1 | Effect of Components | | Astrodaucus persicus (Boiss.) Drude | T47D cell line | Prolifration ↓(insignificantly) | (32) |
Doxorubicin | T47D cell line | Prolifration ↓ |
2 | Effect of Components | cyclin D1 | Crocin (from Crocus sativus L.) | Rats | ↓ Expression | (122) |
3 | Effect of Components | | Marrubium persicum | MCF-7 cell line | Prolifration ↓ | (123) |
4 | New Technologies | | trastuzumab-multiwalled carbon nanotubes | SK-BR-3 cell line | ↓ Cell viability | (33) |
trastuzumab-multiwalled carbon nanotubes | MCF-7 cell line | No effect on Cell viability |
trastuzumab-diphtheria toxin | SK-BR-3 cell line | ↓ Cell viability |
trastuzumab-diphtheria toxin | MCF-7 cell line | No effect on Cell viability |
5 | New Technologies | | Silver Nanoparticles and Ions | Parent and tamoxifen-resistant T47D cell lines | ↓ Cell viability | (124) |
6 | Effect of Components | | Cadmium and Copper Chloride | MDA-MB468 cell line | ↓ Cell viability | (125) |
7 | Effect of Components | BRCA1, ATM, Bak, p53, p21 | Silibinin | MCF7 Cell line | ↑ Genes Expression, ↓ Cell Prolifration, ↑ Cell Apoptosis | (126) |
Bcl-xl | ↓ Gene Expression |
8 | New Technologies | | 2-(3,5-Dihydroxyphenyl) -6-hydroxybenzothiazole | MDA-MB-231 | ↑ Apoptosis, Arrest of Prolifration | (127) |
9 | New Technologies | | Dimethyl-5-acetyl-4-methyl-6-(4-methylphenylimino)-6H-thiopyran-2,3-dicarboxylate | MCF-7 cell line | ↓ proliferation | (128) |
10 | New Technologies | | A naphthalene-fused (a-alkoxycarbonyl)methylene-g-butyrolactone (methyl 2-[7-hydroxy-2-oxonaphtho[1,2- b]furan-3(2H)-yliden]acetate) | MCF-7 cell line | ↓ proliferation | (129) |
11 | New Technologies | | 2-(3,5-Dihydroxyphenyl)-6- Hydroxybenzothiazole | MCF-7 cell line | ↓ Proliferation | (130) |
12 | New Technologies | | 177Lu–DOTA–trastuzumab | MCF-7 cell line | ↓ Cell viability | (34) |
13 | Effect of Components | | 177Lu-DOTA-trastuzumab | SKBr3 and MCF7 cell lines | ↓ Cell viability | (35) |
14 | Effect of Components | | Silimarin and Doxorubicin | MCF-7 cell line | ↑Apoptosis | (36) |
15 | Effect of Components | | Baneh and Doxorubicin | T47D cell line | ↑Apoptosis | (37) |
16 | Effect of Components | cyclin D1, cdk4, CyclinA, cdk2 | Baneh | T47D cell line | ↓ Expression | (131) |
Cyclin E, cdk1, CyclinB1 | ↑Expression |
17 | Effect of Components | | Crab Shell | MCF-7 cell line | ↓Proliferation (↑Apoptosis, ↓Nitric oxide level) | (132) |
18 | Effect of Components | Mre11 | Lithium chloride | T47D cell line | ↓ DNA repair,↓ Expression | (133) |
19 | Effect of Components | Mre11 | Lithium chloride | T47D cell line | ↓ DNA repair, ↓ Expression | (134) |
20 | Effect of Components | | letulin and dexorubicin | MDA-MB 231 | ↑ Cell death | (135) |
Nrf2, Ho1, MDR1 | luteolin-loaded nanoparticles | | ↓ Expression |
21 | Effect of Components | | Viola tricolor(EtOAc, n-butanol, and H2O fractions and Hydroalcoholic extract ) | Neuro2a mouse neuroblastoma and MCF-7 cell line and normal L929 cells | ↑ Cell death, ↑Apoptosis(caspase-dependent) | (136) |
