Acknowledgements
We thank the patient for permission to report his case. We thank the CAPTURE trial team, including Hamid Ahmod, Natalie Ash, Ravinder Dhaliwal, Lauren Dowdie, Tara Foley, Lucy Holt, Justine Korteweg, Charlotte Lewis, Karla Lingard, Mary Mangwende, Aida Murra, Kema Peat, Sarah Sarker, Nahid Shaikh, and Fiona Williams. We thank Firza Gronthoud, Gail Gardner, Robyn Shea and their teams for support on sample collation. We acknowledge the tremendous support from the clinical and research teams at participating units at the Royal Marsden Hospital. We thank Mike Gavrielides for informatics support, and Brigitta Stockinger for valuable discussions. We also thank the Volunteer Staff at The Francis Crick Institute, and the Crick COVID19 consortium. Due to limitations on cited references and the pace at which the field is evolving, we acknowledge researchers in COVID-19 vaccines and immune responses in patients with cancer. The CAPTURE study is a substudy of TRACERx Renal, and is sponsored by The Royal Marsden NHS Foundation Trust and funded from a grant from the Royal Marsden Cancer Charity (RMCC) Programme (Ref. RMCC32). TRACERx Renal is partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the Royal Marsden Hospital and Institute of Cancer Research (ICR) (A109). This work was supported by the Francis Crick Institute receives its core funding from Cancer Research UK (CRUK) (FC010110), the UK Medical Research Council (FC010110), and the Wellcome Trust (FC010110). This research was funded in whole, or in part, by the Wellcome Trust (FC0010988). For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Author contributions
S.T., L.A., S.S., and A.F. contributed to study design. L.A., K.R., A.F., and S.T drafted the manuscript. S.S, A.F., and L.A. contributed to the collection and processing of clinical specimens. A.F., K.W., and M.C. performed laboratory analysis. A.F. and L.A contributed to visualisations. S.S., L.A., N.J-H., D.L., I.C., N.S., and C.F. provided clinical data. All authors critically reviewed the manuscript for intellectual content, approved the final version of the manuscript for submission, and agreed to be accountable for all aspects of the work.
Competing interests declaration
L.A. is funded by the Royal Marsden Cancer Charity. A.F. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 892360. M.C., K.A.W. and R.J.W. receives core funding from the Francis Crick Institute (FC001218). J.S. and W.H. are employees and shareholders at Serimmune Inc. N.J-H receives funding from Cancer Research UK (grant reference number C65320/A26413). J.L. has worked in a consulting or advisory role for Achilles Therapeutics, AstraZeneca, Boston Biomedical, Bristol Myers Squibb, Eisai, EUSA Pharma, GlaxoSmithKline, Imugene, Incyte, iOnctura, Ipsen, Kymab, Merck Serono, Merck Sharp & Dohme, Nektar Therapeutics, Novartis, Pierre Fabre, Pfizer, Roche/Genetech, Secarna, and Vitaccess; and has received support from NIHR RM/ICR Biomedical Research Centre for Cancer, and institutional research support from Achilles Therapeutics, Aveo, Bristol Myers Squibb, Covance, Immunocore, Merck Sharp & Dohme, Nektar Therapeutics, Novartis, Pharmacyclics, Pfizer, and Roche. D.L. is the recipient of the Australasian Gastro-Intestinal Trials Group/Merck Clinical Research Fellowship. I.C. has worked in a consulting or advisory role for Eli-Lilly, Bristol Meyers Squibb, MSD, Bayer, Roche, Merck-Serono, Five Prime Therapeutics, Astra-Zeneca, OncXerna, Pierre Fabre, Boehringer Ingelheim, Incyte, and Astella; and has received research funding from Eli-Lilly and Janssen-Cilag; and has received honorarium from Eli-Lilly and Eisai. S.T. has received speaking fees from Roche, Astra Zeneca, Novartis and Ipsen. G.K. receives core funding from the Francis Crick Institute (FC0010099). S.T. is funded by Cancer Research UK (grant reference number C50947/A18176), the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC0010988), the UK Medical Research Council (FC0010988), and the Wellcome Trust (FC0010988), the National Institute for Health Research (NIHR) Biomedical Research Centre at the Royal Marsden Hospital and Institute of Cancer Research (grant reference number A109), the Royal Marsden Cancer Charity, The Rosetrees Trust (grant reference number A2204), Ventana Medical Systems Inc (grant reference numbers 10467 and 10530), the National Institute of Health (Bethesda) and Melanoma Research Alliance. All other authors declare no conflicts of interest.
Data availability
All requests for raw and analysed data, materials, and CAPTURE study protocol will be reviewed by the CAPTURE Trials Team, Skin and Renal Clinical Trials Unit, The Royal Marsden NHS Foundation Trust ([email protected]) to determine if the request is subject to confidentiality and data protection obligations. Data and materials that can be shared will be released via a material transfer agreement.
