T., BLUM, D., LATZ, E., BUEE, L. & HENEKA, M. T. 2019. NLRP3 inflammasome activation drives tau pathology. Nature, 575, 669-673.
KAMPERS, T., FRIEDHOFF, P., BIERNAT, J., MANDELKOW, E. M. & MANDELKOW, E. 1996. RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments. FEBS Lett, 399, 344-9.
KFOURY, N., HOLMES, B. B., JIANG, H., HOLTZMAN, D. M. & DIAMOND, M. I. 2012. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem, 287, 19440-51.
KONZACK, S., THIES, E., MARX, A., MANDELKOW, E. M. & MANDELKOW, E. 2007. Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci, 27, 9916-27.
KOREN, S. A., HAMM, M. J., MEIER, S. E., WEISS, B. E., NATION, G. K., CHISHTI, E. A., ARANGO, J. P., CHEN, J., ZHU, H., BLALOCK, E. M. & ABISAMBRA, J. F. 2019. Tau drives translational selectivity by interacting with ribosomal proteins. Acta Neuropathol, 137, 571-583.
LEE, G., COWAN, N. & KIRSCHNER, M. 1988. The primary structure and heterogeneity of tau protein from mouse brain. Science, 239, 285-8.
MEDINA, M. 2018. An Overview on the Clinical Development of Tau-Based Therapeutics. Int J Mol Sci, 19.
MERCKEN, M., FISCHER, I., KOSIK, K. S. & NIXON, R. A. 1995. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci, 15, 8259-67.
MICHEL, C. H., KUMAR, S., PINOTSI, D., TUNNACLIFFE, A., ST GEORGE-HYSLOP, P., MANDELKOW, E., MANDELKOW, E. M., KAMINSKI, C. F. & KAMINSKI SCHIERLE, G. S. 2014. Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem, 289, 956-67.
MIRBAHA, H., HOLMES, B. B., SANDERS, D. W., BIESCHKE, J. & DIAMOND, M. I. 2015. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. J Biol Chem, 290, 14893-903.
MOCANU, M. M., NISSEN, A., ECKERMANN, K., KHLISTUNOVA, I., BIERNAT, J., DREXLER, D., PETROVA, O., SCHONIG, K., BUJARD, H., MANDELKOW, E., ZHOU, L., RUNE, G. & MANDELKOW, E. M. 2008. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci, 28, 737-48.
MOSCHNER, K., SUNDERMANN, F., MEYER, H., DA GRACA, A. P., APPEL, N., PAULULAT, A., BAKOTA, L. & BRANDT, R. 2014. RNA protein granules modulate tau isoform expression and induce neuronal sprouting. J Biol Chem, 289, 16814-25.
NELSON, P. T., ALAFUZOFF, I., BIGIO, E. H., BOURAS, C., BRAAK, H., CAIRNS, N. J., CASTELLANI, R. J., CRAIN, B. J., DAVIES, P., DEL TREDICI, K., DUYCKAERTS, C., FROSCH, M. P., HAROUTUNIAN, V., HOF, P. R., HULETTE, C. M., HYMAN, B. T., IWATSUBO, T., JELLINGER, K. A., JICHA, G. A., KOVARI, E., KUKULL, W. A., LEVERENZ, J. B., LOVE, S., MACKENZIE, I. R., MANN, D. M., MASLIAH, E., MCKEE, A. C., MONTINE, T. J., MORRIS, J. C., SCHNEIDER, J. A., SONNEN, J. A., THAL, D. R., TROJANOWSKI, J. Q., TRONCOSO, J. C., WISNIEWSKI, T., WOLTJER, R. L. & BEACH, T. G. 2012. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol, 71, 362-81.
NOVAK, P., SCHMIDT, R., KONTSEKOVA, E., ZILKA, N., KOVACECH, B., SKRABANA, R., VINCE-KAZMEROVA, Z., KATINA, S., FIALOVA, L., PRCINA, M., PARRAK, V., DAL-BIANCO, P., BRUNNER, M., STAFFEN, W., RAINER, M., ONDRUS, M., ROPELE, S., SMISEK, M., SIVAK, R., WINBLAD, B. & NOVAK, M. 2017. Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Neurol, 16, 123-134.
OCHIISHI, T., DOI, M., YAMASAKI, K., HIROSE, K., KITAMURA, A., URABE, T., HATTORI, N., KINJO, M., EBIHARA, T. & SHIMURA, H. 2016. Development of new fusion proteins for visualizing amyloid-beta oligomers in vivo. Sci Rep, 6, 22712.
PAPASOZOMENOS, S. C. & BINDER, L. I. 1987. Phosphorylation determines two distinct species of Tau in the central nervous system. Cell Motil Cytoskeleton, 8, 210-26.
PICKHARDT, M., GAZOVA, Z., VON BERGEN, M., KHLISTUNOVA, I., WANG, Y., HASCHER, A., MANDELKOW, E. M., BIERNAT, J. & MANDELKOW, E. 2005. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J Biol Chem, 280, 3628-35.
PICKHARDT, M., LARBIG, G., KHLISTUNOVA, I., COKSEZEN, A., MEYER, B., MANDELKOW, E. M., SCHMIDT, B. & MANDELKOW, E. 2007. Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. Biochemistry, 46, 10016-23.
PICKHARDT, M., NEUMANN, T., SCHWIZER, D., CALLAWAY, K., VENDRUSCOLO, M., SCHENK, D., ST GEORGE-HYSLOP, P., MANDELKOW, E. M., DOBSON, C. M., MCCONLOGUE, L., MANDELKOW, E. & TOTH, G. 2015. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Curr Alzheimer Res, 12, 814-28.
