Through the search strategy, we could identify 42 articles about neurological involvement by COVID-19. We were able to identify 82 cases of COVID-19 with neurological complications. The mean age was 62.28 years (22-91). 37.8% of the patients were women (n = 31). All patients except 2 had positive nasopharyngeal (NP) or oropharyngeal (OP) SARS-CoV-2 RT-PCR swabs. Only 2 patients had positive CSF SARS-CoV-2 RT-PCR, one of which showed negative NP swab testing. 48.8 % of patients (n=40) had cerebrovascular insults (CVIs), 28% (n=23) had neuromuscular disorders (NMDs), 18.3 % (n=15) developed CNS complications related to infection or inflammation, 2.4% (n=2) presented with status epilepticus and 1.2 % (n=1) had CNS demyelinating lesions. 32.9% of patients (n=27) were recovering, 18.3% (n=15) had good outcome, 25.6 % (n=21) had poor outcome and 18.3% (n=15) died. One patient showed postmortem evidence of the presence of viral particles in the neurons and capillary endothelial cells in the frontal lobe (Table 1). In 23.2 % of patients (n=19), the neurologic syndrome was the initial presentation of COVID-19. Four of which, they developed respiratory symptoms 2-8 days after the onset of neurologic syndrome. In 2 patients the neurologic syndrome proceeded by 2-3 days of GI symptoms, while in 2 other patients, it was proceeded only by anosmia and dysgeusia. [Figure 2].
<table style="float: left;width:602.75pt;border-collapse:collapse;border:none;margin-left:6.75pt;margin-right:6.75pt;">
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Author, Year</strong></span></span></span></p>
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<td rowspan="2" style="width: 42.9pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 0.35in;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Age(y), Sex</strong></span></span></span></p>
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<td colspan="3" style="width: 71.9pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 0.35in;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>SARS-CoV-2</strong></span></span></span></p>
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<td rowspan="2" style="width: 1.65in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 0.35in;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Neurological Presentation</strong></span></span></span></p>
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<td rowspan="2" style="width: 123.2pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 0.35in;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Neurological Investigations (Images, EMG, EEG</strong>, <strong>autopsy)</strong></span></span></span></p>
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<td rowspan="2" style="width: 89.25pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 0.35in;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Neurological</strong></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>Diagnosis</strong></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong>CSF &</strong> <strong>Others</strong></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Nasal</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Swab</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF</span></span></span></p>
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<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 47.35pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Poyiadji et al. 2020 [10]</em></strong><strong><em>c</em></strong></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">58, F</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Altered mental status (AMS)</span></span></span></p>
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<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 47.35pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">MRI: Hemorrhagic rim enhancing lesions within the bilateral thalami, medial temporal lobes, and subinsular regions</span></span></span></p>
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<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 47.35pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Acute Hemorrhagic Necrotizing Encephalopathy</span></span></span></p>
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<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 47.35pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF was negative for HSV 1 & 2, VZV and West Nile PCRs</span></span></span></p>
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<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Moriguchi et al. 2020 [11] </em></strong><strong>#</strong></span></span></span></p>
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<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">24, M</span></span></span></p>
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<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
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<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
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<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Headache then unconsciousness, generalized convulsions and neck rigidity</span></span></span></p>
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<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">T2WI/FLAIR: hyperintensity</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">in the right mesial temporal lobe and hippocampus</span></span></span></p>
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<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Meningitis/Encephalitis </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Ventriculitis </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
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<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 48.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: OP >32 cmH<sub>2</sub>O, 12 mononuclear cells, 2 PMNs, CSF HSV1 PCR was not tested</span></span></span></p>
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<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Duong et al & Haung et al. 2020 [12&13] </em></strong><strong><em>*</em></strong></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">41, F</span></span></span></p>
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<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
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<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
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<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Headache, new onset seizure, neck stiffness, fever and photophobia</span></span></span></p>
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<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT head was normal </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EEG: Generalized slowing with no epileptic discharges</span></span></span></p>
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<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 53.2pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Meningoencephalitis</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 100 mg/dl. WBCs <span style="background:white;"> </span>70 cells/μL 100% lymphocyte. Glucose 120</span></span></span></p>
