Table 1. Baseline CBC results for subsequent IGRA converters and IGRA-negative participants.
IGRA- All Early Late Transient Persistent
Negative Converters Converters Converters Converters Converters
(n=98) (n=47) (n=18) (n=29) (n=25) (n=22)
Laboratory Component Mean Mean p-val Mean p-val Mean p-val Mean p-val Mean p-val
(S.D.) (S.D.) (S.D.) (S.D.) (S.D.) (S.D.)
White blood cells (WBCs)
WBC count (× 103/mcL) 6.14 5.81 0.20 5.79 0.46 5.82 0.24 5.79 0.36 5.83 0.29
(1.36) (1.36) (1.22) (1.47) (1.43) (1.32)
1Neutrophil count (× 103/mcL) 2.66 2.26 0.06 2.34 0.29 2.22 0.08 2.37 0.36 2.15 0.05
(0.96) (0.93) (0.94) (0.94) (1.00) (0.85)
Neutrophil % 42.5 38.2 0.11 39.6 0.41 37.4 0.12 39.4 0.48 36.8 0.07
(8.6) (11.8) (11.2) (12.2) (11.1) (12.6)
Lymphocyte count (× 103/mcL) 2.68 2.73 0.91 2.66 0.94 2.78 0.92 2.66 0.96 2.82 0.90
(0.56) (0.74) (0.63) (0.81) (0.61) (0.87)
Lymphocyte % 44.5 47.8 0.12 46.5 0.51 48.6 0.11 47.2 0.39 48.5 0.11
(7.6) (10.0) (9.2) (10.5) (9.6) (10.5)
Monocyte count (× 103/mcL) 0.484 0.459 0.40 0.467 0.99 0.454 0.26 0.425 0.10 0.498 0.68
(0.151) (0.175) (0.153) (0.189) (0.147) (0.197)
Monocyte % 7.9 7.9 0.61 8.0 0.92 7.8 0.44 7.3 0.18 8.5 0.52
(2.0) (2.5) (2.2) (2.7) (1.6) (3.1)
Eosinophil count (× 103/mcL) 0.220 0.253 0.26 0.230 0.88 0.268 0.16 0.249 0.17 0.258 0.75
(0.259) (0.229) (0.222) (0.236) (0.197) (0.266)
Eosinophil % 3.5 4.4 0.17 4.2 0.80 4.5 0.09 4.5 0.13 4.3 0.58
(3.6) (3.9) (4.4) (3.6) (4.0) (3.8)
Basophil count (× 103/mcL) 0.100 0.097 0.98 0.093 0.66 0.100 0.77 0.084 0.90 0.112 0.93
(0.075) (0.068) (0.069) (0.069) (0.036) (0.091)
Basophil % 1.6 1.7 0.60 1.7 0.99 1.7 0.46 1.5 0.69 1.9 0.68
(1.1) (1.2) (1.4) (1.2) (0.8) (1.6)
Red blood cells (RBCs)
1,2RBC count (× 106/mcL) 4.8 4.6 0.008 4.7 0.20 4.5 0.008 4.7 0.08 4.5 0.02
(0.4) (0.5) (0.8) (0.4) (0.6) (0.4)
1,2Hemoglobin (g/dL) 12.6 12.3 0.01 12.5 0.08 12.1 0.03 12.4 0.09 12.1 0.02
(1.0) (1.6) (2.4) (0.9) (2.0) (1.0)
1,2,3,4Hematocrit (%) 38.8 37.8 0.005 38.2 0.03 37.5 0.03 38.1 0.04 37.4 0.02
(3.0) (4.5) (6.5) (2.7) (5.6) (3.0)
MCV (fL) 81.9 82.2 0.67 81.4 0.90 82.7 0.50 81.4 0.68 83.1 0.26
(6.2) (5.7) (6.7) (5.1) (5.2) (6.3)
MCH (pg) 26.5 26.8 0.50 26.7 0.58 26.8 0.62 26.6 0.96 27.0 0.30
(2.2) (2.1) (2.5) (1.9) (2.1) (2.2)
MCHC (g/dL) 32.4 32.5 0.36 32.8 0.12 32.4 0.94 32.6 0.31 32.5 0.71
(0.9) (0.9) (0.8) (1.9) (0.9) (1.0)
RDW (%) 16.1 16.7 0.33 16.9 0.38 16.6 0.51 17.2 0.15 16.1 0.99
(1.5) (2.4) (2.9) (2.2) (3.0) (1.5)
Platelets
Platelet count (× 103/mcL) 312 300 0.20 306 0.24 297 0.38 288 0.19 315 0.51
(103) (118) (141) (104) (107) (131)
S.D.: standard deviation; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width.
Table 2. Baseline MLR, NLR, and PLR for subsequent IGRA converters and IGRA-negative participants.