22 | Effect of Components | | Metformin | MCF-7, BT-474, SK-BR-3 and MDA-MB-231 cell lines +/_ Paclitaxel | No effect on Cell viability and paclitaxel cytotoxicity | (137) |
23 | Effect of Components | | ZnO nanoparticles | Du145 and T-47D cell lines | Significant lethal effects | (138) |
ZnO-MTCP and ZnO-CuMTCP | Du145 and T-47D cell lines | No cytotoxic effects |
ZnO-MTCP + UV light exposure | T-47D cell line | ↓ Survival |
24 | Effect of Components | | palladium(II) complex +/- calf thymus DNA | T-47D cell line | ↓ Cell proliferation | (139) |
25 | Effect of Components | | AuNP-Conjugated/ Non-conjugated 2-amino- 4H-chromene-3-carbonitrile | T-47D cell line | ↓ Cell viability | (140) |
26 | Effect of Components | | Noscapine and papaverine | MCF-7 and MDA-MB-231 cell lines | ↑Apoptosis of CSCs | (141) |
27 | Effect of Components | | (1)polypyridyl-based copper(II) complexes [Cu(tpy)(dppz)](NO3)2 and (2)polypyridyl-based copper(II) complexes [Cu(tptz)2](NO3)2 | MCF-7 cell line | ↑Apoptosis | (142) |
28 | Effect of Components | | ethanolic extract of Alpinia galanga rhizhome | MCF-7 cell line | ↓ Cell viability | (143) |
29 | Biomarkers | PDE9 | inhibitor BAY 73-6691 | MCF-7 and MDA-MB-468 cell lines | ↓ Expression, ↓cell proliferation, ↑Apoptosis | (144) |
30 | Effect of Components | Survivin | Piperine | Triple-negative breast cancer cells in vitro and in vivo | Inhibition of Survivin, ↑Apoptosis | (145) |
31 | Effect of Components | | Mitoxantrone (MX) + ionizing radiation and photodynamic therapy | MCF-7 cell line | ↑ Cell death, ↓ Cell viability | (146) |
32 | Biomarkers | FBXO39 | | MCF-7 cell line | Expressed | (147) |
TDRD4, FBXO39 | | MDA-MB-231 cell line | Expressed |
FBXO39 | RHOXF1 shRNA | invasive ductal carcinoma samples and MDA-MB-231 cell line | ↑Expression |
FBXO39 | RHOXF1 shRNA | MCF-7 cell line | ↓ Expression |
TDRD4 | RHOXF1 shRNA | MDA-MB-231 cell line | ↑Expression |
33 | Effect of Components | | SN38 (7-ethyl-10-hydroxyl camptothecin) and SN38-NPs | 4T1 breast cancer cells and xenograft balb/c animal | ↑Cytotoxicity | (148) |
34 | Effect of Components | | Myrsinane-type compounds: 3,7,14,15-tetraacetyl-5-propanoyl-13(17)-epoxy-8,10(18)-myrsinadiene (1) and 3,7,10,14,15-pentaacetyl-5-butanoyl-13,17-epoxy-8- myrsinene (2) | MCF-7 and MDA-MB 468 cell lines | Moderate Cytotoxicity | (149) |
| | Jatrophane-type diterpene: 5,6-epoxy-8,9,15-triacetyl-3- benzoyl-14-oxo-jatropha-11(E)-ene (3) | Weak Cytotoxicity |
35 | Effect of Components | | artemisinin + Miconazole + Butyric acid + Iron sulfate | 4T1 breast cancer cells | ↑Apoptosis | (150) |
36 | Effect of Components | | pegylated liposomal trans-anethole | MCF-7 and T47D cell lines | ↑Cytotoxicity | (151) |
37 | New Technologies | Th1, Th2 and Treg | (TNF-a/CD40L)-MSCs + DCs | 4T1 injected BALB/c mouse | ↓ Expression, ↓Tumor progression,↑Survival | (152) |