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<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Ye et al. 2020 [14] </em></strong><strong><em>**</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">No age, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Myalgia and confusion. Nuchal rigidity, positive Kernig sign and Brudzinski sign</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT head was normal</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Encephalitis</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.15pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: OP 220 mmHg. Normal WBC, protein and glucose</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Yin et al. 2020 [15] </em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">64, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">AMS, neck stiffness. Positive clonus, Babinski,<span style="background: white;"> </span>Chaddock and Brudzinski signs </span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT head was normal </span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Encephalitis</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: OP 200 cmH<sub>2</sub>O. protein, WBCs and glucose were normal</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Filatov et al. 2020 [16] </em></strong><strong><em>R</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">74, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Headache and AMS</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">EEG: bilateral slowing and focal slowing in the left temporal region with sharply contoured waves</span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Encephalopathy</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 43.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:107%;margin:0in;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 68 mg/dl. WBCs 4 cells/μL. </span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Wong et al. 2020 [17] </em></strong><strong><em>***</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">40, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Ataxia, diplopia, oscillopsia, hiccups, right arm paresthesia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">MRI: T2 hyperintensity of the right inferior cerebellar peduncle and upper cord associated with microhemorrhages</span></span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Rhombencephalitis</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CSF: normal WBC, protein and glucose</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Zhao et al. 2020 [18]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">61, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Legs & arms weakness.</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Areflexia</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Day 5 EMG/NCS revealed demyelinating pattern</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> 124 mg/dl. Cell counts 5 cells/μL</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Sedaghat et al. 2020 [19]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">65, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Ascending quadriparesis. B<span style="background: white;">ifacial nerve palsy. </span>Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Day 9 EMG/NCS revealed axonal pattern</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS variant - AMSAN</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.3pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CSF was not performed</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Virani et al. 2020 [20]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">54, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Ascending weakness and </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Paresthesia. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">T& L spine MRI was normal. </span>EMG/NCS were not performed</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 26.65pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF was not performed</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>El-Otmani et al. 2020 [21]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">70, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Quadriplegia. Hypotonia. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Day 10 </span>EMG/NCS revealed axonal pattern </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS variant - AMSAN</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 100 mg/dl. Normal WBC</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Alberti et al. 2020 [22]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">71, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Ascending weakness and paresthesia. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EMG/NCS revealed mixed axonal and demyelinating patterns</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS - mixed damage</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein <span style="background: white;">54</span> mg/dL. WBCs <span style="background: white;"> </span>9 cells/μL</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Camdessanche%20JP%5BAuthor%5D&cauthor=true&cauthor_uid=32334841"><em>Camdessanche</em></a></strong><strong><em> et al. 2020 [23]</em></strong><strong><em>Q</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">64, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Flaccid tetraparesia and paresthesia. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Day 5 </span>EMG/NCS revealed demyelinating pattern</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 28.45pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 166 mg/dl. Normal WBCs. </span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Padroni%20M%5BAuthor%5D&cauthor=true&cauthor_uid=32333166"><em>Padroni</em></a></strong><strong><em> et al. 2020 [24]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">70, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Gait difficulty and paresthesia. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EMG/NCS revealed demyelinating pattern</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 48 mg/dl. WBCs 1 cells/μL</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Scheidl et al. 2020 [25]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">54, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Paraparesis. Areflexia</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Admission EMG/NCS revealed demyelinating pattern</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.75pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 140 mg/dl. Normal WBCs</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Ottaviani et al. 2020 [26]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">66, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Difficulty walking, paraparesis. Areflexia then quadriparesis and facial weakness</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Day 10 EMG/NCS revealed mixed axonal and demyelinating patterns</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">GBS - mixed damage.</span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 108 mg/dl. Normal WBCs. Serum anti-glycolipid antibodies were absent</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Abdelnour%20L%5BAuthor%5D&cauthor=true&cauthor_uid=32354690"><em>Abdelnour</em></a></strong><strong><em> et al. 2020 [27]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">69, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Bilateral lower limb weakness. Areflexia</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Brain and spine MRIs were normal. EMG/NCS were not performed</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">GBS</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF was not performed</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Caamaño DS et al. 2020 [28]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">61, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Bilateral facial weakness. Unresponsive blink reflex on both eyes</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Brain MRI and CT were normal. EMG/NCS were not performed</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Atypical GBS variant - Facial diplegia</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF: protein 44 mg/dl. WBCs 0 cells</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Wei et al. 2020 [29]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">62, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Binocular diplopia and left ptosis. Left eye was down and out at rest. No anisocoria. No areflexia </span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Brain MRI and MRA were negative</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Left oculomotor nerve palsy</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF was not performed. CRP 142.21 mg/L</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em><span style="background: white;">Jin et al. 2020 [30]</span></em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">61, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Muscle tenderness & weakness of lower extremities</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EMG/NCS were not performed</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Rhabdomyolysis</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Myoglobin >12,000.0 μg/L. CK 11,842 U/L. LDH 2,347 U/L. CRP 111 mg/L</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Suwanwongse%20K%5BAuthor%5D&cauthor=true&cauthor_uid=32382463"><em>Suwanwongse</em></a></strong><strong><em> et al. 2020 [31]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">88, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Bilateral thighs weakness and pain</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EMG/NCS were not performed</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Rhabdomyolysis</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 35.