Group n Mean S.D. Q1 Q3 p-value
MLR
IGRA Negatives 98 0.18 0.05 0.15 0.21 Reference
All Converters 47 0.17 0.06 0.13 0.20 0.10
Early Converters 18 0.18 0.07 0.13 0.22 0.56
Late Converters 29 0.16 0.06 0.13 0.18 0.07
Transient Converters 25 0.16 0.04 0.13 0.18 0.03
Persistent Converters 22 0.18 0.08 0.14 0.22 0.73
NLR
IGRA Negatives 98 1.02 0.40 0.74 1.22 Reference
All Converters 47 0.88 0.42 0.56 1.21 0.08
Early Converters 18 0.93 0.42 0.62 1.25 0.35
Late Converters 29 0.85 0.42 0.50 1.20 0.09
Transient Converters 25 0.91 0.39 0.68 1.69 0.38
Persistent Converters 22 0.85 0.45 0.48 1.10 0.06
PLR
IGRA Negatives 98 120 46 96 135 Reference
All Converters 47 115 50 82 152 0.28
Early Converters 18 119 58 89 136 0.41
Late Converters 29 113 45 80 158 0.40
Transient Converters 25 112 43 79 155 0.22
Persistent Converters 22 119 57 87 142 0.69
S.D.: standard deviation; Q1: first quartile (25th percentile); Q3: third quartile (75th percentile).
Table 3. Concurrent CBC results and CBC-derived ratios for early and late converters at first study visit where IGRA conversion was detected versus time-matched controls.
Early Negatives Late Negatives
Converters at Day 60 Converters at Day 720 p-value p-value p-value
Laboratory Mean Mean Mean Mean (EC vs (LC vs (EC vs
Component (S.D.) (S.D.) (S.D.) (S.D.) N60) N720) LC)
White blood cells (WBCs)
WBC count1 5.62 (1.18) 5.52 (1.44) 5.86 (1.48) 5.43 (1.42) 0.53 0.13 0.48
Neutrophil count1 2.16 (0.85) 2.27 (1.12) 2.62 (1.24) 2.28 (1.02) 0.92 0.24 0.31
Neutrophil % 37.5 (11.1) 39.3 (10.7) 43.2 (12.6) 41.2 (12.0) 0.57 0.75 0.24
Lymphocyte count1 2.69 (0.54) 2.53 (0.63) 2.53 (0.71) 2.41 (0.71) 0.33 0.45 0.40
Lymphocyte % 48.8 (7.6) 47.0 (9.4) 44.4 (11.5) 45.0 (9.6) 0.50 0.81 0.15
Monocyte count1 0.405 (0.147) 0.428 (0.204) 0.374 (0.158) 0.448 (0.365) 0.77 0.33 0.42
Monocyte % 7.2 (2.1) 7.9 (3.9) 6.5 (2.5) 8.4 (7.0) 0.64 0.09 0.30
Eosinophil count1 0.185 (0.205) 0.177 (0.209) 0.269 (0.281) 0.163 (0.224) 0.84 0.13 0.28
Eosinophil % 3.3 (3.7) 3.1 (3.3) 4.6 (4.8) 3.0 (3.5) 0.66 0.17 0.29
Basophil count1 0.181 (0.292) 0.123 (0.116) 0.071 (0.040) 0.143 (0.201) 0.62 0.46 0.42
Basophil % 3.2 (4.7) 2.4 (2.6) 1.3 (0.9) 2.6 (3.4) 0.55 0.07 0.24
Red blood cells (RBCs)
RBC count2 4.6 (0.6) 4.7 (0.5) 4.7 (0.5) 4.8 (0.5) 0.53 0.68 0.44
Hemoglobin (g/dL) 12.1 (1.4) 12.3 (1.0) 13.0 (1.4) 12.7 (1.3) 0.29 0.42 0.04
Hematocrit (%) 37.7 (4.5) 38.5 (3.3) 40.8 (4.8) 40.1 (4.1) 0.22 0.50 0.05
MCV (fL) 82.3 (6.1) 82.7 (6.7) 86.0 (4.7) 84.0 (7.0) 0.90 0.27 0.04
MCH (pg) 26.5 (2.2) 26.6 (2.8) 27.4 (1.8) 26.7 (2.5) 0.98 0.17 0.14
MCHC (g/dL) 32.2 (1.0) 32.1 (2.1) 31.9 (1.5) 31.8 (1.4) 0.78 0.35 0.68
RDW (%) 17.1 (2.1) 16.6 (1.5) 16.4 (1.6) 16.8 (2.1) 0.57 0.64 0.38
Platelets
Platelet count1 276 (81) 311 (168) 272 (95) 289 (79) 0.32 0.37 0.93
CBC-derived Ratios
MLR 0.15 (0.05) 0.18 (0.10) 0.16 (0.07) 0.20 (0.25) 0.54 0.20 0.88
NLR 0.82 (0.38) 0.94 (0.57) 1.13 (0.69) 1.01 (0.54) 0.45 0.71 0.15
PLR 105 (32) 138 (132) 114 (46) 128 (43) 0.11 0.21 0.53
EC: early converters; N60; IGRA-negative at day 60 (time-matched controls for early converters); LC: late converters; N720: IGRA-negative at day 720 (time-matched controls for late converters); MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; 1: units are × 103/mcL; 2: units are × 106/mcL.