38 | Effect of Components | HER-2 | recombinant λ phage C-Myc tagged | SKBR-3 and MCF-7 cell lines | ↓Cell growth | (153) |
39 | Effect of Components | | [Cd2(Dic)41.5(MeOH)2(H2O)]n (Dic = diclofenac sodium ) | MCF7,T24,L-929 and A-549 cell lines | ↓Cell proliferation | (154) |
[Cd2(Dic)41.5(MeOH)2(H2O)]n in comparison with Dic and Cd2 | MCF7,T24 cell lines | ↑Cytotoxicity |
40 | Effect of Components | | Equol(metabolite of the soybean isoflavone daidzein) | MDA-MB231(IC50:252 µM) and T47D(IC50 228 µM) | ↓ Cell proliferation | (155) |
MDA-MB-231(IC50 50 µM and T47D(IC50 50 µM) | ↑Radiation-induced apoptosis |
41 | New Technologies | | methotrexate–human serum albu- min nanoparticles(MTX–HSA NPs) with luteinizing-hormone releasing hormone(LHRH) | Female Balb/c mice bearing 4T1 cell line | ↑ Survival | (156) |
42 | Biomarkers | MMP-3,MMP-9 and TIMP-1 cell lines | | Female Balb/c mice bearing adenocarcinoma breast tumor + Candida Albicans, Female BALB/c mice was infected Candida Albicans and Female Balb/c mice bearing adenocarcinoma breast tumor | ↑Secretion | (157) |
MMP-2 | Female Balb/c mice bearing adenocarcinoma breast tumor + Candida Albicans and Female BALB/c mice was infected Candida Albicans | ↓Secretion |
43 | Effect of Components | Extracellular Signal-Regulated Kinases 1/2 (ERK) and phospho-ERK | DOX | MDA-MB-231 (ER-) cell line | ↓ Expression | (158) |
Extracellular Signal-Regulated Kinases 1/2 and phospho-ERK | DOX | MCF-7 (ER+) cell line | ↑ Expression |
Extracellular Signal-Regulated Kinases 1/2 (ERK) and phospho-ERK | DOCT | MDA-MB-231 (ER-) cell line | ↓ Expression |
Extracellular Signal-Regulated Kinases 1/2 (ERK) and phospho-ERK | DOCT | MCF-7 (ER+) cell line | ↑ Expression |
44 | Immunotherapy-Immunology | HER2 | anti-HER2 mAbs 1T0, 2A8 and both | BT474 cell line | ↓Cell proliferation | (38) |
trastuzumab, 1T0 and 2A8 | significant synergistic ↓Cell proliferation |
45 | Effect of Components | | Proline-rich heptapeptide 11a–b and 11i–j | HL60,MCF7 and A549 cell lines | little or no effect on cell viability | (159) |
Proline-rich heptapeptide 11e | A549 and MCF7 cell lines | little or no effect on cell viability |
Proline-rich heptapeptide 11d and 11 h | MCF7 cell line | 60% effect on cell viability |
Proline-rich heptapeptide 11c and 11 g | MCF7 cell line | 10% effect on cell viability |
46 | Effect of Components | EGFR | ASOND-loaded chitosan particles | T47D cell line | Downregulated expression | (160) |
ASOND-loaded thiolated particles | ↓ Expression |
47 | Effect of Components | | 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) | MCF7 and MDA-MB-231 cell lines | ↓Cell growth, induce apoptosis | (161) |
48 | Effect of Components | 15-Lipoxygenase-1 | Trichostatin A (TSA) | MCF7 and MDA-MB-231 cell lines | ↓ Cell viability and cell growth, induce apoptosis | (162) |
