Aldridge DR, Tranah EJ, Shawcross DL (2015) Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation. J Clin Exp Hepatol 5:S7-S20
Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier health sciences
Bosoi CR, Rose CF (2009) Identifying the direct effects of ammonia on the brain. Metab Brain Dis 24(1):95-102
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1-2):248-254
Brown J, Wang H, Hajishengallis GN, Martin M (2011) TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 90(4):417-427
Cristóvão AC, Campos FL, Je G, Esteves M, Guhathakurta S, Yang L, Beal MF, Fonseca BM, Salgado AJ, Queiroz J (2020) Characterization of a Parkinson’s disease rat model using an upgraded paraquat exposure paradigm. Eur J Neurosci 52(4):3242-3255
Damink SWMO, Jalan R, Redhead DN, Hayes PC, Deutz NEP, Soeters PB (2002) Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS. Hepatology 36(5):1163-1171
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67(5):446-457
El-Marasy SA, El Awdan SA, Abd-Elsalam RM (2019) Protective role of chrysin on thioacetamide-induced hepatic encephalopathy in rats. Chem Biol Interact 299:111-119
Fakurazi S, Sharifudin SA, Arulselvan P (2012) Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature. Molecules 17(7):8334-8350
Fathy SM, Mahmoud MS (2021) Moringa oleifera Lam. leaf extract mitigates carbon tetrachloride-mediated hepatic inflammation and apoptosis via targeting oxidative stress and toll-like receptor 4/ nuclear factor kappa B pathway in mice. Food Sci. Hum. wellness 10(3):383-391
Fathy S, Said N (2019) Immunomodulation and antigenotoxic effects of propolis in paclitaxel-treated rats. Egypt J Zool 72(72):45-56
Furtado M, Katzman MA (2015) Examining the role of neuroinflammation in major depression. Psychiatry Res 229(1-2):27-36
Gutiérrez-de-Juan V, López de Davalillo S, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Fernández-Tussy P, Simon J, Lopitz-Otsoa F, de Las Heras J, Iruzubieta P (2017) A morphological method for ammonia detection in liver. PLoS One 12(3):e0173914
Hafkenscheid JC, Dijt CC (1979) Determination of serum aminotransferases: activation by pyridoxal-5’-phosphate in relation to substrate concentration. Clin Chem 25(1):55-59
Han C, Sun T, Xv G, Wang S, Gu J, Liu C (2019) Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways. Mol Med Rep 20(4):3095-3102
Heidari R, Jamshidzadeh A, Niknahad H, Mardani E, Ommati MM, Azarpira N, Khodaei F, Zarei A, Ayarzadeh M, Mousavi S (2016) Effect of taurine on chronic and acute liver injury: Focus on blood and brain ammonia. Toxicol reports 3:870-879
Idoga ES, Ambali SF, Ayo JO, Mohammed A (2018) Assessment of antioxidant and neuroprotective activities of methanol extract of Moringa oleifera Lam. leaves in subchronic chlorpyrifos-intoxicated rats. Comp Clin Path 27(4):917-925
Jollow DJ, Mitchell JR, Zampaglione N al, Gillette JR (1974) Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11(3):151-169
Khan A, Shal B, Naveed M, Shah FA, Atiq A, Khan NU, Kim YS, Khan S (2019) Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury. Neurotoxicology 72:38-50
Kong Y, Le Y (2011) Toll-like receptors in inflammation of the central nervous system. Int Immunopharmacol 11(10):1407-1414
Kou X, Li B, Olayanju JB, Drake JM, Chen N (2018) Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients 10(3):343
Kubera M, Obuchowicz E, Goehler L, Brzeszcz J, Maes M (2011) In animal models, psychosocial stress-induced (neuro) inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog Neuro-Psychopharmacology Biol Psychiatry 35(3):744-759
Kurek A, Kucharczyk M, Detka J, Ślusarczyk J, Trojan E, Głombik K, Bojarski B, Ludwikowska A, Lasoń W, Budziszewska B (2016) Pro-apoptotic action of corticosterone in hippocampal organotypic cultures. Neurotox Res 30(2):225-238
Liu Y, Wen P, Zhang X, Dai Y, He Q (2018) Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. Int J Mol Med 42(2):755-768
Lıu Z, Tıan J (2016) Changes of MDA and SOD in brain tissue after secondary brain injury with seawater immersion in rats. Turk Neurosurg 26(3):384-388