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CK 13,581 U/L. LDH 364 U/L</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Vollono et al. 2020 [32]</em></strong><strong><em>^</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">78, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Myoclonic jerks of the right face and right limbs. Fever</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EEG: semi-rhythmic, irregular, high amplitude delta activity, predominantly over the left fronto-centro-temporal regions</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Focal status epilepticus</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 49pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CSF was not performed</span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Sohal et al. 2020 [33]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">72, M</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">AMS, episodes of tonic colonic movements</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CT head: no acute findings </span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EEG: S<span style="background: white;">ix left temporal seizures and left temporal sharp waves</span></span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Status epilepticus</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 44.5pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CSF was not performed</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Zanin et al. 2020 [34]</em></strong><strong><em>T</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">54, F</span></span></span></p>
</td>
<td style="width: 38.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td colspan="2" style="width: 33.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Neg</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">AMS</span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;"> </span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:normal;text-align:center;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">MRI: Periventricular confluent white matter hyperintensity</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">EEG: Two focal frontotemporal seizures</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Demyelinating lesions</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 41.8pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CSF: normal WBC, protein and glucose. No OCBs were sent</span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP 41.3 mg/L</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Paniz-Mondolfi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=32314810"><em>Paniz-Mondolfi</em></a></strong><strong><em> et al. 2020 [35]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">74, M</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Confusion and falls</span></span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT head: no acute findings</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Autopsy revealed 80 to 110 nm viral particles in frontal lobe brain (neurons & endothelial cells)</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Postmortem presence of virus in neural and capillary endothelial cells in frontal lobe from a patient infected with COVID-19</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 60.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP 183.5 mg/L. D-dimers 2925 ng/mL</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Gonz%C3%A1lez-Pinto%20T%5BAuthor%5D&cauthor=true&cauthor_uid=32352618"><em>González-Pinto</em></a></strong><strong><em> et al. 2020 [36] </em></strong><strong><em>¥</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">36, F</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Aphasia, right side hemiplegia. She was found down in her apartment</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT and CTA: Occlusion of left ICA, MCA, ACA</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Left ICA stroke</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP 156 mg/L. D-Dimer 7540 ng/ml.</span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;"> </span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Zhou et al. 2020 [37]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">75, F</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Left hemiplegia and right hemiparesis</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT: bilateral cerebral infarcts</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Right MCA and ACA stroke. Left ACA stroke. Bilateral legs DVTs</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 42.7pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP: 42.52 mg/L. </span></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">D-dimer >8000 ng/mL</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Valderrama et al. 2020 [38]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">52, M</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Right hemiparesis and aphasia. Left gaze, right partial hemianopia, facial weakness</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT: left MCA hyperdense sign</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CTA: left ICA occlusion</span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CTP: favorable mismatch ratio of 4.1</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Left ICA stroke </span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 44.95pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP 11 mg/L. D dimer > 10000 ng/ml. Fibrinogen 235 mg/dl</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Viguier et al 2020. [39]</em></strong><strong><em>X</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">66, M</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Right hemiparesis and aphasia. </span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT: left frontal hypoattenuation </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CTA: left CCA intraluminal floating thrombus</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">Multiple scattered infarcts within left carotid territory</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 40.9pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP </span> <span style="background: white;">219 mg/L. </span> <span style="background: white;"> D-dimer 2220 ng/ml. fibrinogen 820 mg/dl. </span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em>Hughes 2020. et al [40]</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">59, M</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Right fronto-temporal headache followed by right sided weakness and numbness</span></span></span></p>
</td>
<td style="width: 123.2pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CTV: Filling defect in the right sigmoid and transverse sinus</span></span></span></p>
</td>
<td style="width: 89.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CVT</span></span></span></span></p>
</td>
<td style="width: 84.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP: 20 mg/l. APTT: 19.7. Fibrinogen 490 mg/dl</span></span></span></span></p>
</td>
</tr>
<tr>
<td style="width: 72.15pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sharifi-Razavi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=32322398"><em>Sharifi-Razavi</em></a></strong><strong><em> et al. 2020 [41] </em></strong><strong><em>§</em></strong></span></span></span></p>
</td>
<td style="width: 42.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">79, M</span></span></span></p>
</td>