49 | Effect of Components | | Methanol extract of Salvia chloroleuca,n-hexane and CH2Cl2 | MCF-7 cell line | ↓ Cell viability | (163) |
CH2Cl2 | Apoptosis |
Total methanol extract of S. chloroleuca,n-hexane,CH2Cl2EtOAc, n-BuOH, and H2O | ↓Cell growth |
50 | Effect of Components | miR-145 | Chitosan polyplex nanoparticles | MCF-7 cell line | ↓Cell proliferation | (164) |
51 | Effect of Components | | (pH-sensitive)MTO PEG-PMMI- CholC6 and CHEMS-based bearing niosomes | HUVEC,OVCAR-3 and MCF-7 Cell lines | ↑Antiproliferative activity | (165) |
(pH-sensitive)MTO conventional, PEG-PMMI- CholC6 and CHEMS-based bearing niosomes | HUVEC,OVCAR-3 and MCF-7 Cell lines | ↑ Cytotoxicity |
(pH-sensitive)MTO conventional, PEG-PMMI- CholC6 and CHEMS-based bearing niosomes | OVCAR-3 and MCF-7 Cell lines | ↓ Cell viability |
52 | Effect of Components | | Valproic acid (VPA) | MCF-7 cell line | ↓Cell viability, Apoptosis | (166) |
Telomerase | Valproic acid (VPA) | ↓Activity |
Bax/Bcl-2 | Valproic acid (VPA) | ↑Bax and ↓Bcl-2 expression and ↑Bax/Bcl‐2 ratio |
Telomerase activity &↑in Bax/Bcl-2 ratio | | significant correlation |
53 | Effect of Components | | Scrophularia oxysepala(n-hexane extract) | MCF-7 cell line | no cytotoxic effects | (167) |
Scrophularia oxysepala(dichloromethae and methanol extract) | ↓Cell growth,↓ viability, apoptosis |
54 | Effect of Components | p53 | Boswellia Thurifera Gum Methanol Extract | MDA-MB-231 cell line | ↑Expression, cytotoxic effect | (168) |
55 | Effect of Components | | docetaxel-coated Fe3O4 MNPs | 4 T1 cell line | ↑Cell death than docetaxel alone | (169) |
56 | Effect of Components | | Lactobacillus plantarum enriched with selenium nanoparticles(SeNPs) | FemaleBALB/c mice with 4T1 cell line | ↓Growth rate of tumors,↓Rate of death,↑ Survival | (169) |
IFN-γ, TNF-α and IL-2 | Lactobacillus plantarum enriched with selenium nanoparticles(SeNPs) | Female BALB/c mice with 4T1 cell line | ↑Production,↑NK cells cytotoxicity |
LDH | | | ↓Production |
57 | Effect of Components | | Selenium nanoparticle(SeNPs)-enriched Lactobacillus brevis | Female BALB/c mice with 4T1 cell line | ↓Growth rate of tumors,↓Rate of death,↑ Survival,↑Tumor necrosis,↓Metastasis | (170) |
IFN-γ and IL-17 | ↑Production,↑NK cells cytotoxicity |
LDH and ALP | ↓Production |
58 | Effect of Components | | Biogenic Selenium Nanoparticles | Female BALB/c mice with 4T1 cell line | ↓Growth rate of tumors,↓Rate of death,↑ Survival | (171) |
IFN-γ, IL-12, IL-2, and TNF-α | | ↑production |
59 | Immunotherapy-Immunology | | TGFaL3-SEB | 4T1 cell line | ↑Antitumor activities | (172) |
60 | Effect of Components | | Curcumin-loaded NIPAAm-MAA | MCF-7 cell line | More cytotoxic effect and efficiently ↓cell growth than curcumin alone | (173) |
61 | Effect of Components | Autocrine hGH (Human growth hormone) | Arsenic trioxide (ATO) | MCF7-hGH than MCF-7 cell line | ↑Expression, ↓ Cell viability, ↓ colony formation, ↑Apoptosis | (174) |
