Shelling is a central and crucial step in the mechanized processing of scallops. However, current research on the peeling mechanism is insufficient, and a relatively complete theoretical system has not been established so far. This paper proposes an application of response surface methodology and the design of an experiment to provide and stimulate further research on the automation of scallop shucking. Effective factors on the binding force of scallops are evaluated and discussed in this paper. The relationship between responses with significant factors is established. By employing response surface methodology, mathematical regression model can be efficiently performed. This response model is applied to analyze the response surface contours and surface plots to estimate shelling performance by developing a better shucking process. At the same time, quadric model proposed is used not only for predicted optimal process parameters but also for process optimization, and enrich the theoretical system of shellfish shelling.