Lu L, Wu C, Lu B, Xie D, Wang Z, Azami NLB, An Y, Wang H, Ye G, Sun M (2020) BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats. J Ethnopharmacol 249:112301
Mahdi HJ, Khan NAK, Asmawi MZ Bin, Mahmud R, Vikneswaran A, Murugaiyah L (2018) In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund’s adjuvant (CFA)-induced arthritis in rats. Integr Med Res 7(1):85-94
Makni M, Chtourou Y, Barkallah M, Fetoui H (2012) Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats. Toxicol Ind Health 28(7):655-662
Mao S-S, Hua R, Zhao X-P, Qin X, Sun Z-Q, Zhang Y, Wu Y-Q, Jia M-X, Cao J-L, Zhang Y-M (2012) Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway. J Neurotrauma 29(10):1941-1959
Mello BSF, Monte AS, McIntyre RS, Soczynska JK, Custódio CS, Cordeiro RC, Chaves JH, Vasconcelos SMM, Júnior HVN, de Sousa FCF (2013) Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. J Psychiatr Res 47(10):1521-1529
Millan MJ (2004) The role of monoamines in the actions of established and “novel” antidepressant agents: a critical review. Eur J Pharmacol 500(1-3):371-384
Nunes-Souza V, Alenina N, Qadri F, Penninger JM, Santos RAS, Bader M, Rabelo LA (2016) CD36/sirtuin 1 axis impairment contributes to hepatic steatosis in ACE2-deficient mice. Oxid. Med. Cell. Longev. 2016:
Ogaly HA, Eltablawy NA, Abd-Elsalam RM (2018) Antifibrogenic influence of Mentha piperita L. essential oil against CCl4-induced liver fibrosis in rats. Oxid. Med. Cell. Longev. 2018:
Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351-358
Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229(2):327
Risal P, Hwang PH, Yun BS, Yi H-K, Cho BH, Jang KY, Jeong YJ (2012) Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice. J Nat Prod 75(10):1683-1689
Sampson EJ, Whitner VS, Burtis CA, McKneally SS, Fast DM, Bayse DD (1980) An interlaboratory evaluation of the IFCC method for aspartate aminotransferase with use of purified enzyme materials. Clin Chem 26(8):1156-1164
Shaalan S, Radwan OK, Saleh H (2017) Role of Wheat Germ Oil against Carbon Tetrachloride Induced Neurotoxicity in Brain Tissues of Adult Male Mice. Egypt J Zool 174(5542):1-18
Shal B, Khan A, Naveed M, Ali H, Seo EK, Choi H, Khan S (2020) Neuroprotective effect of 25-Methoxyhispidol A against CCl4-induced behavioral alterations by targeting VEGF/BDNF and caspase-3 in mice. Life Sci 117684
Shim J-Y, Kim M-H, Kim H-D, Ahn J-Y, Yun Y-S, Song J-Y (2010) Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol 242(3):318-325
Singh D, Arya PV, Aggarwal VP, Gupta RS (2014) Evaluation of antioxidant and hepatoprotective activities of Moringa oleifera Lam. leaves in carbon tetrachloride-intoxicated rats. Antioxidants 3(3):569-591
de Souza Machado F, Marinho JP, Abujamra AL, Dani C, Quincozes-Santos A, Funchal C (2015) Carbon tetrachloride increases the pro-inflammatory cytokines levels in different brain areas of Wistar rats: the protective effect of acai frozen pulp. Neurochem Res 40(9):1976-1983
Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85(3):367-370
Tesfay SZ, Bertling I, Odindo AO, Workneh TS, Mathaba N (2011) Levels of anti-oxidants in different parts of moringa (Moringa oleifera) seedling. African J Agric Res 6(22):5123-5132
Vairappan B, Sundhar M, Srinivas BH (2019) Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl 4-Induced Cirrhotic Mice. Mol Neurobiol 56(7):4718-4729
Valentine JS, Hart PJ (2003) Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc Natl Acad Sci 100(7):3617-3622
Vogelzangs N, Beekman ATF, De Jonge P, Penninx B (2013) Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry 3(4):e249-e249
Yoshimura A, Shichita T (2012) Post-ischemic inflammation in the brain. Front Immunol 3:132
Yue S, Xue N, Li H, Huang B, Chen Z, Wang X (2020) Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro. Inflammation
Zhou Z, Hou J, Mo Y, Ren M, Yang G, Qu Z, Hu Y (2020) Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4/2 signaling pathway in APP/PS1 mice. Eur J Pharmacol 869:172857