62 | Effect of Components | | Lactobacillus Rhamnosus, cisplatin, Lactobacillus Rhamnosus + cisplatin | Female BALB/c Mice | ↓Growth rate of tumors | (175) |
63 | Effect of Components | IFN-γ | aqueous extract of Carica papaya leaves | Female BALB/c Mice | ↑Expression, ↓Growth rate of tumors | (175) |
IL- 4 | | ↓Expression |
64 | Effect of Components | HER2 | Silybin | SKBR3 cell line | ↓Cell growth, ↓Expression | (176) |
65 | Effect of Components | | Neutra Charged liposomes-encapsulated Doxorubicin | MDA-MB-231 cell line | More cytotoxic effec than Negative Charged liposomes-encapsulated Doxorubicin and free Doxorubicin | (39) |
66 | Effect of Components | | Artemisia absinthium L.(Grown at high height) | MCF7 cell line | ↑Cytotoxicity than others | (177) |
67 | Effect of Components | | Acetazolamide | T47-D cell line | No effect on apoptosis and cell cycle arrest | (178) |
68 | Effect of Components | | Methanolic extract of Avicennia marina | MDA-MB231 cell line | ↓Cell growth and induce apoptosis more than other extraction | (179) |
Ethanolic extract of Avicennia marina | ↑Cytotoxicity more than other extraction |
69 | Effect of Components | | Letrozole loaded lipid nanocapsules (LNCs) | MCF7 cell line | ↓Cytotoxicity in comparison with free letrozole | (180) |
70 | Effect of Components | CD83 | Melphalan alkylating + TNF-α and MCM | MCF7 cell line | ↑Expression, ↓Phagocytosis, polarized immune responses to DC1 phenotype triggering TH1 responses | (181) |
71 | Effect of Components | | Ethanolic Extract of ginger fresh extract (Zingiber) | MCF7 cell line | ↓Cell growth, Cytotoxic effect, induce apoptosis | (182) |
72 | Effect of Components | Telomerase | Curcuma longa n-hexane extract | MCF7 cell line | ↓Expression, ↓Cell growth | (183) |
73 | Effect of Components | | Saffron | MCF7 cell line | ↓ Cell viability, induce apoptosis | (184) |
74 | Effect of Components | | Lactobacillus Reuteri | Female BALB/c Mice | ↓Growth rate of tumors, ↑Weight, ↑Survival, ↑Tumor Cell death | (185) |
75 | Biomarkers | interlukin-6 (IL-6) and Vascular endothelial growth factor (VEGF) | Rest-tumor-exercise(RTE) and Rest-tumor-rest (RTR) | Female BALB/c with MC4L2 cell line | ↑Expression | (186) |
Rest-tumor-rest (RTR) and Exercise-tumor-rest (ETR) | ↑Growth rate of tumors |
76 | Biomarkers | 2H1-TP, KALA-2H1-TP and KALA-2H1-NLS-TP | histone H1-based recombinant fusion peptide | ZR-75-1 cell line(P control) MDA-MB-231 cell line(N control) | No significant cytotoxicity effect and cell viability | (187) |
77 | Immunotherapy-Immunology | INF-γ and IL-4 | Lip-DOPE-P5-MPL | Female BALB/c mice with TUBO cells | No immunological responses and antitumor effect | (188) |
78 | New Technologies | MUC1 antigen | USPIO-C595 | MCF-7, MDA-MB-231 and LNCap cell lines, BALB/c mice with MUC1-positive breast tumor | ↑ Uptake | (189) |
79 | New Technologies | | 2-aryl-3-nitro-2H-chromenes 4a-u,2-aryl-3-nitro-2H-chromenes 4 l | MCF-7 cell line | ↑Activity ,↑↑↑Activity compare with Etoposide | (190) |