The CAPTURE consortium
The members of the CAPTURE consortium include Lewis Au, Susana Banerjee, Katie Bentley, Shree Bhide, Laura Amanda Boos, Fiona Byrne, The Crick COVID-19 Consortium, Ian Chau, David Cunningham, Joanne Droney, Annika Fendler, Andrew Furness, Camille Gerard, Firza Gronthud, Kevin Harrington, Adrian Hayday, Shaman Jhanji, Robin Jones, George Kassiotis, Yasir Khan, Sacheen Kumar, James Larkin, Steve K.W. Leung, Michael Jones, Paula Lorgelly, Richard Martin, Ethna McFerran, Christina Messiou, Emma Nicholson, Alicia Okines, Clare Peckitt, Lisa Pickering, Karin Purshouse, Alison Reid, Caroline Relton, Jennifer Rusby, Scott Shepherd, Ben Shum, Tim Slattery, Naureen Starling, Anthony Swerdlow, Stefan Symeonides, Kate Tatham, Samra Turajlic, Nicholas Turner, Liam Welsh, Katalin Wilkinson, Robert J Wilkinson, Matthew Wheater, Kate Young, and Nadia Yousaf.
The Crick COVID-19 Consortium
Titilayo Abiola, Jim Aitken, Zoe Allen, Rachel Ambler, Karen Ambrose, Emma Ashton, Alida Avola, Samutheswari Balakrishnan, Caitlin Barns-Jenkins, Genevieve Barr, Sam Barrell, Souradeep Basu, Rodrigo Batalha, Rupert Beale, Clare Beesley, Teresa Bertran, Natalie Bevan, Nisha Bhardwaj, Shahnaz Bibi, Ganka Bineva-Todd, Dhruva Biswas, Michael J Blackman, Dominique Bonnet, Carles Bosch, Faye Bowker, Malgorzata Broncel, Claire Brooks, Michael D Buck, Andrew Buckton, Timothy Budd, Alana Burrell, Louise Busby, Claudio Bussi, Simon Butterworth, Matthew Byott, Fiona Byrne, Richard Byrne, Simon Caidan, Veronique Calleja, Enrica Calvani, Joanna Campbell, Johnathan Canton, Ana Cardoso, Nick Carter, Luiz Carvalho, Raffaella Carzaniga, Antonio Casal, Natalie Chandler, Qu Chen, Peter Cherepanov, Laura Churchward, Graham Clark, Bobbi Clayton, Clementina Cobolli Gigli, Zena Collins, Nicola Cook, Cristina Cotobal Martin, Sally Cottrell, Margaret Crawford, Stefania Crotta, Laura Cubitt, Tom Cullup, Annalisa D'Avola, Heledd Davies, Patrick Davis, Dara Davison, Joost De Folter, Vicky Dearing, Solene Debaisieux, Monica Diaz-Romero, Alison Dibbs, Jessica Diring, Paul C Driscoll, Christopher Earl, Amelia Edwards, Chris Ekin, Dimitrios Evangelopoulos, Todd Fallesen, Rupert Faraway, Antony Fearns, Aaron Ferron, Efthymios Fidanis, Patricia Figuiredo-Nunes, Katja Finsterbusch, Dan Fitz, James Fleming, Helen Flynn, Ashley Fowler, Daniel Frampton , Bruno Frederico, Alessandra Gaiba, Anthony Gait, Steve Gamblin, Sonia Gandhi, Julian Gannon, Edmund Garr, Kathleen Gärtner, Acely Garza-Garcia, Liam Gaul, Helen M Golding, Jacki Goldman, Robert Goldstone, Belen Gomez Dominguez, Hui Gong, Ilaria Gori, Paul R Grant, Maria Greco, Mariana Grobler, Anabel Guedan, Silvana Guioli, Maximiliano G Gutierrez, Fiona Hackett, Chris Hadjigeorgiou, Ross Hall, Steinar Halldorsson, Suzanne Harris, Sugera Hashim, Emine Hatipoglu, Lyn Healy, Judith Heaney, Susanne Herbst, Graeme Hewitt, Theresa Higgins, Prisca Hill, Steve Hindmarsh, Rajnika Hirani, Han Ngoc Ho, Maxine Holder, Joshua Hope, Elizabeth Horton, Beth Hoskins, Catherine F Houlihan, Michael Howell, Louise Howitt, Jacqueline Hoyle, Mint R Htun, Michael Hubank, Hector Huerga Encabo, Deborah Hughes, Jane Hughes, Almaz Huseynova, Ming-Shih Hwang, Fairouz