<td colspan="2" style="width: 39.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Pos</span></span></span></p>
</td>
<td style="width: 32.55pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">NA</span></span></span></p>
</td>
<td style="width: 1.65in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 52pt;vertical-align: top;">
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">Acute loss of consciousness</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;">CT: <span style="background: white;"> r</span>ight hemispheric massive intracerebral hemorrhage with intraventricular and subarachnoid hemorrhage</span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">ICH </span></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height: normal;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><span style="background: white;">CRP 10 mg/L. INR 1. PTT 64 seconds</span></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height:107%;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:normal;text-align:left;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><em> </em><strong><em>Table 1.</em></strong><em> Summary of the case reports of COVID-19 with neurological complications</em></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:.0001pt;line-height:normal;text-align:right;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><em> </em></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height: 107%;text-align:justify;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><strong><em><span style="line-height: 107%;">c</span></em></strong><em><span style="line-height: 107%;">, CSF analysis was limited due to traumatic LP; </span></em><strong><em><span style="line-height: 107%;">#</span></em></strong><em><span style="line-height: 107%;">, DWI: hyperintensity along the wall of the inferior horn of the right lateral ventricle; </span></em><em><span style="line-height: 107%;">*</span></em><em><span style="line-height: 107%;">, </span></em><em><span style="line-height: 107%; background: white;"> </span></em><em><span style="line-height: 107%;">SARS-CoV-2 infection was entirely confined to the central nervous system;</span></em><em><span style="line-height: 107%;">**</span></em><em><span style="line-height: 107%;">, <span style="background:white;">CSF anti-SARS-CoV-2 IgM& IgG were not detected; </span></span></em><strong><em><span style="line-height: 107%; background: white;">R</span></em></strong><em><span style="line-height: 107%; background: white;">,</span></em><em><span style="line-height: 107%;"> </span></em><em><span style="line-height: 107%; background: white;">CT head revealed left PCA distribution encephalomalacia. CSF was negative for </span></em><em><span style="line-height: 107%;"> </span></em><em><span style="line-height: 107%; background: white;">bacterial cultures, HSV PCR, RSV, and CMV PCR. ; </span></em><em><span style="line-height: 107%; background: white;">***</span></em><em><span style="line-height: 107%; background: white;">, Myelin oligodendrocyte glycoprotein antibody (MOG-IgG) and aquaporin 4 antibody results were requested, but no results reported;</span></em><strong><em><span style="line-height: 107%; background: white;">Q</span></em></strong><em><span style="line-height: 107%; background: white;">, Negative serum Anti-gangliosides;</span></em><strong><em><span style="line-height: 107%;">^</span></em></strong><em><span style="line-height: 107%; background: white;">, The patient has h</span></em><em><span style="line-height: 107%;">istory of </span></em><em><span style="line-height: 107%;">well</span></em><em><span style="line-height: 107%;">-controlled post-encephalitic epilepsy;<strong> </strong></span></em><strong><span style="line-height: 107%;">T</span></strong><span style="line-height: 107%;">,</span><em><span style="line-height: 107%;"> </span></em><span style="line-height: 107%;">MRI also reveals bulbo-medullary and C2-T6 focal intramedullary hyperintensities. No contrast enhancement; </span><strong><em><span style="line-height: 107%;">¥</span></em></strong><em><span style="line-height: 107%;">, The patient had free medical history but smoker. CTA revealed free-floating thrombus in the ascending aorta with no signs of aortic atheromatosis; </span></em><strong><em><span style="line-height: 107%;">§</span></em></strong><em><span style="line-height: 107%;">, The patient did not have history of hypertension or anticoagulation therapy. Platelets of 210 × 10<sup>9</sup>/L; </span></em><strong><em><span style="line-height: 107%;">X</span></em></strong><em><span style="line-height: 107%;">, Antiphospholipid antibodies were negative</span></em></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height:107%;text-align:justify;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><em>AMS: altered mental status. OP: opening pressure. GBS: Guillain barre syndrome. ACA: anterior cerebral artery. AMSAN: Acute motor-sensory axonal neuropathy. CCA: common carotid artery. CK: Creatine Kinase. CMAP: compound muscle action potential. CMV: Cytomegalovirus. COVID-19: Coronavirus disease 2019. CT: Computed tomography. CTA: CT angiography. CTP: CT perfusion. CTV: CT venogram. DVT: deep vein thrombosis. DWI: Diffusion Weighted Images. EEG: Electroencephalography. EMG: Electromyography. HSV: Herpes Simplex Virus. ICA: Internal carotid artery. ICU: Intensive care unit. INR: International normalized ratio. LDH: Lactate dehydrogenase. MCA: middle cerebral artery. MRI: Magnetic Resonance Imaging. NA: not applicable. NCS: nerve conduction studies. Neg: negative. Pos: positive. OCBs: oligoclonal bands. PMN: Polymorphonuclear cells. RT-PCT: Real-Time Polymerase Chain Reaction. SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. SNAP: sensory nerve action potential. T2WI/FLAIR: T-2 weighted Images/Fluid Attenuation Inversion Recovery</em><em>. VZV: Varicella Zoster Virus. CRP: C-reactive protein. PTT: partial thromboplastin time. WBCs: white blood cells. CSF: cerebral spinal fluid. </em><em>ICH: intracerebral hemorrhage. CVT: cerebral vein thrombosis. </em></span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height:107%;text-align:justify;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"><em> </em></span></span></span></p>
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<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height:107%;'><span style="color: rgb(0, 0, 0);"><span style="font-size: 12px;"><span style="font-family: Helvetica;"> </span></span></span></p>
<p style='margin-right:0in;margin-left:0in;font-size:15px;font-family:"Calibri",sans-serif;margin-top:0in;margin-bottom:8.0pt;line-height:107%;'><span style="font-family: Helvetica; font-size: 12px; color: rgb(0, 0, 0);"> </span></p>
5% (n=2) of the CVIs were cerebral vein thrombosis (CVT), 5% (n=2) were intracerebral hemorrhage (ICH), 2.5% (n=1) were aneurysmal subarachnoid hemorrhage & ICH, and 87.5% (n=35) were ischemic stroke. 3 out of the 35 patients were cardioembolic stroke, 5 were small vessel disease stroke, and 27 were large vessel occlusion (LVO) stroke. 25.7% (n=9) of the ischemic stroke patients had significant elevation of D-dimer level (>7000 ng/ml), 28.6 % (n=10) had significant elevation of C-reactive protein (>100mg/L), 22.8% (n=8) had elevated fibrinogen (> 500 mg/dl), and 14.3% (n=5) were tested positive for lupus anticoagulant antibodies. Out of the 27 LVO stroke patients, 7 were under the age of 50, 6 underwent thrombectomy, 4 were given IV tPA, 6 were given therapeutic low molecular weight heparin (LMWH), 3 were given apixaban, 4 were given dual antiplatelets (DAPs), and one was given rivaroxaban and DAPs, and 6 died. One of the ischemic stroke patients developed hemorrhagic conversion after thrombectomy. The LVO stroke were distributed in the following territories: left middle cerebral artery territory (MCA) (n=6), right MCA (n=6), left internal carotid artery (ICA) (n=2), right ICA (n=2), left common carotid artery (n=1), basilar artery (n=1), left vertebral artery (n=1), left posterior cerebral artery (PCA) (n=1), right PCA (n=1), bilateral multiple vascular territory infarcts (n=2), and unspecified (n=4). Stroke with LVO was the presenting manifestation of COVID-19 infection in 8 patients, 3 of which were under the age of 45 [Figure 3].
