[1] World Health Organization (2018) Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed 29 March 2020
[2] Cancer Research UK (2018) Worldwide cancer incidence statistics. https://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer/incidence. Accessed 29 March 2020
[3] Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L (2016) Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol 13:674–690. https://doi.org/10.1038/nrclinonc.2016.66
[4] Kleeff J, Korc M, Apte M, La Vecchia C, Johnson CD, Biankin A V, Neale RE, Tempero M, Tuveson DA, Hruban RH, Neoptolemos JP (2016) Pancreatic cancer. Nat Rev Dis Prim 2:16022. https://doi.org/10.1038/nrdp.2016.22
[5] Grant C V, Carver CM, Hastings SD, Ramachandran K, Muniswamy M, Risinger AL, Beutler JA, Mooberry SL (2019) Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. Breast Cancer Res Treat 177:345–355. https://doi.org/10.1007/s10549-019-05324-7
[6] Gonçalves LM, Valente IM, Rodrigues JA (2014) An overview on cardamonin. J Med Food 17:633–640. https://doi.org/10.1089/jmf.2013.0061
[7] Break MKB, Chiang M, Wiart C, Chin CF, Khoo A, Khoo TJ (2020) Cytotoxic activity of Boesenbergia rotunda extracts against nasopharyngeal carcinoma cells (HK1). Cardamonin, a Boesenbergia rotunda constituent, inhibits growth and migration of HK1 cells by inducing caspase-dependent apoptosis and G2/M–phase arrest. Nutr Cancer 1-11. https://doi.org/10.1080/01635581.2020.1751217
[8]. Shrivastava S, Jeengar MK, Thummuri D, Koval A, Katanaev VL, Marepally S, Naidu VGM (2017) Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial–mesenchymal transition. BioFactors 43:152–169. https://doi.org/10.1002/biof.1315
[9] Nawaz J, Rasul A, Shah MA, Hussain G, Riaz A, Sarfraz I, Zafar S, Adnan M, Khan AH, Selamoglu Z (2020) Cardamonin: A new player to fight cancer via multiple cancer signaling pathways. Life Sci 250. https://doi.org/10.1016/j.lfs.2020.117591
[10] Kong W, Li C, Qi Q, Shen J, Chang K (2020) Cardamonin induces G2/M arrest and apoptosis via activation of the JNK–FOXO3a pathway in breast cancer cells. Cell Biol Int 44:177–188. https://doi.org/10.1002/cbin.11217
[11] Break MKB, Hossan MS, Khoo Y, Qazzaz ME, Al-Hayali MZK, Chow SC, Wiart C, Bradshaw TD, Collins H, Khoo T-J (2018) Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway. Fitoterapia 125:161–173. https://doi.org/https://doi.org/10.1016/j.fitote.2018.01.006
[12] Qazzaz ME, Raja VJ, Lim K-H, Kam T-S, Lee JB, Gershkovich P, Bradshaw TD (2016) In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer Lett 370:185–197. https://doi.org/https://doi.org/10.1016/j.canlet.2015.10.013
[13] Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK, Heery DM (2013) Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. BMC Cancer 13:37. https://doi.org/10.1186/1471-2407-13-37
[14] Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G, Kim JW, Gatza M, Murphy S, Nevins JR (2009) Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene 28:2796–2805. https://doi.org/10.1038/onc.2009.139
[15] Nandakumar N, Muthuraman S, Gopinath P, Nithya P, Gopas J, Kumar RS (2017) Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity. Eur J Med Chem 125:1076–1087. https://doi.org/https://doi.org/10.1016/j.ejmech.2016.10.047
[16] Wu C-F, Efferth T (2015) Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells. J Nat Prod 78:1339–1347. https://doi.org/10.1021/acs.jnatprod.5b00158
[17] Sone K, Piao L, Nakakido M, Ueda K, Jenuwein T, Nakamura Y, Hamamoto R (2014) Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nat Commun 5:5691. https://doi.org/10.1038/ncomms6691
