This paper investigates the dynamics of two-spin nonlocality generation in a Heisenberg XXX chain with Dzyaloshinskii-Moriya (DM) and Kaplan-Shekhtman-Entin-Wohlman-Aharony (KSEA) interactions. We analyze the two-spin nonlocality dynamics by using uncertainty-induced nonlocal-ity, maximal Bell inequality, and log-negativity. We demonstrate that a separable two-spin Heisen-berg XXX chain state, induced by two-spin antiferromagnetic interaction as well as x-component of DM and KSEA interactions, could evolve to maximal two-spin nonlocality state. The ability of preserving the maximal uncertainty-induced nonlocality can be enhanced by increasing the coupling strength of the spin-spin interaction coupling. The hierarchy principle is maintained for the two-spin Bell nonlocality and log-negativity entanglement. The two-spin log-negativity dynamics exhibits the phenomenon of sudden death and birth as a result of the intrinsic decoherence, which also causes a reduction in the two-spin nonlocalities. The two-spin uncertainty-induced nonlocality is more robust , against the intrinsic decoherence, than the other types of the nonlocality. The results indicate that by boosting the two-spin antiferromagnetic interaction, the produced nonlocalities (resulting from the DM and KSEA x-component interactions) can be shielded from the intrinsic decoherence effect.