17.4% (n=4) of the NMDs patients had rhabdomyolysis, 4.3 % (n=1) had polyneuritis cranialis, 4.3% (n=1) had oculomotor nerve palsy, and 73.9% (n=17) had Guillain Barre syndrome (GBS). 7 out of the 17 GBS cases had facial weakness. One of which had solely facial diplegia as a neurologic syndrome. In 2 cases, GBS was the first presentation of SARS-CoV-2 infection. While in 14 other patients, GBS developed 3-24 days after the onset of flu-like symptoms. One patient presented 2 weeks after anosmia and ageusia without respiratory or GI symptoms. Electrophysiologic studies showed evidence of acute motor and sensory axonal variant (AMSAN) in 5 patients, mixed axonal and demyelinating pattern in 2 patients, and demyelinating patterns in 6 patients. EMG was not performed in 4 patients, one of which was diagnosed with Miller Fisher syndrome with positive serum GD1b-IgG antibody. CSF studies revealed albuminocytologic dissociation in 10 patients, were normal in 3 patients (protein <45 mg/dl, WBCs 0-5 cells/μ). In one patient CSF protein and WBCs were 54 mg/dl and 9 cells/μL respectively. 14 out of 17 patients received IVIG, one patient received IVIG and plasmapheresis, 1 patient showed spontaneous recovery and one patient received prednisone. 6 out of the 17 patients developed respiratory failure, one of which died (Table 2).
Author, Year
|
Mean age (y)
|
Patients, Number
|
Male/Female, Number
|
SARS-CoV-2
|
Neurological Presentation
|
Neurological investigations
|
Neurological
Diagnosis
|
Nasal
Swab
|
CSF
|
Toscano et al. 2020 [42] *
|
58.4
|
5
|
4/1
|
Pos (4)
Neg (1)
|
Neg (5)
|
Tetraparesis (2), paraplegia (1), paresthesia (2), facial weakness (4), ataxia (2). Areflexia (5)
|
Days 3-12 EMG/NCS: axonal (3), demyelination (2). MRI: caudal nerves enhancement (2), facial nerves enhancement (1), normal (2)
|
GBS: AMSAN variant (3), AIDP variant (2)
|
Gutiérrez-Ortiz et al. 2020 [43] **
|
44.5
|
2
|
2/0
|
Pos (2)
|
Neg (2)
|
1.Vertical diplopia, perioral paresthesia, gait instability. Areflexia
|
Pos GD1b-IgG antibody
CSF: protein 80 mg/dl, WBCs 0 cells. No EMG was performed
|
Miller Fisher syndrome (right INO and right fascicular oculomotor palsy)
|
2. Diplopia. Areflexia
|
CSF: protein 62 mg/dl, WBCs 2 cells /μL
|
Polyneuritis cranialis (bilateral abducent nerve palsy)
|
Chan et al. 2020 [44]
|
73
|
2
|
1/1
|
Pos (2)
|
NA
|
Generalized weakness (2), leg twitching (1)
|
Serum (ave): CK 2313 U/L: LDH 517.5 U/L. CRP: 11.25 mg/dl
|
Rhabdomyolysis
|
Bernard-Valnet et al. 2020 [45] ∞
|
65.5
|
2
|
0/2
|
Pos (2)
|
Neg (2)
|
1. tonic-clonic seizure. Verbal and motor perseverations
|
EEG: status epilepticus
MRI brain: normal
CSF: protein 46.6 mg/dl, WBCs 17 cells /mm3 (97% lymphs)
|
Meningoencephalitis
|
2. Intense headache and AMS. Left hemianopia and sensory hemineglect
|
MRI brain: normal
CSF: 46.1 mg/dl, WBCs 21 cells /mm3 (89% lymphs)
|
Meningoencephalitis
|
Dogan et al. 2020 [46]W
|
49.1
|
6
|
5/1
|
Pos (6)
|
Neg (6)
|
Failure to recover consciousness or severe agitation during weaning from mechanical ventilation (6)
|
MRI: Cortical or WM hyperintensities, contrast enhancement, and sulcal hemorrhages (3)
|
Autoimmune Meningoencephalitis
|
Avula et al 2020. [47]q
|
81
|
4
|
1/3
|
Pos (4)
|
NA
|
1. AMS
|
CT head and CTA. CRP 260 mg/L
|
Left MCA stroke
|
2. Dysarthria, left facial droop, left hemiparesis and hemineglect
|
CT head and CTA
|
Right MCA stroke
|
3. AMS, left hemiparesis
|
CT head, CTA, CTP.
