1.
Claessens YE, Dhainaut JF. Diagnosis and treatment of severe sepsis. Critical care.
2007;11 Suppl 5:S2.
2.
Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. The Journal
of clinical investigation. 2012;122(8):2731-40.
3.
Sibbald WJ, Paterson NA, Holliday RL, Anderson RA, Lobb TR, Duff JH. Pulmonary hypertension
in sepsis: measurement by the pulmonary arterial diastolic-pulmonary wedge pressure
gradient and the influence of passive and active factors. Chest. 1978;73(5):583-91.
4.
Chan CM, Klinger JR. The right ventricle in sepsis. Clinics in chest medicine. 2008;29(4):661-76,
ix.
5.
Court O, Kumar A, Parrillo JE, Kumar A. Clinical review: Myocardial depression in
sepsis and septic shock. Critical care. 2002;6(6):500-8.
6.
Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, et al. A selective
inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic
dysfunction in endotoxemic mice. American journal of physiology Heart and circulatory
physiology. 2003;285(6):H2524-30.
7.
Clavijo LC, Carter MB, Matheson PJ, Wills-Frank LA, Wilson MA, Wead WB, et al. Platelet-activating
factor and bacteremia-induced pulmonary hypertension. The Journal of surgical research.
2000;88(2):173-80.
8.
Kleinsasser A, Loeckinger A, Hoermann C, Puehringer F, Mutz N, Bartsch G, et al. Sildenafil
modulates hemodynamics and pulmonary gas exchange. American journal of respiratory
and critical care medicine. 2001;163(2):339-43.
9.
Raja SG, Danton MD, MacArthur KJ, Pollock JC. Treatment of pulmonary arterial hypertension
with sildenafil: from pathophysiology to clinical evidence. Journal of cardiothoracic
and vascular anesthesia. 2006;20(5):722-35.
10.
Krebs J, Kolz A, Tsagogiorgas C, Pelosi P, Rocco PR, Luecke T. Effects of lipopolysaccharide-induced
inflammation on initial lung fibrosis during open-lung mechanical ventilation in rats.
Respiratory physiology & neurobiology. 2015;212-214:25-32.
11.
Wyns H, Plessers E, De Backer P, Meyer E, Croubels S. In vivo porcine lipopolysaccharide
inflammation models to study immunomodulation of drugs. Veterinary immunology and
immunopathology. 2015.
12.
Wheeler AP, Bernard GR. Acute lung injury and the acute respiratory distress syndrome:
a clinical review. Lancet. 2007;369(9572):1553-64.
13.
Wang HM, Bodenstein M, Markstaller K. Overview of the pathology of three widely used
animal models of acute lung injury. European surgical research Europaische chirurgische
Forschung Recherches chirurgicales europeennes. 2008;40(4):305-16.
14.
Griffee MJ, Merkel MJ, Wei KS. The role of echocardiography in hemodynamic assessment
of septic shock. Critical care clinics. 2010;26(2):365-82, table of contents.
15.
Furian T, Aguiar C, Prado K, Ribeiro RV, Becker L, Martinelli N, et al. Ventricular
dysfunction and dilation in severe sepsis and septic shock: relation to endothelial
function and mortality. Journal of critical care. 2012;27(3):319 e9-15.
16.
Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V, et al. Clinical
spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and
septic shock. Mayo Clinic proceedings. 2012;87(7):620-8.
17.
Orde SR, Pulido JN, Masaki M, Gillespie S, Spoon JN, Kane GC, et al. Outcome prediction
in sepsis: speckle tracking echocardiography based assessment of myocardial function.
Critical care. 2014;18(4):R149.
18.
Harmankaya A, Akilli H, Gul M, Akilli NB, Ergin M, Aribas A, et al. Assessment of
right ventricular functions in patients with sepsis, severe sepsis and septic shock
and its prognostic importance: a tissue Doppler study. Journal of critical care. 2013;28(6):1111
e7- e11.
19.
Haase E, Bigam DL, Cravetchi O, Cheung PY. Dose response of intravenous sildenafil
on systemic and regional hemodynamics in hypoxic neonatal piglets. Shock. 2006;26(1):99-106.
20.
Bhatia S, Frantz RP, Severson CJ, Durst LA, McGoon MD. Immediate and long-term hemodynamic
and clinical effects of sildenafil in patients with pulmonary arterial hypertension
receiving vasodilator therapy. Mayo Clinic proceedings. 2003;78(10):1207-13.
21.
Kloner RA. Novel phosphodiesterase type 5 inhibitors: assessing hemodynamic effects
and safety parameters. Clinical cardiology. 2004;27(4 Suppl 1):I20-5.
22.
Ryhammer PK, Shekerdemian LS, Penny DJ, Ravn HB. Effect of intravenous sildenafil
on pulmonary hemodynamics and gas exchange in the presence and absence of acute lung
injury in piglets. Pediatric research. 2006;59(6):762-6.
23.
Ghofrani HA, Wiedemann R, Rose F, Schermuly RT, Olschewski H, Weissmann N, et al.
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised
controlled trial. Lancet. 2002;360(9337):895-900.
24.
Cadirci E, Halici Z, Odabasoglu F, Albayrak A, Karakus E, Unal D, et al. Sildenafil
treatment attenuates lung and kidney injury due to overproduction of oxidant activity
in a rat model of sepsis: a biochemical and histopathological study. Clinical and
experimental immunology. 2011;166(3):374-84.
25.
Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, et al. Detection
of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies
a subgroup at higher risk of adverse outcomes. Journal of cardiac failure. 2014;20(1):31-7.
26.
Naidech AM, Bassin SL, Garg RK, Ault ML, Bendok BR, Batjer HH, et al. Cardiac troponin
I and acute lung injury after subarachnoid hemorrhage. Neurocritical care. 2009;11(2):177-82.
27.
Bajwa EK, Boyce PD, Januzzi JL, Gong MN, Thompson BT, Christiani DC. Biomarker evidence
of myocardial cell injury is associated with mortality in acute respiratory distress
syndrome. Critical care medicine. 2007;35(11):2484-90.
28.
Heresi GA, Tang WH, Aytekin M, Hammel J, Hazen SL, Dweik RA. Sensitive cardiac troponin
I predicts poor outcomes in pulmonary arterial hypertension. The European respiratory
journal. 2012;39(4):939-44.
29.
Hassan MA, Ketat AF. Sildenafil citrate increases myocardial cGMP content in rat heart,
decreases its hypertrophic response to isoproterenol and decreases myocardial leak
of creatine kinase and troponin T. BMC pharmacology. 2005;5:10.
30.
Kiss T, Kovacs K, Komocsi A, Tornyos A, Zalan P, Sumegi B, et al. Novel mechanisms
of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases
and Akt. PloS one. 2014;9(8):e104890.