1.Danisovic L, Varga I, Zamborsky R, Böhmer D. The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors. Exp Biol Med (Maywood). 2012;237(1):10-7. PMID: 22156044 DOI: 10.1258/ebm.2011.011229
2.Goepfert C, Slobodianski A. Schilling AF, Adamietz P, Pörtner R. Cartilage engineering from mesenchymal stem cells. Adv Biochem Eng Biotechnol. 2010;123:163-200. PMID: 20535603 DOI: 10.1007/10_2010_67
3.Henson FM, Getgood AM, Caborn DM, McIlwraith CW, Rushton N.Effect of a solution of hyaluronic acid-chondroitin sulfate-N- acetyl glucosamine on the repair response of cartilage to single-impact load damage. Am J Vet Res. 2012;73(2):306-12. PMID: 22280395 DOI: 10.2460/ajvr.73.2.306
4.Buckley CT, Meyer EG, Kelly DJ. The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells.Tissue Eng Part A. 2012;18(3-4):382-96. PMID: 21919793 DOI: 10.1089/ten.TEA.2011.0145
5.Kang SW, Yoo SP, Kim BS. Effect of chondrocyte passage number on histological aspects of tissue-engineered cartilage. Biomed Mater Eng. 2007;17(5):269-76. PMID: 17851169
6.Poole, CA, Ayad S, Gilbert RT. Chondrons from articular cartilage. V. Immunohistochemical evaluation of type VI collagen organisation in isolated chondrons by light, confocal and electron microscopy. J Cell Sci. 1992;103 ( Pt 4): 1101-10. PMID: 1487492
7.Poole CA. Articular cartilage chondrons: Form, function and failure. J Anat. 1997;191(1):1-13. PMID: 9279653 DOI: 10.1046/j.1469-7580.1997.19110001.x
8.Choi JB, Youn I, Cao L, Leddy HA, Gilchrist CL, Setton LA, Guilak F. Zonal changes in the three- dimensional morphology of the chondron under compression: The relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J Biomech. 2007;40(12): 2596-603. PMID: 17397851 DOI: 10.1016/j.jbiomech.2007.01.009
9.Guilak, F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann N Y Acad Sci.2006; 1068: 498-512. PMID: 16831947 DOI: 10.1196/annals.1346.011
10.Alexopoulos LG, Setton LA, Guilak F. The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomater. 2005;1(3):317-25. PMID: 16701810 DOI: 10.1016/j.actbio.2005.02.001
11.Felka, T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology. Osteoarthritis Cartilage. 2016;24(7): 1200-9. PMID: 26879798 DOI: 10.1016/j.joca.2016.02.001
12.Youn I, Choi JB, Cao L, Setton LA, Guilak F. Zonal variations in the three- dimensional morphology of the chondron measured in situ using confocal microscopy. Osteoarthritis Cartilage. 2006;14(9):889-97. PMID: 16626979 DOI: 10.1016/j.joca.2006.02.017
13.Hing, WA, Sherwin AF, Poole CA. The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge. Osteoarthritis Cartilage. 2002;10(4): 297-307. PMID: 11950253 DOI: 10.1053/joca.2002.0517
14.Larson, CM, Kelley SS, Blackwood AD, Banes AJ, Lee GM. Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. Matrix Biol. 2002;21(4): 349-59. PMID: 12128072 DOI: 10.1016/s0945-053x(02)00026-4
15.Peters HC, Otto TJ, Enders JT, Jin W, Moed BR, Zhang Z. The protective role of the pericellular matrix in chondrocyte apoptosis. Tissue Eng Part A. 2011;17(15-16): 2017-24. PMID: 21457093 DOI: 10.1089/ten.TEA.2010.0601
16.Alexopoulos LG, Haider MA, Vail TP, Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng. 2003;125(3):323-33. PMID: 12929236 DOI: 10.1115/1.1579047
17.Nguyen BV, Wang QG, Kuiper NJ, El Haj AJ, Thomas CR, Zhang Z. Biomechanical properties of single chondrocytes and chondrons determined by micromanipulation and finite-element modeling. J R Soc Interface. 2010;7(53): 1723-33. PMID: 20519215 DOI: 10.1098/rsif.2010.0207
18.Lee GM, Poole CA, Kelley SS, Chang J, Caterson B. Isolated chondrons: A viable alternative for studies of chondrocyte metabolism in virto. Ostooarthritis Cartilage. 1997; 5(4): 261-74. PMID: 9404471 DOI: 10.1016/s1063-4584(97)80022-2
- Duan W, Wei L, Zhang J, Hao Y, Li C, Li H, Li Q, Zhang Q, Chen W, Wei X. Alteration of viscoelastic properties is associated with a change in cytoskeleton components of ageing chondrocytes from rabbit knee articular cartilage. Mol Cell Biomech. 2011;8(4):253-74. PMID: 22338706
