Titanium alloys are the difficult to cut metals due to their low thermal conductivity and chemical affinity with tool material. Since the tool vibration is a replica of tool wear and surface roughness, the present study has proposed a methodology for estimating tool wear and surface roughness based on tool vibration for milling of Ti-6Al-4V alloy using cemented carbide mill cutter. Experiments are conducted at optimum levels of cutting speed, feed per tooth and depth of cut and experimental results for the tool vibration, tool wear and surface roughness are collected until the flank wear reached 0.3 mm (ISO3685:1993). In the next stage, an optimization model of grey prediction GM(1,N) system and support vector machine (SVM) are used and estimated tool wear and surface roughness related to tool vibration. The predicted values of tool wear and surface roughness are compared with the experimental results. The optimization model of GM(1,N) predicted the tool wear and surface roughness with an average error of 3.03% and as 0.7% respectively while the SVM predicted with an average error of 7.67% and 4.45% respectively.