Ibrahim, Rachael Instrell, Deborah Jackson, Mariam Jamal-Hanjani, Lucy Jenkins, Ming Jiang, Mark Johnson, Leigh Jones, Neil Justin, Nnennaya Kanu, George Kassiotis, Gavin Kelly, Geoff Kelly, Louise Kiely, Anastacio King Spert Teixeira, Fiona Kinnis, Stuart Kirk, Svend Kjaer, Ellen Knuepfer, Nikita Komarov, Paul Kotzampaltiris, Konstantinos Kousis, Tammy Krylova, Ania Kucharska, Robyn Labrum, Catherine Lambe, Michelle Lappin, Stacey-Ann Lee, Andrew Levett, Lisa Levett, Marcel Levi, Nick Lewis, Hon-Wing Liu, Shuangyan Liu, Sam Loughlin, Wei-Ting Lu, Robert Ludwig, James I MacRae, Akshay Madoo, Sarah Manni, Julie A Marczak, Manuella Marques, Mimmi Martensson, Thomas Martinez, Bishara Marzook, John Matthews, Joachim M Matz, Samuel McCall, Laura E McCoy, Fiona McKay, Edel C McNamara, Sofanit Mebrate, Hilina Mehari, Manuela Melchionda, Carlos M Minutti, Gita Mistry, Miriam Molina-Arcas, Beatriz Montaner, Kylie Montgomery, Catherine Moore, David Moore, Anastasia Moraiti, Raveena Morar, Lucia Moreira-Teixeira, Joyita Mukherjee, Cristina Naceur-Lombardelli, Eleni Nastouli, Aileen Nelson, Jerome Nicod, Luke Nightingale, Stephanie Nofal, Paul Nurse, Savita Nutan, Anne O'Garra, Jean D O'Leary, Olga O'Neill, Nicola O'Reilly, Caroline Oedekoven, Jessica Olsen, Paula Ordonez Suarez, Neil Osborne, Amar Pabari, Aleksandra Pajak, fVenizelos Papayannopoulos, Stavroula M Paraskevopoulou, Namita Patel, Yogen Patel, Oana Paun, Nigel Peat, Laura Peces-Barba Castano, Ana Perez Caballero, Jimena Perez-Lloret, Magali S Perrault, Abigail Perrin, Roy Poh, Enzo Z Poirier, James M Polke, Marc Pollitt, Lucia Prieto-Godino, Alize Proust, Clinda Puvirajasinghe, Val Pye, Christophe Queval, Vijaya Ramachandran, Abhinay Ramaprasad, Peter Ratcliffe, Minoo Razi, Laura Reed, Caetano Reis e Sousa, Kayleigh Richardson, Sophie Ridewood, Karine Rizzoti, Fiona Roberts, Rowenna Roberts, Angela Rodgers, Pablo Romero Clavijo, Annachiara Rosa, Alice Rossi, Chloe Roustan, Andrew Rowan, Erik Sahai, Aaron Sait, Katarzyna Sala, Emilie Sanchez, Theo Sanderson, Pierre Santucci, Fatima Sardar, Adam Sateriale, Jill A Saunders, Chelsea Sawyer, Anja Schlott, Edina Schweighoffer, Sandra Segura-Bayona, Rajvee Shah Punatar, Maryam Shahmanesh, Joe Shaw, Gee Yen Shin, Mariana Silva Dos Santos, Margaux Silvestre, Matthew Singer, Marie Sjothun, Daniel M Snell, Ok-Ryul Song, Christelle Soudy, Moira J Spyer, Louisa Steel, Amy Strange, Adrienne E Sullivan, Charles Swanton, Michele SY Tan, Zoe H Tautz-Davis, Raquel Taveira-Marques, Effie Taylor, Gunes Taylor, Harriet B Taylor, Alison Taylor-Beadling, Fernanda Teixeira Subtil, Berta Terré Torras, Goran Tomic, Patrick Toolan-Kerr, Francesca Torelli, Tea Toteva, Moritz Treeck, Hadija Trojer, Ming-Han C Tsai, James MA Turner, Melanie Turner, Jernej Ule, Rachel Ulferts, Sharon P Vanloo, Selvaraju Veeriah, Raju Veeriah, Mani Venkatesan, Subramanian Venkatesan, Ferdinando Verdirame, Karen Vousden, Andreas Wack, Claire Walder, Jane Walker, Philip A Walker, Yiran Wang, Sophia Ward, Catharina Wenman, Luke Wiliams, Matthew J Williams, Cherry Wong, Wai Keong Wong, Chi Wong, Joshua Wright, Mary Wu, Lauren Wynne, Zheng Xiang, Melvyn Yap, Julian A Zagalak, Davide Zecchin, Rachel Zillwood.