- Duan WP, Sun ZW, Li Q, Li CJ, Wang L, Chen WY, Tickner J, Zheng MH, Wei XC. Normal age-related viscoelastic properties of chondrons and chondrocytes isolated from rabbitknee. Chin Med J (Engl). 2012;125(14):2574-81. PMID: 22882942
- Chubinskaya S, Hakimiyan A, Pacione C, Yanke A, Rappoport L, Aigner T, Rueger DC, Loeser RF. Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads. Osteoarthritis Cartilage. 2007, 15(4): 421-30. PMID: 17126570 DOI: 10.1016/j.joca.2006.10.004
- Khoshfetrat AB, Kino-oka M, Takezawa Y, Sato Y, Yamamoto T, Sugawara K, Taya M. Effect of transforming growth factor-β1 on morphological characteristics relating to migration and differentiation of rabbit chondrocytes cultured in collagen gels. J Biosci Bioeng. 2008, 106(6): 547-53. PMID: 19134549 DOI: 10.1263/jbb.106.547
- Connelly JT, Wilson CG, Levenston ME. Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs. Osteoarthritis Cartilage. 2008;16(9):1092-100. PMID: 18294870 DOI: 10.1016/j.joca.2008.01.004
- Dimicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes. Osteoarthritis Cartilage. 2007;15(10):1207-16. PMID: 17524677 DOI: 10.1016/j.joca.2007.03.023
- Björnsson S. Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue. Anal Biochem.1993;210(1): 282-91. PMID: 8512063 DOI: 10.1006/abio.1993.1197
- Wang X, Li F, Fan C, Wang C, Ruan H. Effects and relationship of ERK1 and ERK2 in interleukin-1β-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes. Int J Mol Med. 2011;27(4): 583-9. PMID: 21305249 DOI: 10.3892/ijmm.2011.611
- Saleh MA, Ishii K, Kim YJ, Murakami A, Ishii N, Hashimoto T, Schmidt E, Zillikens D, Shirakata Y, Hashimoto K, Kitajima Y, Amagai M. Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients. J Dermatol Sci 2011;62(3): 169-75. PMID: 21482078 DOI: 10.1016/j.jdermsci.2011.03.003
- Qian W, Jin F, Zhao Y, Chen Y, Ge L, Liu L, Yang M. Downregulation of microRNA-144 inhibits proliferation and promotes the apoptosis of myelodysplastic syndrome cells through the activation of the AKAP12-dependent ERK1/2 signaling pathway. Cell Signal. 2019;68:109493. PMID: 31809872 DOI: 10.1016/j.cellsig.2019.109493
- Duan W, Wei L, Cao X, Guo H, Wang L, Hao Y, Wei X. Effect of the disruption of three cytoskeleton components on chondrocyte metabolism in rabbit knee cartilage. Chin Med J (Engl). 2014,127(21):3764-70.PMID: 25382333.
30.Madry H, Cucchiarini M, Stein U, Remberger K, Menger MD, Kohn D, Trippel SB. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med. 2003; 5(6): 502-9. PMID:12797115. DOI: 10.1002/jgm.368.
31.Numata H, Nakase J, Oshima T, Tsuchiya H. Effectiveness of adhering adipose-derived stem cells to defective cartilage in promoting cartilage regeneration in a rabbit model. Arthroscopy. 2019;35(9):2619-26. PMID: 31307837 doi: 10.1016/j.arthro.2019.03.018.
32.Kosaka M, Nakase J, Hayashi K, Tsuchiya H. Adiposederived regenerative cells promote tendon-bone healing in a rabbit model. Arthroscopy. 2016;32(5):851-9. PMID: 26790583 DOI: 10.1016/j.arthro.2015.10.012
33.Rothdiener M, Uynuk-Ool T, Südkamp N, Aurich M, Grodzinsky AJ, Kurz B, Rolauffs B. Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair? J Tissue Eng Regen Med. 2018;12(2):1206-20. PMID: 28714570 DOI: 10.1002/term.2516
34.Bonarentue J, Kadhom N, Cohen-solal L, Ng KH, Bourguignon J, Lasselin C, Freisinger P. Reexpression of cartilage-specific genes by dedifferentialted human articular chondrocytes cultures in alginate beads. Exp Cell Res. 1993;212(1):97-104. PMID: 8174647 DOI: 10.1006/excr.1994.1123
35.Nguyen BV, Wang QG, Kuiper NJ, El Haj AJ, Thomas CR, Zhang Z. Strain-dependent viscoelastic behaviour and rupture force of single chondrocytes and chondrons under compression. Biotechnol Lett. 2009;31(6):803-9. PMID: 19205892 DOI: 10.1007/s10529-009-9939-y
36.Kvist AJ, Nyström A, Hultenby K, Sasaki T, Talts JF, Aspberg A. The major basement membrane components localize to the chondrocyt pericellular matrix: A cartilage basement membrane equivalent? Matrix Biol.2008;27(1):22-33. PMID: 17825545 DOI: 10.1016/j.matbio.2007.07.007
37.Ofek G, Natoli RM, Athanasiou KA. In situ mechanical properties of the chondrocyte cytoplasm and nucleus. J Biomech.2009;42(7):873–7. PMID: 19261283 DOI: 10.1016/j.jbiomech.2009.01.024