CRP 162.4 mg/L. D-dimer 13966 ng/ml
|
Right ICA stroke
|
4. Fifteen minutes of right arm weakness, numbness, aphasia
|
MRI (positive for stroke) and MRA. D-dimer 3,442ng/ml
|
TIA/Left MCA stroke
|
Al Saiegh et al. 2020. [48]V
|
46.5
|
2
|
1/1
|
Pos (2)
|
Neg (2)
|
1. Sudden headache, loss of consciousness
|
CT head, conventional angiography and CSF testing
|
Posterior fossa aneurysmal SAH and ICH
|
2. Right hemiparesis, aphasia
|
CT head, CTA and CSF testing
|
Left MCA stroke
|
Beyrouti et al. 2020. [49] €
|
69.33
|
6
|
5/1
|
Pos (6)
|
NA
|
1. Left arm incoordination, 7 days later, bilateral incoordination and right homonymous hemianopia
|
MRI brain. Pos lupus anticoagulant, D-dimer > 80,000 ng/mL. CRP 305.4 mg/L. Fibrinogen 950 mg/dl
|
Left vertebral artery occlusion-> left PICA stroke-> 7 days later left PCA stroke
|
2. Confusion, incoordination
|
CT head,.Pos lupus anticoagulant. D-dimer 7,750 ng/mL. CRP 150.1 mg/L. Fibrinogen 703 mg/dl
|
Left cerebellar and right parietooccipital infarcts
|
3. Dysarthria, right hemiparesis
|
CT head,.Neg lupus anticoagulant, D-dimer 16,100 ng/mL. CRP 161.2mg/L. Fibrinogen 530 mg/dl
|
Left PCA stroke
|
4. Dysarthria, left hemiparesis
|
MRI brain. Pos lupus anticoagulant, D-dimer 27,190 ng/mL. CRP 12.8 mg/L. Fibrinogen 463 mg/dl
|
Right MCA stroke
|
5. Dysarthria, left hemiparesis
|
CT head and CTA. Pos lupus anticoagulant, D-dimer 19,450 ng/mL. CRP 27.7 mg/L. Fibrinogen 496 mg/dl
|
Right MCA stroke
|
6. Dysphasia, right hemiparesis
|
MRI. Pos lupus anticoagulant, D dimer 1,080 ng/mL. CRP 179.9 mg/L
|
Basilar artery thrombus and bilateral P2 stenosis
|
Oxley et al. 2020. [50] ∆
|
40.4
|
5
|
4/1
|
Pos (5)
|
NA
|
1. Left hemiplegia, homonymous hemianopia, right gaze preference
|
CT, CTA, CTP, MRI. D-dimer 460 ng/ml, Fibrinogen 501 mg/dl
|
Right ICA stroke
|
2. AMS, dysphasia, right hemiplegia
|
CT, CTA, MRI. D-dimer 52 ng/ml, Fibrinogen 370 mg/dl.
|
Left MCA stroke
|
3. AMS, left hemiplegia, homonymous hemianopia, right gaze preference, ataxia
|
CT, CTA, CTP, MRI. D-dimer 2230 ng/ml, Fibrinogen 739 mg/dl
|
Right PCA stroke
|
4. AMS, global aphasia, right hemiplegia, left gaze
|
CT, CTA, MRI. D-dimer 1388 ng/ml, Fibrinogen 443 mg/dl
|
Left MCA stroke
|
5. AMS, left hemiplegia, dysarthria, left facial droop
|
CT, CTA, CTP. D-dimer 1750 ng/ml, Fibrinogen 531 mg/dl.
|
Right MCA stroke
|
Tunç et al 2020. [51]
|
65.25
|
4
|
2/2
|
Pos (4)
|
NA
|
1. Left hemiparesis, dysarthria, left facial droop
|
MRI brain. D-dimer 803 ng/mL. CRP 142 mg/L
|
Right MCA stroke
|
2. Right hemiparesis, dysarthria
|
MRI brain. D-dimer 1040 ng/mL CRP 4 mg/L
|
Left lenticulostriate artery infarction
|
3. Right hemiparesis, loss of consciousness
|
MRI brain. D-dimer 644 ng/mL. CRP 33 mg/L
|
Left MCA stroke
|
4. Left hemi-hypoesthesia, mild ataxia
|
MRI brain. D-dimer 378 ng/mL. CRP 366 mg/L
|
Right pontine infarction
|
Li et al. 2020. [52] ⱡ
|
71.61
|
13
|
7/6
|
Pos (13)
|
NA
|
No neurological presentations were reported
|
CTV (1), CT head (1 R MCA and 1 L BG hg). CRP (median) 51.1 mg/L (13). D-dimer (median) 6900 ng/ml (13)
|
ICH (1). CVT (1). LVO (5). SVD stroke (3). CE stroke (3)
|
Table 2. Summary of the case series of COVID-19 with neurological complications
*,CSF: protein (mg/dl): 101, 123, 193, normal protein, 40. WBCs (cells per mm3): 4,0,0,0,3. Antiganglioside antibodies: negative (3), not tested (2); **, Case#1: Exam revealed limited adduction and downgaze movements of his right eye, and left eye nystagmus on left gaze. Case#2: Exam revealed limited abduction in both eyes, and fixation nystagmus, with the upper gaze more impaired; ∞, Case#1 Negative CSF anti-NMDA antibodies. Case #1&2: Negative HSV/VZV PCRs; W, serum ferritin levels remarkably improved post plasmapheresis in recovering patients. CSF (median): protein 69.4 mg/dl. WBCs 0 cells/μL. Glucose 116. OCBs neg (5); q, Case # 4: MRI/MRA revealed left medial temporal lobe small infarct and left M1 stenosis; V, After 10 days, patient#2 presented with hemorrhagic conversion and hydrocephalus; €, patient 1 and 4 had PEs. Patient 2 INR was 3.6 (patient was already on warfarin). Patient 6 had right thalamus, left pons, right occipital lobe and right cerebellar infarcts. 1 patient had non-treated atrial fibrillation, 1 had treated atrial fibrillation, 1 had previous stroke; ∆, 2 patients had diabetes, 1 patient had hyperlipidemia and hypertension; ⱡ, 9 out 13 patients had hypertension, 6 out of 13 had diabetes mellitus, 3 out of 13 had cardiovascular disease, 1 out of 13 had malignancy, and 11 out of 13 had severe COVID-19 with multiorgan failure.