2-aryl-3-nitro-2H-chromenes 4a,4b,4c,4d,4e,4f,4 g,4h,4j,4 k,4 l,4 m,4n,4o,4p,4r and 4 s | T-47D cell line | ↑Cytotoxicity compare with etoposide |
2-aryl-3-nitro-2H-chromenes 4a-u instead of 4i,2-aryl-3-nitro-2H-chromenes 4b | MDA-MB-231 cell line | ↑Activity, ↑↑Activity compare with Etoposide |
2-aryl-3-nitro-2H-chromenes 4 h and 4 l | MDA-MB-231 cell line | ↑Caspase-3 activity, ↓ Cell viability and cell growth, ↑apoptosis |
2-aryl-3-nitro-2H-chromenes 4 h and 4 l | MCF-7 cell line | ↓ Cell viability and cell growth, ↑apoptosis |
80 | New Technologies | IL-2 | pCDNA-2 hinge CAR-OX40 | MCF-7 and NIH3T3 cell line | ↑Expression | (191) |
pCDNA-2 hinge CAR and pCDNA-2 hinge CAR-OX40 | T-47D cell line | ↑Expression |
pCDNA3.1/HYGRO(+) | A-431 cell line | ↑Expression |
81 | Effect of Components | | lactobacillus acidophilus ATCC4356 strain | Female BALB/c mice | ↑proliferation of immune cells, ↑survival rate compare with control mice | (192) |
IFnγ | | | ↑Expression |
IL4 | | | ↓Expression |
82 | Immunotherapy-Immunology | | gp96N-terminal/Her2/GFP | Female BALB/c mice with TUBO cells | ↓ therapeutic potentials of Her2 DNA vaccine | (193) |
Ifnγ,IL4 | gp96N-terminal/Her2/GFP | TUBO cell-raised tumor extract | ↑ Proliferation compare with pHer2- or pCT/Her2-vaccinated animals |
CD4+/CD8+ | gp96N-terminal/Her2/GFP | TUBO cell-raised tumor extract | ↑Expression in the order of pNT/Her2 > pCT/Her2 > pHer2 |
82 | New Technologies | | GP96 + Her2/Her2 | Female BALB/c mice with TUBO cells | better in part I↑Growth rate of tumors, better in part II↑Growth rate of tumors, | (194) |
CD4 + CD25 + Foxp3+ | pHer2 + pGP96-vaccinated animals | ↓Expression |
Ifnγ,IL4 | pHer2 + pGP96 | ↑Induce response, ↑proliferation, ↑Expression |
| CD4+ | pHer2 + pGP96-vaccinated miceand pHer2-vaccinated mice | ↑Expression |
84 | Immunotherapy-Immunology | IL-4 | T7-phage nanoparticles | Female BALB/c mice (H-2d haplotype) with TUBO cells | ↑Expression compare with control | (195) |
IgG antibodies | T7-p66 Chimeric Nanoparticles | ↑Expression against T7 capsids in all T7 nanoparticle- immunized mice |
Ifnγ | T7-p66 Chimeric Nanoparticles | ↑Expression |
85 | New Technologies | | 2-amino-4-aryl-4H-benzo[h or f]chromene-3- carbonitrile 4 h and 4e | BT20 cell line | ↓ Cell proliferation | (196) |
Src kinase | 2-amino-4-aryl-4H-benzo[h or f]chromene-3- carbonitrile 4d, 4i, 4 m, and 4n | BT20 cell line | ↑ Inhibitory activity |
86 | Biomarkers | IGF-1, HGF,VEGF and IL-8 | | ASCs (Adipose derived stem cells) | ↑Expression | (197) |
87 | Biomarkers | IL-10 and TGF-b1 | | ASCs (Adipose derived stem cells) | Higher expressions | (198) |
IL-4, TGF-b1, IL-10, CCR4 and CD25 | PBLs (peripheral blood lymphocytes) |
88 | Immunotherapy-Immunology | | TSA-P1-24 and A-P1-15 | BT-20, BT-474, MDA-MB-361, MDA- MB-453, MDA-MB-468, MCF-7, T-47D, SK-BR-3, and Mel III cell lines | ↑ Immune response | (199) |
