Industry 4.0 makes manufacturers more vulnerable to current challenges and makes it easier to adapt to market changes. This will increase the speed of innovation, make it more customer-oriented and lead to faster design processes. It is essential to focus on monitoring and controlling the production system before complex accidents occur. Moreover, an industrial control system facing information security problems in recent times because of the nature of IoT which affects the evaluation of abnormal predication. To overcome above research gaps, we shift to industrial 4.0 which combine IoT and mechanism learning for industrial monitor and manage. We propose a hybrid machine learning technique for IoT enabled industrial monitoring and control system (IoT-HML). Here, we concentrate both information security issues with accurate monitoring and control system. The first section of proposed IoT-HML system is to introduce the cat induced wheel optimization (IWO) algorithm for cluster formation. The process consists of clustering and cluster head (CH) selection. The source node forward information to destination through CH only which avoids the unwanted data loss and improve the security, because the information travel through trusted path. For route selection process, we utilize the cuckoo search algorithm to compute the optimal best path among multiples. In second section, we illustrate a coach and player learned neural network (CP-LNN) for monitoring the industrial and prevent from accidents by basic control strategies. Finally, the proposed IoT-HML system can evaluate with different set of data’s to prove the effectiveness.