AMS: altered mental status. GBS: Guillain barre syndrome. ACA: anterior cerebral artery. AMSAN: Acute motor-sensory axonal neuropathy. CK: Creatine Kinase. CMAP: compound muscle action potential. COVID-19: Coronavirus disease 2019. CT: Computed tomography. CTA: CT angiography. CTP: CT perfusion. CTV: CT venogram. DVT: deep vein thrombosis. DWI: Diffusion Weighted Images. EEG: Electroencephalography. EMG: Electromyography. ICA: Internal carotid artery. ICU: Intensive care unit. INR: International normalized ratio. LDH: Lactate dehydrogenase. MCA: middle cerebral artery. MRI: Magnetic Resonance Imaging. NA: not applicable. NCS: nerve conduction studies. Neg: negative. Pos: positive. OCBs: oligoclonal bands. PMN: Polymorphonuclear cells. Lymphs: lymphocytes. RT-PCT: Real-Time Polymerase Chain Reaction. SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. SNAP: sensory nerve action potential. CRP: C-reactive protein. PTT: partial thromboplastin time. WBCs: white blood cells. CSF: cerebral spinal fluid. SAH: subarachnoid hemorrhage. ICH: intracerebral hemorrhage. L: left. R: right. PICA: posterior inferior cerebellar artery. PEs: pulmonary embolisms. LVO: large vessel occlusion. SVD: small vessel disease. CE: cardioembolic. CVT: cerebral vein thrombosis. WM: white matter. AIDP: acute inflammatory demyelinating polyradiculoneuropathy.
|
80% (n=12) of the CNS infection related complications were meningoencephalitis, 6.6 % (n=1) had rhombencephalitis, 6.6% (n=1) had acute necrotizing hemorrhagic encephalopathy, and 6.6 % (n=1) had encephalopathy. In the 12 meningoencephalitis cases, only 4 CSFs revealed lymphocytic pleocytosis, two of which had positive CSF SARS-CoV-2 RT-PCR. 9 patients developed respiratory failure, 6 of which received plasmapheresis and one died. Furthermore, one of the status epilepticus patients was focal status epilepticus. Finally, The CSF of the patient with CNS demyelinating lesions was normal and oligoclonal bands were not sent (Table 3).
Author, Year
|
Patients, Number
|
Onset of neurologic syndrome, Days `
|
Respiratory Failure (0=no, 1=yes)
|
Treatment
|
Outcome (0=no, 1=yes)
|
Good
|
Recovering
|
Poor
|
Deceased
|
Poyiadji et al. 2020 [10]
|
1
|
3
|
NA
|
IVIG
|
NA
|
NA
|
NA
|
NA
|
Moriguchi et al. 2020 [11]
|
1
|
9
|
1
|
Antimicrobials, steroid
|
0
|
0
|
1
|
0
|
Duong et al & Haung et al. 2020 [12&13]
|
1
|
0
|
0
|
AEDs, transient antimicrobials
|
0
|
1
|
0
|
0
|
Ye et al. 2020 [14]
|
1
|
13
|
1
|
Antimicrobials
|
1
|
0
|
0
|
0
|
Yin et al. 2020 [15]
|
1
|
13
|
0
|
Antimicrobials
|
1
|
0
|
0
|
0
|
Filatov et al. 2020 [16]
|
1
|
1
|
1
|
AEDs, antimicrobials
|
0
|
0
|
1
|
0
|
Wong et al. 2020 [17]
|
1
|
12
|
0
|
Antimicrobials, gabapentin
|
1
|
0
|
0
|
0
|
Zhao et al. 2020 [18] *
|
1
|
-8
|
0
|
IVIG
|
1
|
0
|
0
|
0
|
Sedaghat et al. 2020 [19]
|
1
|
14
|
0
|
IVIG
|
NA
|
NA
|
NA
|
NA
|
Virani et al. 2020 [20]
|
1
|
10
|
1
|
IVIG
|
0
|
1
|
0
|
0
|
El-Otmani et al. 2020 [21]
|
1
|
3
|
0
|
IVIG
|
0
|
0
|
1
|
0
|
Alberti et al. 2020 [22]
|
1
|
7
|
1
|
IVIG
|
0
|
0
|
0
|
1
|
Camdessanche et al. 2020 [23]
|
1
|
11
|
1
|
IVIG
|
NA
|
NA
|
NA
|
NA
|
Padroni et al. 2020 [24]
|
1
|
24
|
1
|
IVIG
|
0
|
0
|
1
|
0
|
Scheidl et al. 2020 [25] **
|
1
|
14
|
0
|
IVIG
|
1
|
0
|
0
|
0
|
Ottaviani et al. 2020 [26]
|
1
|
10
|
1
|
IVIG
|
0
|
0
|
1
|
0
|
Abdelnour et al. 2020 [27] *
|
1
|
-7
|
0
|
NA
|
1
|
0
|
0
|
0
|
Caamaño DS et al. 2020 [28]
|
1
|
7
|
0
|
Steroid