38.Ofek G, Wiltz DC, Athanasiou KA. Contributionof the cytoskeleton to the compressive properties and recovery behavior of single cells. Biophys J.2009;97(7):1873–82. PMID: 19804717 DOI: 10.1016/j.bpj.2009.07.050
39.Vonk LA, Doulabi BZ, Huang C, Helder MN, Everts V, Bank RA. Preservation of the chondrocyte's pericellular matrix improves cell-induced cartilage formation. J Cell Biochem. 2010;110(1):260-71. PMID: 20213765 DOI: 10.1002/jcb.22533
40.Nikpou P, Nejad DM, Shafaei H, Roshangar L, Samadi N, Navali AM, Sadegpour AR, Shanehbandi D, Rad JS. Study of chondrogenic potential of stem cells in co-culture with chondrons. Iran J Basic Med Sci. 2016;19(6):638-45. PMID: 27482345 PMCID: PMC4951603
41.Zhang Z, Fan JF, Becker KG, Graff RD, Lee GM, Francomano CA. Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray study. Osteoarthritis Cartilage. 2006; 14(5):449-59. PMID: 16414292 DOI: 10.1016/j.joca.2005.11.008
42.Wang QG, Magnay JL, Nguyen B, Thomas CR, Zhang Z, El Haj AJ, El Haj AJ, Kuiper NJ. Gene expression profiles of dynamically compressed single chondrocytes and chondrons. Biochem Biophys Res Commun. 2009; 379(3):738-42. PMID: 19118531 DOI: 10.1016/j.bbrc.2008.12.111
43.Shieh AC, Athanasiou KA. Dynamic compression of single cells. Osteoarthritis Cartilage. 2007; 15(3):328-34. PMID: 17045815 DOI: 10.1016/j.joca.2006.08.013
44.Vonk LA, Doulabi BZ, Huang C, Helder MN, Everts V, Bank RA. Preservation of the chondrocyte's pericellular matrix improves cell-induced cartilage formation. J Cell Biochem.2010;110(1):260-71. PMID: 20213765 DOI: 10.1002/jcb.22533
45.Farnsworth N, Bensard C, Bryant SJ. The role of the PCM in reducing oxidative stress induced by radical initiated photoencapsulation of chondrocytes in poly(ethylene glycol) hydrogels. Osteoarthritis. Cartilage.2012;20(11):1326-35. PMID: 22796510 DOI: 10.1016/j.joca.2012.06.015
46.Graff RD, Kelley SS, Lee GM. Role of pericellular matrix in development of a mechanically functional neocartilage. Biotechnol Bioeng. 2003;82(4):457-64. PMID: 12632402 DOI: 10.1002/bit.10593
47.Julkunen P, Wilson W, Jurvelin JS, Korhonen RK.Composition of the pericellular matrix modulates the deformation behaviour of chondrocytes in articular cartilage under static loading. Med Biol Eng Comput.2009;47(12):1281-90. PMID: 19898885 DOI: 10.1007/s11517-009-0547-8
48.Murray DH, Bush PG, Brenkel IJ, Hall AC. Abnormal human chondrocyte morphology is related to increased levels of cell-associated IL-1b and disruption to pericellular collagen type VI. J Orthop Res.2010;28(11):1507–14. PMID: 20872589 DOI: 10.1002/jor.21155
49.Bekkers JE, Tsuchida AI, van Rijen MH, Vonk LA, Dhert WJ, Creemers LB, Saris DB. Single-stage cell-based cartilage regeneration using a combination of chondrons and mesenchymal stromal cells: comparison with microfracture. Am J Sports Med. 2013;41(9):2158-66. PMID: 23831891 DOI: 10.1177/0363546513494181
50.Owida HA, De Las Heras Ruiz T, Dhillon A, Yang Y, Kuiper NJ. Co-culture of chondrons and mesenchymal stromal cells reduces the loss of collagen VI and improves extracellular matrix production. Histochem Cell Biol. 2017;148(6):625-38. PMID: 28821957 doi: 10.1007/s00418-017-1602-4.
51.de Windt TS, Vonk LA, Slaper-Cortenbach IC, van den Broek MP, Nizak R, van Rijen MH, de Weger RA, Dhert WJ, Saris DB. Allogeneic mesenchymal stem cells stimulate cartilage regeneration and are safe for single-stage cartilage repair in humans upon mixture with recycled autologous chondrons. Stem Cells. 2017; 35(1):256-64. PMID: 27507787 DOI: 10.1002/stem.2475
52.Jacer S, Shafaei H, Soleimani Rad J. An investigation on the regenerative effects of intra articular injection of co-cultured adipose derived stem cells with chondron for treatment of induced osteoarthritis. Adv Pharm Bull. 2018;8(2):297-306. PMID: 30023332 doi: 10.15171/apb.2018.035
53.Mo XT, Guo SC, Xie HQ, Deng L, Zhi W, Xiang Z, Li XQ, Yang ZMl. Variations in the ratios of co-cultured mesenchymal stem cells and chondrocytes regulate the expression of cartilaginous and osseousphenotype in alginate constructs. Bone. 2009;45(1):42-51. PMID: 18708174 DOI: 10.1016/j.bone.2008.07.240