[18] Hossan MS, Chan Z-Y, Collins HM, Shipton FN, Butler MS, Rahmatullah M, Lee JB, Gershkovich P, Kagan L, Khoo T-J, Wiart C, Bradshaw TD (2019) Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition. Cancer Lett 453:57–73. https://doi.org/https://doi.org/10.1016/j.canlet.2019.03.034
[19] Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim K-H, Kam T-S, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE (2018) Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site. Sci Rep 8:10617. https://doi.org/10.1038/s41598-018-28880-2
[20] Vizetto-Duarte C, Custódio L, Gangadhar KN, Lago JHG, Dias C, Matos AM, Neng N, Nogueira JMF, Barreira L, Albericio F, Rauter AP, Varela J (2016) Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleava. Phytomedicine 23:550–557. https://doi.org/https://doi.org/10.1016/j.phymed.2016.02.008
[21] Gong L, Tang Y, An R, Lin M, Chen L, Du J (2017) RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death & Dis 8:e3080
[22] Tsang WP, Chau SPY, Kong SK, Fung KP, Kwok TT (2003) Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis. Life Sci 73:2047–2058. https://doi.org/https://doi.org/10.1016/S0024-3205(03)00566-6
[23] Tang Y, Fang Q, Shi D, Niu P, Chen Y, Deng J (2014) mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion. Life Sci 99:44–51. https://doi.org/https://doi.org/10.1016/j.lfs.2014.01.066
[24] Niu P, Li J, Chen H, Zhu Y, Zhou J, Shi D (2020) Anti-proliferative effect of cardamonin on mTOR inhibitor-resistant cancer cells. Mol Med Rep 21:1399–1407. https://doi.org/10.3892/mmr.2019.10898
[25] Xue Z-G, Niu P-G, Shi D-H, Liu Y, Deng J, Chen Y-Y (2015) Cardamonin Inhibits Angiogenesis by mTOR Downregulation in SKOV3 Cells. Planta Med 82:70–75. https://doi.org/10.1055/s-0035-1557901
[26] Zhou X, Zhou R, Li Q, Jie X, Hong J, Zong Y, Dong X, Zhang S, Li Z, Wu G (2019) Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway. Anticancer Drugs 30:241-250. https://doi.org/10.1097/CAD.0000000000000709
[27] Costa RLB, Han HS, Gradishar WJ (2018) Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review. Breast Cancer Res Treat 169:397–406. https://doi.org/10.1007/s10549-018-4697-y
[28] Wei R, Cortez Penso NE, Hackman RM, Wang Y, Mackenzie GG (2019) Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine. Nutr. 11:1856. https://doi.org/10.3390/nu11081856
[29] Hu M-H, Wu T-Y, Huang Q, Jin G (2019) New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription. Nucleic Acids Res 47:10529–10542. https://doi.org/10.1093/nar/gkz835
[30] Skoudy A, Hernández-Muñoz I, Navarro P (2011) Pancreatic Ductal Adenocarcinoma and Transcription Factors: Role of c-Myc. J Gastrointest Cancer 42:76–84. https://doi.org/10.1007/s12029-011-9258-0
[31] Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, Ellenrieder V (2006) Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 25:3714–3724. https://doi.org/10.1038/sj.emboj.7601246
[32] Yu Q, Zhou X, Xia Q, Shen J, Yan J, Zhu J, Li X, Shu M (2016) Long non-coding RNA CCAT1 that can be activated by c-Myc promotes pancreatic cancer cell proliferation and migration. Am J Transl Res 8:5444–5454.
[33] Sodir NM, Kortlever RM, Barthet VJA, Campos T, Pellegrinet L, Kupczak S, Anastasiou P, Brown Swigart L, Soucek L, Arends MJ, Littlewood TD, Evan GI (2020) Myc instructs and maintains pancreatic adenocarcinoma phenotype. Cancer Discov CD-19-0435. https://doi.org/10.1158/2159-8290.CD-19-0435