|
0
|
1
|
0
|
0
|
Wei et al. 2020 [29] *
|
1
|
-7
|
1
|
IVIG, steroid, antimicrobials
|
0
|
0
|
0
|
1
|
Jin et al. 2020 [30]
|
1
|
15
|
1
|
IVF
|
0
|
1
|
0
|
0
|
Suwanwongse et al. 2020 [31]
|
1
|
0
|
0
|
IVF
|
0
|
1
|
0
|
0
|
Vollono et al. 2020 [32]
|
1
|
0
|
0
|
AEDs
|
1
|
0
|
0
|
0
|
Sohal et al. 2020 [33]
|
1
|
3
|
1
|
AEDs
|
0
|
0
|
0
|
1
|
Zanin et al. 2020 [34] **
|
1
|
NA
|
1
|
AEDs
|
0
|
1
|
0
|
0
|
Paniz-Mondolfi et al. 2020 [35] ***
|
1
|
0
|
1
|
NA
|
0
|
0
|
0
|
1
|
González-Pinto et al. 2020 [36]
|
1
|
NA
|
1
|
NA
|
0
|
0
|
0
|
1
|
Zhou et al. 2020 [37]
|
1
|
24
|
1
|
DAPs + rivaroxaban
|
0
|
1
|
0
|
0
|
Valderrama et al. 2020 [38]
|
1
|
7
|
0
|
IV tPA + Thrombectomy
|
0
|
1
|
0
|
0
|
Viguier et al 2020. [39]
|
1
|
7
|
0
|
LMWH
|
0
|
1
|
0
|
0
|
Hughes et al. 2020 [40]
|
1
|
0
|
0
|
LMWH
|
0
|
1
|
0
|
0
|
Sharifi-Razavi et al. 2020 [41]
|
1
|
3
|
1
|
NA
|
NA
|
NA
|
NA
|
NA
|
Toscano et al. 2020 [42]
|
5
|
7 (2), 10 (2), 5 (1)
|
1(3)
|
IVIG (5), Plex (1)
|
1(1)
|
1(2)
|
1(2)
|
0
|
Gutiérrez-Ortiz et al. 2020 [43] q
|
2
|
5 (1), 3 (1)
|
0
|
IVIG (1)
|
1(2)
|
0
|
0
|
0
|
Chan et al. 2020 [44]
|
2
|
0 (2)
|
1(2)
|
IVF
|
0
|
1(1)
|
1(1)
|
0
|
Bernard-Valnet et al. 2020 [45]
|
2
|
5 (1), 17 (1)
|
NA
|
AEDs & transient antimicrobials (2)
|
1(2)
|
0
|
0
|
0
|
Dogan et al. 2020 [46]V
|
6
|
NA
|
1(6)
|
Plex (6)
|
0
|
1(4)
|
1(1)
|
1(1)
|
Avula et al 2020. [47] q
|
4
|
2 (1), 0 (3)
|
1 (3)
|
Aspirin + statin (1), no acute treatment (4)
|
0
|
1(1)
|
0
|
1(3)
|
Al Saiegh et al. 2020. [48]
|
2
|
7 (1), 0 (1)
|
1(2)
|
FD stent + EVD (1), thrombectomy (1)
|
0
|
1(2)
|
0
|
0
|
Beyrouti et al. 2020. [49] *
|
6
|
-2 (1), 8 (1), 10 (1), 15 (2), 24 (1)
|
1(3)
|
DAPs (1), apixaban (1), LMWH (3), IV tPA (2)
|
0
|
0
|
1(5)
|
1(1)
|
Oxley et al. 2020. [50]
|
5
|
0(3), 7(1)
|
NA
|
Aspirin (2), Apixaban (2), stent (1), DAPs (1), IV tPA (1), thrombectomy (4), hemicraniectomy (1)
|
1(1)
|
1(3)
|
1(1)
|
0
|
Tunç et al 2020. [51]
|
4
|
4 (1), 1 (1), 7 (1), 2 (1)
|
0
|
DAPs (2), aspirin + low dose LMWH (2)
|
1(2)
|
2(2)
|
0
|
0
|
Li et al. 2020. [52]
|
13
|
12 (median)
|
NA
|
LMHW (2 LVO, 2 CE, 1 CVT). AP (3 SVD, 3 LVO, 1 CE)
|
0
|
1 (2)
|
1 (6)
|
1(5; one of them LVO)
|
Table 3. Chronological summery of patients’ hospital course
`, defined by onset after respiratory or gastrointestinal symptoms or anosmia or dysgeusia, if the onset of neurological presentation (zero) means it was the initial presentation of SARS-CoV-2 infection; *, 8,7,7,2 days respectively after the neurological presentation, the patients developed respiratory symptoms; **, The patients neurological presentation proceeded by anosmia and dysgeusia, there were no respiratory symptoms; ***, 5 days after neurological presentation, CXR showed BL lungs densities; q, two patients had neurological presentation 3,2 days respectively after gastroenterological symptoms, there were no respiratory symptoms; V, Patients regained consciousness after the 3rd cycle (1), 2nd cycle (1), and 1st cycle (2) of plasmapheresis.
AEDs: antiepileptic drugs. DAPs: dual antiplatelet therapy. AP: antiplatelet. EVD: external ventricular drain. IVF: intravenous fluid. IVIG: intravenous immunoglobulin. LMWH: low molecular weight heparin. NA: not applicable. Plex: plasmapheresis. RS: respiratory symptoms like cough and or shortness of breath. LVO: large vessel occlusion. SVD: small vessel disease. CE: cardioembolic. CVT: cerebral vein thrombosis.
|