89 | Immunotherapy-Immunology (DNA VAccine) | Anti-HER2 antibody | fECD DNA | Female BALB/c mice | Induce anti Her2 antibody response | (200) |
HER2 DNA subdomains (DI, DII, DIII, and DIV) | |
| BT474 cell line |
90 | Immunotherapy-Immunology | | Tumoral ASCs | T cells | ↑ CD4 + CD25 + CD127LowFoxp3 + and CD4 + CD25-CD127LowFoxp3 + Treg subsets | (201) |
IL-4 and IL-10 | ↑Expression |
IFN-γ | ↓Expression |
91 | Immunotherapy-Immunology | | Radiation | | Higher chromatid radiosensitivity | (202) |
Radiation | lymphocytes | Higher background SCE |
92 | Radiosensitivity | | Radiation | leukocytes | higher apoptosis induction, DNA damage | (203) |
93 | Effect of Components | Bcl-2, procaspase3 and procaspase9 | Econazole Nitrate | MCF-7 cell line | ↓Expression | (204) |
94 | Effect of Components | | menadione | trastuzumab-sensitive SKBR3 cells | ↑level of ROS, ↓ level of GSH | (205) |
menadione + trastuzumab | trastuzumab-sensitive SKBR3 cells | no effect on ROS, ↓ level of GSH |
menadione | trastuzumab-resistant SKBR3 cells | ↓ level of ROS and GSH |
menadione + trastuzumab | trastuzumab-resistant SKBR3 cells | no effect on ROS, ↓ level of GSH |
95 | Immunotherapy-Immunology | | | | Higher CD8 + T cells frequency | (206) |
| | Lower frequency of CD4 + in macro-metastatic dLN than micro-metastatic dLN |
granzyme B | micro-metastatic dLN | Higher expression |
CXCL10 | | No difference |
96 | New Technologies | Dopamine Receptor D2 | Bromocriptine | MCF-7 CELLS | ↑ Apoptosis | (207) |
97 | Effect of Components | Adenosine Receptors | Adenosine | MDA-MB468 and MCF-7 cells | ↑ Cell growth | (208) |
98 | Effect of Components | cell growth | Zingiber | MCF-7 and L929 cells | Cytotoxic effects on tumor cells, Negative cytotoxic effect on normal cells | (209) |
99 | Biomarkers | mir145 | mir145 vector | MCF10A/MCF7 | ↑ expression levels of miR-145 in MCF10A | (210) |
100 | Effect of Components | RARB, BRCA1, RASSF1A | folate and other one-carbon related nutrients | 149 participants with primary breast cancer | ↑ Frequency of tumors with methylation status at RARB and BRCA1 genes. | (211) |
101 | Effect of Components | Telomerase Activity | Zinc, Selenium and Copper | T47D cells and 56 breast cancer patients | Paradoxical relationship between trace elements levels with telomerase activity in tumor tissue | (212) |
102 | Effect of Components | Cell Growth | LACTOBACILLUS RHAMNOSUS | INBRED BALB/C MICE | ↑ Immune system responses against tumor | (213) |
103 | Effect of Components | cell growth | Newcastle Disease Virus | MCF-7 cell line | oncolytic effect of NDV-AF2240 against the MCF-7cell line | (214) |
104 | Effect of Components | Tumor Mass Status, intra Tumor CD4/CD8 ratio of the mammary tumor | Candida Albicans Infections (Candidiasis) | Balb/C Mice | immunosuppressive effects of candida albicans on proliferation of lymphocytes | (215) |