POOLER, A. M., PHILLIPS, E. C., LAU, D. H., NOBLE, W. & HANGER, D. P. 2013. Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep, 14, 389-94.
SANTACRUZ, K., LEWIS, J., SPIRES, T., PAULSON, J., KOTILINEK, L., INGELSSON, M., GUIMARAES, A., DETURE, M., RAMSDEN, M., MCGOWAN, E., FORSTER, C., YUE, M., ORNE, J., JANUS, C., MARIASH, A., KUSKOWSKI, M., HYMAN, B., HUTTON, M. & ASHE, K. H. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science, 309, 476-81.
VAQUER-ALICEA, J. & DIAMOND, M. I. 2019. Propagation of Protein Aggregation in Neurodegenerative Diseases. Annu Rev Biochem, 88, 1-26.
VON BERGEN, M., FRIEDHOFF, P., BIERNAT, J., HEBERLE, J., MANDELKOW, E. M. & MANDELKOW, E. 2000. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. Proc Natl Acad Sci U S A, 97, 5129-34.
WALSH, D. M. & SELKOE, D. J. 2016. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci, 17, 251-60.
WANG, Y., BALAJI, V., KANIYAPPAN, S., KRUGER, L., IRSEN, S., TEPPER, K., CHANDUPATLA, R., MAETZLER, W., SCHNEIDER, A., MANDELKOW, E. & MANDELKOW, E. M. 2017. The release and trans-synaptic transmission of Tau via exosomes. Mol Neurodegener, 12, 5.
WANG, Y. & MANDELKOW, E. 2016. Tau in physiology and pathology. Nat Rev Neurosci, 17, 5-21.
WEGMANN, S., EFTEKHARZADEH, B., TEPPER, K., ZOLTOWSKA, K. M., BENNETT, R. E., DUJARDIN, S., LASKOWSKI, P. R., MACKENZIE, D., KAMATH, T., COMMINS, C., VANDERBURG, C., ROE, A. D., FAN, Z., MOLLIEX, A. M., HERNANDEZ-VEGA, A., MULLER, D., HYMAN, A. A., MANDELKOW, E., TAYLOR, J. P. & HYMAN, B. T. 2018. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J, 37.
WEGMANN, S., JUNG, Y. J., CHINNATHAMBI, S., MANDELKOW, E. M., MANDELKOW, E. & MULLER, D. J. 2010. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem, 285, 27302-13.
WILCOCK, G. K., GAUTHIER, S., FRISONI, G. B., JIA, J., HARDLUND, J. H., MOEBIUS, H. J., BENTHAM, P., KOOK, K. A., SCHELTER, B. O., WISCHIK, D. J., DAVIS, C. S., STAFF, R. T., VUKSANOVIC, V., AHEARN, T., BRACOUD, L., SHAMSI, K., MAREK, K., SEIBYL, J., RIEDEL, G., STOREY, J. M. D., HARRINGTON, C. R. & WISCHIK, C. M. 2018. Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial. J Alzheimers Dis, 61, 435-457.
WISCHIK, C. M., HARRINGTON, C. R. & STOREY, J. M. 2014. Tau-aggregation inhibitor therapy for Alzheimer's disease. Biochem Pharmacol, 88, 529-39.
WISCHIK, C. M., NOVAK, M., THOGERSEN, H. C., EDWARDS, P. C., RUNSWICK, M. J., JAKES, R., WALKER, J. E., MILSTEIN, C., ROTH, M. & KLUG, A. 1988. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A, 85, 4506-10.
WOBST, H. J., SHARMA, A., DIAMOND, M. I., WANKER, E. E. & BIESCHKE, J. 2015. The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios. FEBS Lett, 589, 77-83.
WU, J. W., HUSSAINI, S. A., BASTILLE, I. M., RODRIGUEZ, G. A., MREJERU, A., RILETT, K., SANDERS, D. W., COOK, C., FU, H., BOONEN, R. A., HERMAN, M., NAHMANI, E., EMRANI, S., FIGUEROA, Y. H., DIAMOND, M. I., CLELLAND, C. L., WRAY, S. & DUFF, K. E. 2016. Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci, 19, 1085-92.
YAMADA, K., CIRRITO, J. R., STEWART, F. R., JIANG, H., FINN, M. B., HOLMES, B. B., BINDER, L. I., MANDELKOW, E. M., DIAMOND, M. I., LEE, V. M. & HOLTZMAN, D. M. 2011. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci, 31, 13110-7.
YANAMANDRA, K., KFOURY, N., JIANG, H., MAHAN, T. E., MA, S., MALONEY, S. E., WOZNIAK, D. F., DIAMOND, M. I. & HOLTZMAN, D. M. 2013. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron, 80, 402-14.
YANG, F., MOSS, L. G. & PHILLIPS, G. N., JR. 1996. The molecular structure of green fluorescent protein. Nat Biotechnol, 14, 1246-51.
ZEMPEL, H., LUEDTKE, J., KUMAR, Y., BIERNAT, J., DAWSON, H., MANDELKOW, E. & MANDELKOW, E. M. 2013. Amyloid-beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. EMBO J, 32, 2920-37.
ZHANG, X., LIN, Y., ESCHMANN, N. A., ZHOU, H., RAUCH, J. N., HERNANDEZ, I., GUZMAN, E., KOSIK, K. S. & HAN, S. 2017. RNA stores tau reversibly in complex coacervates. PLoS Biol, 15, e2002183.